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Cblif cobalamin binding intrinsic factor [ Mus musculus (house mouse) ]

Gene ID: 14603, updated on 2-Nov-2024

Summary

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Official Symbol
Cblifprovided by MGI
Official Full Name
cobalamin binding intrinsic factorprovided by MGI
Primary source
MGI:MGI:1202394
See related
Ensembl:ENSMUSG00000024682 AllianceGenome:MGI:1202394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IF; Gif; INF
Summary
Enables cargo receptor ligand activity and cobalamin binding activity. Involved in cobalamin transport. Is active in extracellular space. Is expressed in gut and lung. Human ortholog(s) of this gene implicated in congenital intrinsic factor deficiency and pernicious anemia. Orthologous to human CBLIF (cobalamin binding intrinsic factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward stomach adult (RPKM 445.2) See more
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Genomic context

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See Cblif in Genome Data Viewer
Location:
19 A; 19 8.51 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (11724907..11740811)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (11747543..11763447)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene oocyte secreted protein 3 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 3 pseudogene Neighboring gene predicted gene, 52408 Neighboring gene predicted gene, 46655 Neighboring gene STARR-positive B cell enhancer ABC_E8740 Neighboring gene mitochondrial ribosomal protein L16 Neighboring gene syntaxin 3 Neighboring gene STARR-seq mESC enhancer starr_45577 Neighboring gene predicted gene, 41810

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Vitamin B₁₂-dependent taurine synthesis regulates growth and bone mass. Roman-Garcia P, et al. J Clin Invest, 2014 Jul. PMID 24911144, Free PMC Article
  2. Infection Susceptibility in Gastric Intrinsic Factor (Vitamin B12)-Defective Mice Is Subject to Maternal Influences. Mottram L, et al. mBio, 2016 Jun 21. PMID 27329747, Free PMC Article
  3. Maternal vitamin B(12) in mice positively regulates bone, but not muscle mass and strength in post-weaning and mature offspring. Singh P, et al. Am J Physiol Regul Integr Comp Physiol, 2021 Jun 1. PMID 33759575, Free PMC Article
  4. Oncogenic Fatty Acid Metabolism Rewires Energy Supply Chain in Gastric Carcinogenesis. Won Y, et al. Gastroenterology, 2024 May. PMID 38272100, Free PMC Article
  5. Use of transgenic mice to study regulation of gene expression in the parietal cell lineage of gastric units. Lorenz RG, et al. J Biol Chem, 1993 Dec 15. PMID 8253786

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5)  1 citation
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC144768

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cargo receptor ligand activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cargo receptor ligand activity ISO
Inferred from Sequence Orthology
more info
  
enables cobalamin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cobalamin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cobalamin binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular carrier activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cobalamin transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cobalamin transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cobalamin transport ISO
Inferred from Sequence Orthology
more info
  
involved_in cobalt ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in microvillus IEA
Inferred from Electronic Annotation
more info
  
located_in microvillus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cobalamin binding intrinsic factor
Names
gastric intrinsic factor
intrinsic factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008118.3 → NP_032144.2  cobalamin binding intrinsic factor precursor

    See identical proteins and their annotated locations for NP_032144.2

    Status: VALIDATED

    Source sequence(s)
    AK078933
    Consensus CDS
    CCDS29609.1
    UniProtKB/Swiss-Prot
    P52787, Q8C5C1
    Related
    ENSMUSP00000025585.4, ENSMUST00000025585.4
    Conserved Domains (2) summary
    pfam01122
    Location:24 → 306
    Cobalamin_bind; Eukaryotic cobalamin-binding protein
    pfam14478
    Location:341 → 415
    DUF4430; Domain of unknown function (DUF4430)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    11724907..11740811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526688.2 → XP_006526751.1  cobalamin binding intrinsic factor isoform X1

    Conserved Domains (1) summary
    pfam01122
    Location:8 → 307
    Cobalamin_bind; Eukaryotic cobalamin-binding protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52787.2 GenPept UniProtKB/Swiss-Prot:P52787

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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