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SLC22A31 solute carrier family 22 member 31 [ Homo sapiens (human) ]

Gene ID: 146429, updated on 5-Mar-2024

Summary

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Official Symbol
SLC22A31provided by HGNC
Official Full Name
solute carrier family 22 member 31provided by HGNC
Primary source
HGNC:HGNC:27091
See related
Ensembl:ENSG00000259803 AllianceGenome:HGNC:27091
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in ion transport and transmembrane transport. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
Expression
Biased expression in lung (RPKM 12.0), pancreas (RPKM 1.5) and 2 other tissues See more
Orthologs
all
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Genomic context

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See SLC22A31 in Genome Data Viewer
Location:
16q24.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (89195761..89201678, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (95275967..95281802, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (89262169..89268086, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89233179-89234027 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89234028-89234875 Neighboring gene long intergenic non-protein coding RNA 2138 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7893 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89241373-89241872 Neighboring gene cadherin 15 Neighboring gene Sharpr-MPRA regulatory region 11767 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11396 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7894 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89260181-89260846 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89265225-89265848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89267097-89267719 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7895 Neighboring gene Sharpr-MPRA regulatory region 4154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11397 Neighboring gene ZNF778 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89284467-89284997 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89284998-89285527 Neighboring gene zinc finger protein 778 Neighboring gene Sharpr-MPRA regulatory region 2584

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Whole-genome sequencing reveals host factors underlying critical COVID-19. Kousathanas A, et al. Nature, 2022 Jul. PMID 35255492, Free PMC Article
  2. The sequence and analysis of duplication-rich human chromosome 16. Martin J, et al. Nature, 2004 Dec 23. PMID 15616553

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative solute carrier family 22 member 31
Names
putative solute carrier family 22 member ENSG00000182157

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366322.1 → NP_001353251.1  putative solute carrier family 22 member 31 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC009113

  2. NM_001384763.1 → NP_001371692.1  putative solute carrier family 22 member 31 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC009113
    Consensus CDS
    CCDS92209.1
    Related
    ENSP00000508250.1, ENST00000682282.1
    Conserved Domains (1) summary
    cl28910
    Location:9 → 383
    MFS; Major Facilitator Superfamily

  3. NM_001384764.1 → NP_001371693.1  putative solute carrier family 22 member 31 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC009113
    Conserved Domains (1) summary
    cl28910
    Location:1 → 316
    MFS; Major Facilitator Superfamily

  4. NM_001384765.1 → NP_001371694.1  putative solute carrier family 22 member 31 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC009113
    Conserved Domains (2) summary
    TIGR00898
    Location:4 → 115
    2A0119; cation transport protein
    cl28910
    Location:1 → 187
    MFS; Major Facilitator Superfamily

  5. NM_001384766.1 → NP_001371695.1  putative solute carrier family 22 member 31 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 6-8, encodes isoform e.
    Source sequence(s)
    AC009113
    Consensus CDS
    CCDS73927.1
    UniProtKB/TrEMBL
    A0A087WY01
    Related
    ENSP00000474621.2, ENST00000562855.7
    Conserved Domains (1) summary
    cl28910
    Location:1 → 275
    MFS; Major Facilitator Superfamily

  6. NM_001384767.1 → NP_001371696.1  putative solute carrier family 22 member 31 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 5, 7, and 8, encodes isoform e.
    Source sequence(s)
    AC009113
    Consensus CDS
    CCDS73927.1
    UniProtKB/TrEMBL
    A0A087WY01
    Conserved Domains (1) summary
    cl28910
    Location:1 → 275
    MFS; Major Facilitator Superfamily

  7. NM_001384768.1 → NP_001371697.1  putative solute carrier family 22 member 31 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 5, 6, and 8, encodes isoform e.
    Source sequence(s)
    AC009113
    Consensus CDS
    CCDS73927.1
    UniProtKB/TrEMBL
    A0A087WY01
    Conserved Domains (1) summary
    cl28910
    Location:1 → 275
    MFS; Major Facilitator Superfamily

  8. NM_001384769.1 → NP_001371698.1  putative solute carrier family 22 member 31 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 5-7, encodes isoform e.
    Source sequence(s)
    AC009113
    Consensus CDS
    CCDS73927.1
    UniProtKB/TrEMBL
    A0A087WY01
    Related
    ENSP00000481421.1, ENST00000614943.4
    Conserved Domains (1) summary
    cl28910
    Location:1 → 275
    MFS; Major Facilitator Superfamily

  9. NM_001384770.1 → NP_001371699.1  putative solute carrier family 22 member 31 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC009113
    Conserved Domains (1) summary
    cl28910
    Location:1 → 239
    MFS; Major Facilitator Superfamily

  10. NM_001384771.1 → NP_001371700.1  putative solute carrier family 22 member 31 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC009113
    Conserved Domains (1) summary
    cl28910
    Location:1 → 237
    MFS; Major Facilitator Superfamily

  11. NM_001384772.1 → NP_001371701.1  putative solute carrier family 22 member 31 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 12 and 13, encodes isoform h.
    Source sequence(s)
    AC009113
    Conserved Domains (1) summary
    cl28910
    Location:25 → 181
    MFS; Major Facilitator Superfamily

  12. NM_001384773.1 → NP_001371702.1  putative solute carrier family 22 member 31 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 11 and 13, encodes isoform h.
    Source sequence(s)
    AC009113
    Conserved Domains (1) summary
    cl28910
    Location:25 → 181
    MFS; Major Facilitator Superfamily

  13. NM_001384775.1 → NP_001371704.1  putative solute carrier family 22 member 31 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 11 and 12, encodes isoform h.
    Source sequence(s)
    AC009113
    Conserved Domains (1) summary
    cl28910
    Location:25 → 181
    MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    89195761..89201678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433647.1 → XP_047289603.1  putative solute carrier family 22 member 31 isoform X2

  2. XM_017022962.2 → XP_016878451.1  putative solute carrier family 22 member 31 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    95275967..95281802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001242757.1: Suppressed sequence

    Description
    NM_001242757.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NKX4.4 GenPept UniProtKB/Swiss-Prot:A6NKX4

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