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CMTM4 CKLF like MARVEL transmembrane domain containing 4 [ Homo sapiens (human) ]

Gene ID: 146223, updated on 11-Apr-2024

Summary

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Official Symbol
CMTM4provided by HGNC
Official Full Name
CKLF like MARVEL transmembrane domain containing 4provided by HGNC
Primary source
HGNC:HGNC:19175
See related
Ensembl:ENSG00000183723 MIM:607887; AllianceGenome:HGNC:19175
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKLFSF4
Summary
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Broad expression in thyroid (RPKM 48.0), kidney (RPKM 20.0) and 16 other tissues See more
Orthologs
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Genomic context

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See CMTM4 in Genome Data Viewer
Location:
16q21-q22.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (66598178..66696743, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (72359915..72491037, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (66648653..66730646, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CKLF-CMTM1 readthrough Neighboring gene CKLF like MARVEL transmembrane domain containing 1 Neighboring gene CKLF like MARVEL transmembrane domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7561 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7562 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66642903-66643714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:66653785-66654286 Neighboring gene CKLF like MARVEL transmembrane domain containing 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:66677635-66677813 Neighboring gene Sharpr-MPRA regulatory region 8452 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:66708833-66709036 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:66710611-66711112 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66725551-66726230 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66726231-66726910 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66726911-66727590 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:66729849-66730688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7566 Neighboring gene dynein cytoplasmic 1 light intermediate chain 2 Neighboring gene MPRA-validated peak2616 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:66785153-66785868 Neighboring gene DYNC1LI2 divergent transcript Neighboring gene telomere repeat binding bouquet formation protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Prognostic significance and immune characteristics of CMTM4 in hepatocellular carcinoma. Tan S, et al. BMC Cancer, 2022 Aug 19. PMID 35986302, Free PMC Article
  2. Inhibition of CMTM4 Sensitizes Cholangiocarcinoma and Hepatocellular Carcinoma to T Cell-Mediated Antitumor Immunity Through PD-L1. Chui NN, et al. Hepatol Commun, 2022 Jan. PMID 34558800, Free PMC Article
  3. CMTM4 inhibits cell proliferation and migration via AKT, ERK1/2, and STAT3 pathway in colorectal cancer. Xue H, et al. Acta Biochim Biophys Sin (Shanghai), 2019 Sep 6. PMID 31435638
  4. CMTM4 is frequently downregulated and functions as a tumour suppressor in clear cell renal cell carcinoma. Li T, et al. J Exp Clin Cancer Res, 2015 Oct 16. PMID 26474560, Free PMC Article
  5. Identification and characterization of CMTM4, a novel gene with inhibitory effects on HeLa cell growth through Inducing G2/M phase accumulation. Plate M, et al. Mol Cells, 2010 Apr. PMID 20213316

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prognostic significance of RKIP, TGM2, and CMTM4 expression in oral squamous cell carcinoma.
    Title: Prognostic significance of RKIP, TGM2, and CMTM4 expression in oral squamous cell carcinoma.
  2. CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology.
    Title: CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology.
  3. Analysis of CMTM6 and CMTM4 expression as potential regulators of the PD-L1 protein and its association with prognosis in glioma cancer.
    Title: Analysis of CMTM6 and CMTM4 expression as potential regulators of the PD-L1 protein and its association with prognosis in glioma cancer.
  4. Prognostic significance and immune characteristics of CMTM4 in hepatocellular carcinoma.
    Title: Prognostic significance and immune characteristics of CMTM4 in hepatocellular carcinoma.
  5. CMTM6 and CMTM4 as two novel regulators of PD-L1 modulate the tumor microenvironment.
    Title: CMTM6 and CMTM4 as two novel regulators of PD-L1 modulate the tumor microenvironment.
  6. Exosomal miR-224-5p from Colorectal Cancer Cells Promotes Malignant Transformation of Human Normal Colon Epithelial Cells by Promoting Cell Proliferation through Downregulation of CMTM4.
    Title: Exosomal miR-224-5p from Colorectal Cancer Cells Promotes Malignant Transformation of Human Normal Colon Epithelial Cells by Promoting Cell Proliferation through Downregulation of CMTM4.
  7. CircCYP24A1 hampered malignant phenotype of renal cancer carcinoma through modulating CMTM-4 expression via sponging miR-421.
    Title: CircCYP24A1 hampered malignant phenotype of renal cancer carcinoma through modulating CMTM-4 expression via sponging miR-421.
  8. Inhibition of CMTM4 Sensitizes Cholangiocarcinoma and Hepatocellular Carcinoma to T Cell-Mediated Antitumor Immunity Through PD-L1.
    Title: Inhibition of CMTM4 Sensitizes Cholangiocarcinoma and Hepatocellular Carcinoma to T Cell-Mediated Antitumor Immunity Through PD-L1.
  9. Pancreatic stellate cells derived exosomal miR-5703 promotes pancreatic cancer by downregulating CMTM4 and activating PI3K/Akt pathway.
    Title: Pancreatic stellate cells derived exosomal miR-5703 promotes pancreatic cancer by downregulating CMTM4 and activating PI3K/Akt pathway.
  10. CMTM4 plays an important role in the turnover of membrane-bound VE-cadherin at AJs, mediating endothelial barrier function and controlling vascular sprouting.
    Title: CMTM4 regulates angiogenesis by promoting cell surface recycling of VE-cadherin to endothelial adherens junctions.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CKLF-like MARVEL transmembrane domain-containing protein 4
Names
chemokine-like factor super family 4
chemokine-like factor superfamily member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178818.3 → NP_848933.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_848933.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC018557, AF521889
    Consensus CDS
    CCDS10817.1
    UniProtKB/Swiss-Prot
    Q52M40, Q8IZR4, Q8IZR5, Q8IZV1
    Related
    ENSP00000333833.4, ENST00000330687.8
    Conserved Domains (1) summary
    pfam01284
    Location:49 → 170
    MARVEL; Membrane-associating domain

  2. NM_181521.3 → NP_852662.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform 2

    See identical proteins and their annotated locations for NP_852662.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an additional segment in the 3' coding region that leads to an upstream stop codon, compared to variant 1. The encoded protein (isoform 2) has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AC018557, AF479814, AW207043
    Consensus CDS
    CCDS42170.1
    UniProtKB/Swiss-Prot
    Q8IZR5
    Related
    ENSP00000377666.2, ENST00000394106.7
    Conserved Domains (1) summary
    pfam01284
    Location:49 → 170
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    66598178..66696743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022954.2 → XP_016878443.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X1

  2. XM_011522882.2 → XP_011521184.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X2

    See identical proteins and their annotated locations for XP_011521184.1

    UniProtKB/Swiss-Prot
    Q8IZR5
    Related
    ENSP00000456380.1, ENST00000563952.1
    Conserved Domains (1) summary
    pfam01284
    Location:34 → 141
    MARVEL; Membrane-associating domain

RNA

  1. XR_933209.3 RNA Sequence

  2. XR_933210.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    72359915..72491037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379651.1 → XP_054235626.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X3

  2. XM_054379652.1 → XP_054235627.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X4

  3. XM_054379653.1 → XP_054235628.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X5

  4. XM_054379654.1 → XP_054235629.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X6

  5. XM_054379655.1 → XP_054235630.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X1

  6. XM_054379656.1 → XP_054235631.1  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X2

RNA

  1. XR_008489057.1 RNA Sequence

  2. XR_008489058.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IZR5.1 GenPept UniProtKB/Swiss-Prot:Q8IZR5

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