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SSO_RS03895 minichromosome maintenance protein MCM [ Saccharolobus solfataricus P2 ]

Gene ID: 1455038, updated on 31-Mar-2024

Summary

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Gene symbol
SSO_RS03895
Gene description
minichromosome maintenance protein MCM
Locus tag
SSO_RS03895
Gene type
protein coding
Organism
Saccharolobus solfataricus P2 (strain: P2)
Lineage
Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae; Saccharolobus
Old locus tag
SSO0774
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Genomic context

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Sequence:
NC_002754.1 (658336..660396)

NC_002754.1Genomic Context describing neighboring genes Neighboring gene ORC1-type DNA replication protein Neighboring gene THUMP domain-containing protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase Neighboring gene AAA family ATPase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002754.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology. Slaymaker IM, et al. Nucleic Acids Res, 2013 Mar 1. PMID 23361460, Free PMC Article
  2. The glutamate switch is present in all seven clades of AAA+ protein. Mogni ME, et al. Biochemistry, 2009 Sep 22. PMID 19702328
  3. Crystal structure of a near-full-length archaeal MCM: functional insights for an AAA+ hexameric helicase. Brewster AS, et al. Proc Natl Acad Sci U S A, 2008 Dec 23. PMID 19073923, Free PMC Article
  4. Structural analysis of the Sulfolobus solfataricus MCM protein N-terminal domain. Liu W, et al. Nucleic Acids Res, 2008 Jun. PMID 18417534, Free PMC Article
  5. Amino acids of the Sulfolobus solfataricus mini-chromosome maintenance-like DNA helicase involved in DNA binding/remodeling. Pucci B, et al. J Biol Chem, 2004 Nov 19. PMID 15371413

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A newly identified function of MCM to change DNA topology may imply a wider functional role for MCM in DNA metabolisms in Sulfolobus solfataricus.
    Title: Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology.
  2. A highly conserved threonine residue acts as a glutamate switch in the replicative helicase, MCM, and thus reveals that the glutamate switch is a feature common to all seven AAA+ clades.
    Title: The glutamate switch is present in all seven clades of AAA+ protein.
  3. GINS is important in coordinating the architecture of the replication fork and provides a mechanism to couple progression of the MCM helicase on the leading strand with priming events on the lagging strand.
    Title: GINS, a central nexus in the archaeal DNA replication fork.
  4. 4.35-A crystal structure of the near-full-length ssoMCM; mutational analysis of residues at the intersubunit interfaces and around the side channels demonstrates their critical roles for hexamerization and helicase function
    Title: Crystal structure of a near-full-length archaeal MCM: functional insights for an AAA+ hexameric helicase.
  5. MCM can tolerate catalytically inactive subunits and still function as a helicase, leading us to propose a semisequential model for helicase activity of this complex.
    Title: ATPase site architecture and helicase mechanism of an archaeal MCM.
  6. specific amino acids of the Sulfolobus solfataricus MCM-like DNA helicase are involved in DNA binding/remodeling
    Title: Amino acids of the Sulfolobus solfataricus mini-chromosome maintenance-like DNA helicase involved in DNA binding/remodeling.
Submit: New GeneRIF Correction

General protein information

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Preferred Names
minichromosome maintenance protein MCM

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002754.1 Reference assembly

    Range
    658336..660396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_009991364.1 minichromosome maintenance protein MCM [Saccharolobus solfataricus]

    See identical proteins and their annotated locations for WP_009991364.1

    UniProtKB/Swiss-Prot
    Q9UXG1
    UniProtKB/TrEMBL
    A0A0E3K0Z7, D0KTH9
    Conserved Domains (1) summary
    COG1241
    Location:11 → 686
    Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UXG1.1