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Gpm6b glycoprotein m6b [ Mus musculus (house mouse) ]

Gene ID: 14758, updated on 2-Nov-2024

Summary

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Official Symbol
Gpm6bprovided by MGI
Official Full Name
glycoprotein m6bprovided by MGI
Primary source
MGI:MGI:107672
See related
Ensembl:ENSMUSG00000031342 AllianceGenome:MGI:107672
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M6B; Gpm6
Summary
Predicted to be a structural constituent of myelin sheath. Involved in negative regulation of protein localization to cell surface and negative regulation of serotonin uptake. Located in membrane raft and plasma membrane. Is expressed in central nervous system; genitourinary system; and retina. Orthologous to human GPM6B (glycoprotein M6B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 105.8), cortex adult (RPKM 101.8) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Gpm6b in Genome Data Viewer
Location:
X F5; X 76.86 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (165021911..165172028)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (166238943..166389033)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene glucosaminyl (N-acetyl) transferase 1, core 2 pseudogene Neighboring gene gem nuclear organelle associated protein 8 Neighboring gene STARR-seq mESC enhancer starr_48252 Neighboring gene OFD1, centriole and centriolar satellite protein Neighboring gene STARR-positive B cell enhancer ABC_E11806 Neighboring gene trafficking protein particle complex 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:162917789-162917898 Neighboring gene RAB9, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning and transfection studies of M6b-2, a novel splice variant of a member of the PLP-DM20/M6 gene family. Vouyiouklis DA, et al. J Neurosci Res, 1998 Jun 15. PMID 9669312
  2. A mutant allele of glycoprotein M6-B (Gpm6b) facilitates behavioral flexibility but increases delay discounting. Sanchez-Roige S, et al. Genes Brain Behav, 2022 Apr. PMID 35243767, Free PMC Article
  3. Gpm6b deficiency impairs sensorimotor gating and modulates the behavioral response to a 5-HT2A/C receptor agonist. Dere E, et al. Behav Brain Res, 2015 Jan 15. PMID 24768641
  4. A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system. Werner HB, et al. Glia, 2013 Apr. PMID 23322581
  5. Multiple splice isoforms of proteolipid M6B in neurons and oligodendrocytes. Werner H, et al. Mol Cell Neurosci, 2001 Dec. PMID 11749036

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A mutant allele of glycoprotein M6-B (Gpm6b) facilitates behavioral flexibility but increases delay discounting.
    Title: A mutant allele of glycoprotein M6-B (Gpm6b) facilitates behavioral flexibility but increases delay discounting.
  2. FTO regulates ocular angiogenesis via m(6)A-YTHDF2-dependent mechanism.
    Title: FTO regulates ocular angiogenesis via m(6)A-YTHDF2-dependent mechanism.
  3. Findings demonstrate that GPM6B plays a crucial role in SMC differentiation and regulates SMC differentiation through the activation of TGF-beta-Smad2/3 signaling via direct interactions with TbetaRI.
    Title: Glycoprotein M6B Interacts with TβRI to Activate TGF-β-Smad2/3 Signaling and Promote Smooth Muscle Cell Differentiation.
  4. Study identified glycoprotein M6B as a Schwann cell microvilli component of peripheral nodes of Ranvier. Study detected Na(+) channel clusters at heminodes without any associated M6B, indicating that it is not required for initial channel clustering; showed that absence of M6B results in progressive appearance of nodal protrusions of the nodal axolemma, that are often accompanied by the presence of enlarged mitochondria.
    Title: Glial M6B stabilizes the axonal membrane at peripheral nodes of Ranvier.
  5. The results of this study proposed that M6b proteins are required for proper extension and guidance of callosal axons that follow one of the most complex trajectories in the mammalian nervous system.
    Title: Transcallosal Projections Require Glycoprotein M6-Dependent Neurite Growth and Guidance.
  6. M6B is not efficiently sorted into mature myelin, in which it is 200-fold less abundant than proteolipid protein (PLP).
    Title: A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system myelination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extracellular matrix assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in extracellular matrix assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of protein localization to cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of serotonin uptake IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of serotonin uptake IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ossification IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
neuronal membrane glycoprotein M6-b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177955.2 → NP_001171426.1  neuronal membrane glycoprotein M6-b isoform 1

    See identical proteins and their annotated locations for NP_001171426.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL671905
    Consensus CDS
    CCDS53245.1
    UniProtKB/Swiss-Prot
    A2AEG4, P35803, Q8R3J6, Q99L14, Q9D4F5, Q9JHG9, Q9JHI1, Q9JHK2, Q9JI62, Q9JI63, Q9JI64, Q9JI65
    UniProtKB/TrEMBL
    A2AEG6
    Related
    ENSMUSP00000107848.3, ENSMUST00000112229.9
    Conserved Domains (1) summary
    pfam01275
    Location:62 → 298
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

  2. NM_001177956.2 → NP_001171427.1  neuronal membrane glycoprotein M6-b isoform 2

    See identical proteins and their annotated locations for NP_001171427.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional segment in the 3' region, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AL671905
    Consensus CDS
    CCDS53244.1
    UniProtKB/Swiss-Prot
    A2AEG4, P35803, Q8R3J6, Q99L14, Q9D4F5, Q9JHG9, Q9JHI1, Q9JHK2, Q9JI62, Q9JI63, Q9JI64, Q9JI65
    UniProtKB/TrEMBL
    A2AEG3
    Related
    ENSMUSP00000107842.2, ENSMUST00000112223.8
    Conserved Domains (1) summary
    pfam01275
    Location:62 → 298
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

  3. NM_001177957.2 → NP_001171428.1  neuronal membrane glycoprotein M6-b isoform 2

    See identical proteins and their annotated locations for NP_001171428.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an additional exon in the 3' region, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AL671905
    Consensus CDS
    CCDS53244.1
    UniProtKB/Swiss-Prot
    A2AEG4, P35803, Q8R3J6, Q99L14, Q9D4F5, Q9JHG9, Q9JHI1, Q9JHK2, Q9JI62, Q9JI63, Q9JI64, Q9JI65
    UniProtKB/TrEMBL
    A2AEG3
    Related
    ENSMUSP00000107846.3, ENSMUST00000112227.9
    Conserved Domains (1) summary
    pfam01275
    Location:62 → 298
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

  4. NM_001177958.2 → NP_001171429.1  neuronal membrane glycoprotein M6-b isoform 3

    See identical proteins and their annotated locations for NP_001171429.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AL671905
    Consensus CDS
    CCDS53247.1
    UniProtKB/Swiss-Prot
    A2AEG4, P35803, Q8R3J6, Q99L14, Q9D4F5, Q9JHG9, Q9JHI1, Q9JHK2, Q9JI62, Q9JI63, Q9JI64, Q9JI65
    UniProtKB/TrEMBL
    Q3US81
    Related
    ENSMUSP00000107847.2, ENSMUST00000112228.8
    Conserved Domains (1) summary
    pfam01275
    Location:22 → 258
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

  5. NM_001177959.2 → NP_001171430.1  neuronal membrane glycoprotein M6-b isoform 5

    See identical proteins and their annotated locations for NP_001171430.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an in-frame exon in the 5' region and has an additional segment in the 3' region,, as compared to variant 1. The resulting isoform (5) lacks an internal segment and has a shorter and different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AL671905
    Consensus CDS
    CCDS53246.1
    UniProtKB/Swiss-Prot
    P35803
    Related
    ENSMUSP00000107843.2, ENSMUST00000112224.8
    Conserved Domains (1) summary
    pfam01275
    Location:22 → 258
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

  6. NM_001177960.2 → NP_001171431.1  neuronal membrane glycoprotein M6-b isoform 5

    See identical proteins and their annotated locations for NP_001171431.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an in-frame exon in the 5' region and has an additional exon in the 3' region,, as compared to variant 1. The resulting isoform (5) lacks an internal segment and has a shorter and different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AL671905
    Consensus CDS
    CCDS53246.1
    UniProtKB/Swiss-Prot
    P35803
    Related
    ENSMUSP00000107845.3, ENSMUST00000112226.3
    Conserved Domains (1) summary
    pfam01275
    Location:22 → 258
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

  7. NM_001177961.2 → NP_001171432.1  neuronal membrane glycoprotein M6-b isoform 6

    See identical proteins and their annotated locations for NP_001171432.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has an alternate 5' sequence and an additional segment in the 3' region,, as compared to variant 1. The resulting isoform (6) is shorter and has different N- and C-termini, as compared to isoform 1.
    Source sequence(s)
    AL671905, AL713990
    Consensus CDS
    CCDS53243.1
    UniProtKB/TrEMBL
    Q3V0Z9
    Related
    ENSMUSP00000107854.2, ENSMUST00000112235.8
    Conserved Domains (1) summary
    pfam01275
    Location:3 → 239
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

  8. NM_001177962.2 → NP_001171433.1  neuronal membrane glycoprotein M6-b isoform 6

    See identical proteins and their annotated locations for NP_001171433.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) has an alternate 5' sequence and an additional exon in the 3' region,, as compared to variant 1. The resulting isoform (6) is shorter and has different N- and C-termini, as compared to isoform 1.
    Source sequence(s)
    AL671905, AL713990
    Consensus CDS
    CCDS53243.1
    UniProtKB/TrEMBL
    Q3V0Z9
    Related
    ENSMUSP00000107852.2, ENSMUST00000112233.8
    Conserved Domains (1) summary
    pfam01275
    Location:3 → 239
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

  9. NM_001425662.1 → NP_001412591.1  neuronal membrane glycoprotein M6-b isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL671905, AL713990

  10. NM_001425663.1 → NP_001412592.1  neuronal membrane glycoprotein M6-b isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL671905

  11. NM_001425664.1 → NP_001412593.1  neuronal membrane glycoprotein M6-b isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL671905, AL713990

  12. NM_001425665.1 → NP_001412594.1  neuronal membrane glycoprotein M6-b isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL671905

  13. NM_001425666.1 → NP_001412595.1  neuronal membrane glycoprotein M6-b isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL671905, AL713990

  14. NM_023122.4 → NP_075611.1  neuronal membrane glycoprotein M6-b isoform 4

    See identical proteins and their annotated locations for NP_075611.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (4) is shorter and has a different N-terminus, as compared to isoform 1.
    Source sequence(s)
    AL671905, AL713990
    Consensus CDS
    CCDS30526.1
    UniProtKB/Swiss-Prot
    A2AEG4, P35803, Q8R3J6, Q99L14, Q9D4F5, Q9JHG9, Q9JHI1, Q9JHK2, Q9JI62, Q9JI63, Q9JI64, Q9JI65
    Related
    ENSMUSP00000060442.8, ENSMUST00000060210.14
    Conserved Domains (1) summary
    pfam01275
    Location:3 → 239
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    165021911..165172028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161822.1 → XP_036017715.1  neuronal membrane glycoprotein M6-b isoform X3

    UniProtKB/Swiss-Prot
    A2AEG4, P35803, Q8R3J6, Q99L14, Q9D4F5, Q9JHG9, Q9JHI1, Q9JHK2, Q9JI62, Q9JI63, Q9JI64, Q9JI65
    Conserved Domains (1) summary
    pfam01275
    Location:43 → 279
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

  2. XM_011247784.3 → XP_011246086.1  neuronal membrane glycoprotein M6-b isoform X1

    UniProtKB/Swiss-Prot
    A2AEG4, P35803, Q8R3J6, Q99L14, Q9D4F5, Q9JHG9, Q9JHI1, Q9JHK2, Q9JI62, Q9JI63, Q9JI64, Q9JI65
    Conserved Domains (1) summary
    pfam01275
    Location:61 → 297
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35803.2 GenPept UniProtKB/Swiss-Prot:P35803

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