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Gykl1 glycerol kinase-like 1 [ Mus musculus (house mouse) ]

Gene ID: 14625, updated on 28-Oct-2024

Summary

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Official Symbol
Gykl1provided by MGI
Official Full Name
glycerol kinase-like 1provided by MGI
Primary source
MGI:MGI:891990
See related
Ensembl:ENSMUSG00000053624 AllianceGenome:MGI:891990
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gk-rs1
Summary
Predicted to enable glycerol kinase activity. Predicted to be involved in glycerol metabolic process; glycerol-3-phosphate biosynthetic process; and triglyceride metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in glycerol kinase deficiency. Orthologous to human GK (glycerol kinase). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
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Genomic context

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See Gykl1 in Genome Data Viewer
Location:
18 D1; 18 28.25 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (52826751..52828665)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (52693679..52695593)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 474 Neighboring gene RIKEN cDNA 1700034E13 gene Neighboring gene predicted gene, 41725 Neighboring gene synuclein, alpha interacting protein (synphilin) Neighboring gene predicted gene, 50457

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glycerol kinase 2 is essential for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during mouse spermatogenesis. Shimada K, et al. J Reprod Dev, 2019 Apr 12. PMID 30662012, Free PMC Article
  2. Glycerol kinase-like proteins cooperate with Pld6 in regulating sperm mitochondrial sheath formation and male fertility. Chen Y, et al. Cell Discov, 2017. PMID 28852571, Free PMC Article
  3. Sequence analysis, identification of evolutionary conserved motifs and expression analysis of murine tcof1 provide further evidence for a potential function for the gene and its human homologue, TCOF1. Dixon J, et al. Hum Mol Genet, 1997 May. PMID 9158147
  4. Mouse TCOF1 is expressed widely, has motifs conserved in nucleolar phosphoproteins, and maps to chromosome 18. Paznekas WA, et al. Biochem Biophys Res Commun, 1997 Sep 8. PMID 9299440
  5. Retrotransposition of glycerol kinase-related genes from the X chromosome to autosomes: functional and evolutionary aspects. Pan Y, et al. Genomics, 1999 Aug 1. PMID 10444329

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC141317

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerol kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in glycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycerol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol-3-phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in triglyceride metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glycerol kinase-like 1
Names
glucokinase activity, related sequence 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010293.3 → NP_034423.2  glycerol kinase-like 1

    See identical proteins and their annotated locations for NP_034423.2

    Status: VALIDATED

    Source sequence(s)
    AC121943, AK076631
    Consensus CDS
    CCDS29250.1
    UniProtKB/TrEMBL
    Q0VDQ2, Q8C635
    Related
    ENSMUSP00000067598.4, ENSMUST00000066193.5
    Conserved Domains (2) summary
    cd07792
    Location:11 → 513
    FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
    TIGR01311
    Location:11 → 513
    glycerol_kin; glycerol kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    52826751..52828665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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