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VSIG10L V-set and immunoglobulin domain containing 10 like [ Homo sapiens (human) ]

Gene ID: 147645, updated on 5-Mar-2024

Summary

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Official Symbol
VSIG10Lprovided by HGNC
Official Full Name
V-set and immunoglobulin domain containing 10 likeprovided by HGNC
Primary source
HGNC:HGNC:27111
See related
Ensembl:ENSG00000186806 MIM:617740; AllianceGenome:HGNC:27111
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in esophagus (RPKM 25.9), salivary gland (RPKM 8.6) and 4 other tissues See more
Orthologs
mouse all
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Genomic context

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See VSIG10L in Genome Data Viewer
Location:
19q13.41
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51331541..51342139, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54419802..54431866, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51834795..51845393, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985326 Neighboring gene SIGLEC family like 1 pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:51795724-51796402 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:51796403-51797081 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:51797760-51798438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51799797-51800474 Neighboring gene IgLON family member 5 Neighboring gene Sharpr-MPRA regulatory region 10915 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51825217-51825716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51831512-51832434 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10983 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10984 Neighboring gene VSIG10L antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15011 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15012 Neighboring gene electron transfer flavoprotein subunit beta Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:51869249-51870208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10985 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:51871167-51872126 Neighboring gene claudin domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Association Between Germline Mutation in VSIG10L and Familial Barrett Neoplasia. Fecteau RE, et al. JAMA Oncol, 2016 Oct 1. PMID 27467440, Free PMC Article
  2. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
  3. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. Aregger M, et al. Nat Metab, 2020 Jun. PMID 32694731, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
V-set and immunoglobulin domain-containing protein 10-like
Names
VSIG10-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163922.3 → NP_001157394.1  V-set and immunoglobulin domain-containing protein 10-like precursor

    See identical proteins and their annotated locations for NP_001157394.1

    Status: VALIDATED

    Source sequence(s)
    AC008750, AC063977
    Consensus CDS
    CCDS54300.1
    UniProtKB/Swiss-Prot
    Q86VR7
    Related
    ENSP00000335623.3, ENST00000335624.5
    Conserved Domains (5) summary
    cd00096
    Location:320 → 389
    Ig; Immunoglobulin domain
    smart00408
    Location:421 → 476
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:418 → 490
    IG_like; Immunoglobulin like
    pfam07679
    Location:302 → 395
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:198 → 298
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    51331541..51342139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    54419802..54431866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319847.1 → XP_054175822.1  V-set and immunoglobulin domain-containing protein 10-like isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86VR7.2 GenPept UniProtKB/Swiss-Prot:Q86VR7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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