U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

rad50 DNA double-strand break repair ATPase Rad50 [ Pyrococcus furiosus DSM 3638 ]

Gene ID: 1469036, updated on 24-Oct-2024

Summary

Go to the top of the page Help
Gene symbol
rad50
Gene description
DNA double-strand break repair ATPase Rad50
Locus tag
PF_RS05855
Gene type
protein coding
Organism
Pyrococcus furiosus DSM 3638 (strain: DSM 3638, type-material: type strain of Pyrococcus furiosus)
Lineage
Archaea; Methanobacteriati; Methanobacteriota; Thermococci; Thermococcales; Thermococcaceae; Pyrococcus
Old locus tag
PF1167
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_003413.1 (1114820..1117468)

NC_003413.1Genomic Context describing neighboring genes Neighboring gene cation:proton antiporter Neighboring gene DNA double-strand break repair helicase HerA Neighboring gene DNA double-strand break repair protein Mre11 Neighboring gene DNA double-strand break repair nuclease NurA Neighboring gene DUF2103 domain-containing protein Neighboring gene hypothetical protein Neighboring gene nucleotidyltransferase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003413.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A rod conformation of the Pyrococcus furiosus Rad50 coiled coil. Soh YM, et al. Proteins, 2021 Feb. PMID 32875643
  2. A dynamic allosteric pathway underlies Rad50 ABC ATPase function in DNA repair. Boswell ZK, et al. Sci Rep, 2018 Jan 26. PMID 29374232, Free PMC Article
  3. The P. furiosus mre11/rad50 complex promotes 5' strand resection at a DNA double-strand break. Hopkins BB, et al. Cell, 2008 Oct 17. PMID 18957200, Free PMC Article
  4. Mre11 and Rad50 from Pyrococcus furiosus: cloning and biochemical characterization reveal an evolutionarily conserved multiprotein machine. Hopfner KP, et al. J Bacteriol, 2000 Nov. PMID 11029422, Free PMC Article
  5. Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase. Hopfner KP, et al. Cell, 2001 May 18. PMID 11371344

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A rod conformation of the Pyrococcus furiosus Rad50 coiled coil.
    Title: A rod conformation of the Pyrococcus furiosus Rad50 coiled coil.
  2. Together, these data suggest an equilibrium between a ground state and an "active" dimerization competent state of Rad50 that has locally altered structure and dynamics and is poised for ATP-induced dimerization and eventual ATP hydrolysis.
    Title: A dynamic allosteric pathway underlies Rad50 ABC ATPase function in DNA repair.
  3. Study shows that at limiting levels of HerA and NurA, PfMre11/Rad50 is required for 5' end resection and that this process is dependent upon the enzymatic activities of HerA, NurA, and Rad50 but not Mre11.
    Title: The P. furiosus mre11/rad50 complex promotes 5' strand resection at a DNA double-strand break.
Submit: New GeneRIF Correction

General protein information

Go to the top of the page Help
Preferred Names
DNA double-strand break repair ATPase Rad50

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003413.1 Reference assembly

    Range
    1114820..1117468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_011012307.1 DNA double-strand break repair ATPase Rad50 [Pyrococcus furiosus]

    See identical proteins and their annotated locations for WP_011012307.1

    UniProtKB/Swiss-Prot
    P58301
    UniProtKB/TrEMBL
    A0A5C0XVK1, I6V1L4
    Conserved Domains (1) summary
    PRK03918
    Location:1 → 882
    PRK03918; DNA double-strand break repair ATPase Rad50
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58301.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.