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CTAG1B cancer/testis antigen 1B [ Homo sapiens (human) ]

Gene ID: 1485, updated on 2-Nov-2024

Summary

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Official Symbol
CTAG1Bprovided by HGNC
Official Full Name
cancer/testis antigen 1Bprovided by HGNC
Primary source
HGNC:HGNC:2491
See related
Ensembl:ENSG00000184033 MIM:300156; AllianceGenome:HGNC:2491
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTAG; ESO1; CT6.1; CTAG1; LAGE-2; LAGE2B; NY-ESO-1
Summary
The protein encoded by this gene is an antigen that is overexpressed in many cancers but that is also expressed in normal testis. This gene is found in a duplicated region of the X-chromosome and therefore has a neighboring gene of identical sequence. [provided by RefSeq, Jan 2012]
Expression
Restricted expression toward testis (RPKM 4.5) See more
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Genomic context

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See CTAG1B in Genome Data Viewer
Location:
Xq28
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (154617609..154619282, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (152854032..152855700, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153845865..153847533, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene activating transcription factor 4 pseudogene 2 Neighboring gene cancer/testis antigen 1A Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:153825347-153825934 Neighboring gene activating transcription factor 4 pseudogene 1 Neighboring gene family with sequence similarity 223 member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression in childhood primary brain tumors of NY-ESO-1, a cancer/testis antigen: an immunohistochemical study. Bodey B, et al. In Vivo, 2008 Jan-Feb. PMID 18396787
  2. Th1/Th2 CD4+ T cell responses against NY-ESO-1 in HLA-DPB1*0401/0402 patients with epithelial ovarian cancer. Qian F, et al. Cancer Immun, 2004 Nov 3. PMID 15521719
  3. NY-ESO-1 is highly expressed in poor-prognosis multiple myeloma and induces spontaneous humoral and cellular immune responses. van Rhee F, et al. Blood, 2005 May 15. PMID 15671442, Free PMC Article
  4. Quantifying and imaging NY-ESO-1/LAGE-1-derived epitopes on tumor cells using high affinity T cell receptors. Purbhoo MA, et al. J Immunol, 2006 Jun 15. PMID 16751374
  5. NY-ESO-1 (CTAG1B) expression in mesenchymal tumors. Endo M, et al. Mod Pathol, 2015 Apr. PMID 25412843

See all (115) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gene of the month: cancer testis antigen gene 1b (NY-ESO-1).
    Title: Gene of the month: cancer testis antigen gene 1b (NY-ESO-1).
  2. The role of PRAME and NY-ESO-1 as potential therapeutic and prognostic biomarkers in triple-negative breast carcinomas.
    Title: The role of PRAME and NY-ESO-1 as potential therapeutic and prognostic biomarkers in triple-negative breast carcinomas.
  3. Clinicopathological assessment of cancer/testis antigens NYESO1 and MAGEA4 in osteosarcoma.
    Title: Clinicopathological assessment of cancer/testis antigens NY‑ESO‑1 and MAGE‑A4 in osteosarcoma.
  4. Expression of CTAG1B clone EPR13780 versus DDIT3 gene rearrangement distinguishes myxoid liposarcoma from its mimics with detection of novel DDIT3 gene copy number variations.
    Title: Expression of CTAG1B clone EPR13780 versus DDIT3 gene rearrangement distinguishes myxoid liposarcoma from its mimics with detection of novel DDIT3 gene copy number variations.
  5. HLA Genotyping in Synovial Sarcoma: Identifying HLA-A*02 and Its Association with Clinical Outcome.
    Title: HLA Genotyping in Synovial Sarcoma: Identifying HLA-A*02 and Its Association with Clinical Outcome.
  6. Evaluation of Production Protocols for the Generation of NY-ESO-1-Specific T Cells.
    Title: Evaluation of Production Protocols for the Generation of NY-ESO-1-Specific T Cells.
  7. MAGE-A4, NY-ESO-1 and SAGE mRNA expression rates and co-expression relationships in solid tumours.
    Title: MAGE-A4, NY-ESO-1 and SAGE mRNA expression rates and co-expression relationships in solid tumours.
  8. The programmed cell death protein-1/programmed cell death ligand 1 expression, CD3+ T cell infiltration, NY-ESO-1 expression, and microsatellite instability phenotype in primary cutaneous melanoma and mucosal melanoma and their clinical significance and prognostic value: a study of 89 consecutive cases.
    Title: The programmed cell death protein-1/programmed cell death ligand 1 expression, CD3+ T cell infiltration, NY-ESO-1 expression, and microsatellite instability phenotype in primary cutaneous melanoma and mucosal melanoma and their clinical significance and prognostic value: a study of 89 consecutive cases.
  9. First-in-Class, First-in-Human Study Evaluating LV305, a Dendritic-Cell Tropic Lentiviral Vector, in Sarcoma and Other Solid Tumors Expressing NY-ESO-1.
    Title: First-in-Class, First-in-Human Study Evaluating LV305, a Dendritic-Cell Tropic Lentiviral Vector, in Sarcoma and Other Solid Tumors Expressing NY-ESO-1.
  10. High NY-ESO-1 expression is associated with non-small cell lung cancer metastasis.
    Title: Expression of New York esophageal squamous cell carcinoma 1 and its association with Foxp3 and indoleamine-2,3-dioxygenase in microenvironment of nonsmall cell lung cancer.
Submit: New GeneRIF Correction See all GeneRIFs (94)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in tRNA threonylcarbamoyladenosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
cancer/testis antigen 1
Names
New York esophageal squamous cell carcinoma 1
autoimmunogenic cancer/testis antigen NY-ESO-1
cancer antigen 3
cancer/testis antigen 6.1
l antigen family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001327.3 → NP_001318.1  cancer/testis antigen 1

    See identical proteins and their annotated locations for NP_001318.1

    Status: REVIEWED

    Source sequence(s)
    AC244107, U87459
    Consensus CDS
    CCDS14758.1
    UniProtKB/Swiss-Prot
    A1L417, B7WNL9, P78358, Q7LBY4, Q9NY13
    Related
    ENSP00000332602.2, ENST00000328435.3
    Conserved Domains (1) summary
    pfam09341
    Location:92 → 162
    Pcc1; Transcription factor Pcc1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    154617609..154619282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    152854032..152855700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P78358.1 GenPept UniProtKB/Swiss-Prot:P78358

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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