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ZNF582 zinc finger protein 582 [ Homo sapiens (human) ]

Gene ID: 147948, updated on 11-Apr-2024

Summary

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Official Symbol
ZNF582provided by HGNC
Official Full Name
zinc finger protein 582provided by HGNC
Primary source
HGNC:HGNC:26421
See related
Ensembl:ENSG00000018869 MIM:615600; AllianceGenome:HGNC:26421
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a zing finger protein and putative transcription factor that is highly methylated in cervical cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in thyroid (RPKM 2.0), testis (RPKM 2.0) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
19q13.43
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (56382751..56393534, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (59476542..59487938, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56894120..56904903, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 5A Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 13801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15118 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:56888366-56889565 Neighboring gene zinc finger protein 542, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:56895030-56896229 Neighboring gene SLC25A36 pseudogene 1 Neighboring gene ZNF582 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15119 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11069 Neighboring gene zinc finger protein 583

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF582 overexpression restrains the progression of clear cell renal cell carcinoma by enhancing the binding of TJP2 and ERK2 and inhibiting ERK2 phosphorylation. Yang W, et al. Cell Death Dis, 2023 Mar 25. PMID 36966163, Free PMC Article
  2. ZNF582 promoter methylation predicts cervical cancer radiosensitivity and ZNF582 protein overexpression reduces radiosensitivity by cell cycle arrest in S phase. Wu N, et al. Epigenetics, 2022 Dec. PMID 35642528, Free PMC Article
  3. ZNF582 hypermethylation promotes metastasis of nasopharyngeal carcinoma by regulating the transcription of adhesion molecules Nectin-3 and NRXN3. Zhao Y, et al. Cancer Commun (Lond), 2020 Dec. PMID 33038291, Free PMC Article
  4. ZNF582 methylation as a potential biomarker to predict cervical intraepithelial neoplasia type III/worse: A meta-analysis of related studies in Chinese population. Li N, et al. Medicine (Baltimore), 2019 Feb. PMID 30732145, Free PMC Article
  5. Concordance analysis of methylation biomarkers detection in self-collected and physician-collected samples in cervical neoplasm. Chang CC, et al. BMC Cancer, 2015 May 19. PMID 25985991, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF582 overexpression restrains the progression of clear cell renal cell carcinoma by enhancing the binding of TJP2 and ERK2 and inhibiting ERK2 phosphorylation.
    Title: ZNF582 overexpression restrains the progression of clear cell renal cell carcinoma by enhancing the binding of TJP2 and ERK2 and inhibiting ERK2 phosphorylation.
  2. ZNF582 promoter methylation predicts cervical cancer radiosensitivity and ZNF582 protein overexpression reduces radiosensitivity by cell cycle arrest in S phase.
    Title: ZNF582 promoter methylation predicts cervical cancer radiosensitivity and ZNF582 protein overexpression reduces radiosensitivity by cell cycle arrest in S phase.
  3. The application value of PAX1 and ZNF582 gene methylation in high grade intraepithelial lesion and cervical cancer.
    Title: The application value of PAX1 and ZNF582 gene methylation in high grade intraepithelial lesion and cervical cancer.
  4. ZNF582 hypermethylation promotes metastasis of nasopharyngeal carcinoma by regulating the transcription of adhesion molecules Nectin-3 and NRXN3.
    Title: ZNF582 hypermethylation promotes metastasis of nasopharyngeal carcinoma by regulating the transcription of adhesion molecules Nectin-3 and NRXN3.
  5. Hypermethylated PAX1 and ZNF582 genes in the tissue sample are associated with aggressive progression of oral squamous cell carcinoma.
    Title: Hypermethylated PAX1 and ZNF582 genes in the tissue sample are associated with aggressive progression of oral squamous cell carcinoma.
  6. The methylation levels ofPAX1, SOX1 and ZNF582 genes were all higher in cancer tissues.
    Title: Aberrant DNA methylation of PAX1, SOX1 and ZNF582 genes as potential biomarkers for esophageal squamous cell carcinoma.
  7. Hypermethylated ZNF582 and PAX1 genes in oral epithelial cells collected by mouth rinse are effective biomarkers for the detection of oral dysplasia and oral cancer.
    Title: Hypermethylated ZNF582 and PAX1 genes in mouth rinse samples as biomarkers for oral dysplasia and oral cancer detection.
  8. ZNF582 methylation has a prospect to be an auxiliary biomarker for cervical cancer (Meta-Analysis)
    Title: ZNF582 methylation as a potential biomarker to predict cervical intraepithelial neoplasia type III/worse: A meta-analysis of related studies in Chinese population.
  9. Hypermethylated ZNF582 and PAX1 genes in the oral scrapings collected from adjacent normal oral mucosal sites rather than cancer sites are associated with aggressive progression and poor prognosis of OSCC
    Title: Hypermethylated ZNF582 and PAX1 genes in oral scrapings collected from cancer-adjacent normal oral mucosal sites are associated with aggressive progression and poor prognosis of oral cancer.
  10. conclude that hypermethylated ZNF582 and PAX1 are effective biomarkers for the detection of oral dysplasia and oral cancer and for the prediction of oral cancer recurrence
    Title: Hypermethylated ZNF582 and PAX1 are effective biomarkers for detection of oral dysplasia and oral cancer.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ30927

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 582

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050571.1 RefSeqGene

    Range
    5052..15835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001320371.4 → NP_001307300.2  zinc finger protein 582

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC006116
    Consensus CDS
    CCDS33121.1
    UniProtKB/Swiss-Prot
    B4DQZ9, B7Z9R3, Q6PJT6, Q96NG8
    Related
    ENSP00000465619.1, ENST00000586929.6
    Conserved Domains (4) summary
    smart00349
    Location:8 → 66
    KRAB; krueppel associated box
    COG5048
    Location:180 → 408
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:341 → 361
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:409 → 434
    zf-H2C2_2; Zinc-finger double domain

  2. NM_144690.3 → NP_653291.1  zinc finger protein 582

    See identical proteins and their annotated locations for NP_653291.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC006116, AK055489, AW080639, BX104812, DA929494
    Consensus CDS
    CCDS33121.1
    UniProtKB/Swiss-Prot
    B4DQZ9, B7Z9R3, Q6PJT6, Q96NG8
    Related
    ENSP00000301310.3, ENST00000301310.8
    Conserved Domains (4) summary
    smart00349
    Location:8 → 66
    KRAB; krueppel associated box
    COG5048
    Location:180 → 408
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:341 → 361
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:409 → 434
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    56382751..56393534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007066621.1 RNA Sequence

  2. XR_430188.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    59476542..59487938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008485106.1 RNA Sequence

  2. XR_008485105.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96NG8.1 GenPept UniProtKB/Swiss-Prot:Q96NG8

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