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ORF1 membrane protein UL56 [ Equid alphaherpesvirus 1 (Equine herpesvirus 1) ]

Gene ID: 1487546, updated on 20-Nov-2023

Summary

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Gene symbol
ORF1
Gene description
membrane protein UL56
Locus tag
EhV1gORF1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Equid alphaherpesvirus 1 (strain: Ab4, common: Equine abortion virus, acronym: EAV, acronym: EHV-1, nat-host: Equus caballus)
Lineage
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus
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Genomic context

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Sequence:
NC_001491.2 (1298..1907)

NC_001491.2Genomic Context describing neighboring genes Neighboring gene membrane protein V1 Neighboring gene myristylated tegument protein CIRC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001491.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Equine herpesvirus type 1 pUL56 modulates innate responses of airway epithelial cells. Soboll Hussey G, et al. Virology, 2014 Sep. PMID 25046270
  2. Identification and characterization of equine herpesvirus type 1 pUL56 and its role in virus-induced downregulation of major histocompatibility complex class I. Ma G, et al. J Virol, 2012 Apr. PMID 22278226, Free PMC Article
  3. The deletion of the ORF1 and ORF71 genes reduces virulence of the neuropathogenic EHV-1 strain Ab4 without compromising host immunity in horses. Wimer CL, et al. PLoS One, 2018. PMID 30440016, Free PMC Article
  4. Equine Herpesvirus 1 Multiply Inserted Transmembrane Protein pUL43 Cooperates with pUL56 in Downregulation of Cell Surface Major Histocompatibility Complex Class I. Huang T, et al. J Virol, 2015 Jun. PMID 25833055, Free PMC Article
  5. Major histocompatibility complex class I downregulation induced by equine herpesvirus type 1 pUL56 is through dynamin-dependent endocytosis. Huang T, et al. J Virol, 2014 Nov. PMID 25165105, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In comparison to Ab4, horses infected with Ab4DeltaORF1/71 did not show the initial high fever peak characteristic of EHV-1 infection. Ab4DeltaORF1/71 infection had reduced nasal shedding and decreased intranasal interferon alpha, interleukin 10 and soluble CD14 secretion. Ab4 and Ab4DeltaORF1/71 infection resulted in comparable viremia. Intranasal and serum anti-EHV-1 antibodies to Ab4DeltaORF1/71 developed slightly s...
    Title: The deletion of the ORF1 and ORF71 genes reduces virulence of the neuropathogenic EHV-1 strain Ab4 without compromising host immunity in horses.
  2. This process was dependent on PPxY motifs present in pUL56, suggesting that late domains are required for pUL43- and pUL56-dependent sorting of MHC class I for lysosomal degradation.
    Title: Equine Herpesvirus 1 Multiply Inserted Transmembrane Protein pUL43 Cooperates with pUL56 in Downregulation of Cell Surface Major Histocompatibility Complex Class I.
  3. Equine herpesvirus type 1 pUL56-induced MHC-I endocytosis required dynamin and tyrosine kinase but was independent of clathrin and caveolin-1, the main constituents of the clathrin- and raft/caveola-mediated endocytosis pathways, respectively.
    Title: Major histocompatibility complex class I downregulation induced by equine herpesvirus type 1 pUL56 is through dynamin-dependent endocytosis.
  4. Viral pUL56 modulates innate responses of host airway epithelial cells.
    Title: Equine herpesvirus type 1 pUL56 modulates innate responses of airway epithelial cells.
  5. pUL56 downregulated the major histocompatibility complex class I.
    Title: Identification and characterization of equine herpesvirus type 1 pUL56 and its role in virus-induced downregulation of major histocompatibility complex class I.
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General gene information

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Homology

regulatory

  • Loc: 1902-1907 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
membrane protein UL56
YP_053045.1
  • UL56 family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001491.2 Reference assembly

    Range
    1298..1907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_053045.1 membrane protein UL56 [Equid alphaherpesvirus 1]

    See identical proteins and their annotated locations for YP_053045.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P28978, P84394, P84450, Q6LEL8
    UniProtKB/TrEMBL
    A0A0A7DA54, L8B1Q4
Nucleotide Protein
Heading Accession and Version

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