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UL48 transactivates immediate early genes; involved in gene regulation; involved in virion morphogenesis [ Human alphaherpesvirus 2 ]

Gene ID: 1487335, updated on 18-Aug-2023

Summary

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Gene symbol
UL48
Gene description
transactivates immediate early genes; involved in gene regulation; involved in virion morphogenesis
Locus tag
HHV2p27
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human alphaherpesvirus 2 (strain: HG52, acronym: HHV-2, acronym: HSV-2, nat-host: Homo sapiens)
Lineage
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus
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Genomic context

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Sequence:
NC_001798.2 (104238..105802, complement)

NC_001798.2Genomic Context describing neighboring genes Neighboring gene type 1 membrane protein; contains a signal peptide; binds cell surface heparan sulphate; binds complement C3b to block neutralization; involved in cell attachment Neighboring gene type 2 membrane protein; tegument-associated; possibly involved in membrane fusion Neighboring gene modulates transactivating tegument protein VP16; possibly involved in gene regulation Neighboring gene modulates transactivating tegument protein VP16; RNA-binding protein; possibly involved in gene regulation Neighboring gene type 1 membrane protein; contains a signal peptide; complexed with envelope glycoprotein M; involved in virion morphogenesis; involved in membrane fusion Neighboring gene involved in virion morphogenesis; possibly involved in RNA transport to uninfected cells Neighboring gene involved in nucleotide metabolism

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001798.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cobalt chloride-induced estrogen receptor alpha down-regulation involves hypoxia-inducible factor-1alpha in MCF-7 human breast cancer cells. Cho J, et al. Mol Endocrinol, 2005 May. PMID 15695373
  2. Genomic, phylogenetic, and recombinational characterization of herpes simplex virus 2 strains. Kolb AW, et al. J Virol, 2015 Jun. PMID 25855744, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

regulatory

  • Loc: c104243-104238 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
transactivates immediate early genes; involved in gene regulation; involved in virion morphogenesis
Names
transactivating tegument protein VP16

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001798.2 Reference assembly

    Range
    104238..105802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009137200.1 transactivating tegument protein VP16 [Human alphaherpesvirus 2]

    See identical proteins and their annotated locations for YP_009137200.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P23990, P29793, P68335, P68336
    UniProtKB/TrEMBL
    A0A0E3U2U9, A0A1U9ZDH2, A0A1U9ZEL1, A0A1U9ZFX0, A0A1U9ZJL0, A0A1U9ZKX9, A0A481TAW7, A0A481TH28, A0A481TZK5, A0A7G7P0R9, G9I270, I6TLV8, Q69113
    Conserved Domains (2) summary
    cl03493
    Location:42 → 377
    Alpha_TIF; Alpha trans-inducing protein (Alpha-TIF)
    pfam12149
    Location:465 → 490
    HSV_VP16_C; Herpes simplex virus virion protein 16 C terminal
Nucleotide Protein
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