ADRA1D adrenoceptor alpha 1D [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADRA1Dprovided by HGNC
Official Full Name: adrenoceptor alpha 1Dprovided by HGNC
Primary source: HGNC:HGNC:280
See related: Ensembl:ENSG00000171873 MIM:104219; AllianceGenome:HGNC:280
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DAR; ADRA1; ADRA1A; ADRA1R; ALPHA1; dJ779E11.2
Summary: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]
Expression: Biased expression in prostate (RPKM 2.3), spleen (RPKM 0.8) and 10 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20p13

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (4220630..4249287, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (4254950..4283627, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (4201277..4229934, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional Involvement of ADRA1D in Cutaneous Melanoma Progression and Angiogenesis.
Title: Functional Involvement of ADRA1D in Cutaneous Melanoma Progression and Angiogenesis.
Characterization of heteromeric complexes between chemokine (C-X-C motif) receptor 4 and alpha1-adrenergic receptors utilizing intermolecular bioluminescence resonance energy transfer assays.
Title: Characterization of heteromeric complexes between chemokine (C-X-C motif) receptor 4 and α(1)-adrenergic receptors utilizing intermolecular bioluminescence resonance energy transfer assays.
N-glycosylation of alpha1D-adrenergic receptor N-terminal domain is required for correct trafficking, function, and biogenesis.
Title: N-glycosylation of α(1D)-adrenergic receptor N-terminal domain is required for correct trafficking, function, and biogenesis.
The roles of adrenoceptor alpha 1D phosphorylation sites/clusters were investigated. Carboxyl terminus phosphorylation seems to control receptor's membrane localization. Intracellular loop 3 mutation caused agonist-induced sustained ERK1/2 activation.
Title: Distinct phosphorylation sites/clusters in the carboxyl terminus regulate α(1D)-adrenergic receptor subcellular localization and signaling.
ADRA1 expression was greater on vascular smooth muscle in burn scars than in unscarred tissue, and greater on dermal nerve fibres, blood vessels and fibroblasts in keloid scars than in either burn scars or unscarred skin.
Title: Up-regulation of α(1)-adrenoceptors in burn and keloid scars.
Hetero-oligomerization of a1B/D-adrenergic receptor with the chemokine (C-X-C motif) receptor 4:atypical chemokine receptor 3 heteromeric complex is required for a1B/Dadrenergic receptor function.
Title: α(1)-Adrenergic Receptors Function Within Hetero-Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C-X-C motif) Receptor 4 in Vascular Smooth Muscle Cells.
processing of the ADRA1D NT domain is a physiological mechanism employed by cells to generate a functional ADRA1D isoform with optimal pharmacodynamic properties.
Title: Endogenous N-terminal Domain Cleavage Modulates α1D-Adrenergic Receptor Pharmacodynamics.
expression of carboxyl terminus-truncated alpha1D-adrenoceptors alters ERK and p38 phosphorylation state.
Title: Carboxyl terminus-truncated α1D-adrenoceptors inhibit the ERK pathway.
Immunoreactivity for ADRA2D was densely distributed in submucosal glands of nasal turbinates.
Title: Immunohistochemical localization of alpha and beta adrenergic receptors in the human nasal turbinate.
In conclusion, our work clarified some cellular aspects promoted by alpha1D-AR activity modulation and supports a further pharmacological approach in the cure of hormone-refractory PC, by targeting specifically this AR subtype
Title: A selective alpha1D-adrenoreceptor antagonist inhibits human prostate cancer cell proliferation and motility "in vitro".

Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-M76446 (e-PCR)
- UniSTS:6677

STS-M76446 (e-PCR)
- UniSTS:9611

RH64141 (e-PCR)
- UniSTS:29855

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables alpha1-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron-glial cell signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vasoconstriction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: alpha-1D adrenergic receptor

Names: adrenergic, alpha -1D-, receptor; adrenergic, alpha-1A-, receptor; alpha-1A adrenergic receptor; alpha-1D adrenoceptor; alpha-1D adrenoreceptor; alpha-adrenergic receptor 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000678.4 → NP_000669.1 alpha-1D adrenergic receptor

See identical proteins and their annotated locations for NP_000669.1

Status: REVIEWED

Source sequence(s)

AL121675, AL357040, S70782, U03864

Consensus CDS

CCDS13079.1

UniProtKB/Swiss-Prot

P25100, Q9NPY0

UniProtKB/TrEMBL

B0ZBE0

Related

ENSP00000368766.4, ENST00000379453.6

Conserved Domains (1) summary

cd15327
Location:97 → 413

7tmA_alpha1D_AR; alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors