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HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1 like 2 [ Homo sapiens (human) ]

Gene ID: 144983, updated on 3-Nov-2024

Summary

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Official Symbol
HNRNPA1L2provided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein A1 like 2provided by HGNC
Primary source
HGNC:HGNC:27067
See related
Ensembl:ENSG00000139675 AllianceGenome:HGNC:27067
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytoplasm and nucleus. Predicted to be part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary (RPKM 119.2), bone marrow (RPKM 68.3) and 25 other tissues See more
Orthologs
all
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Genomic context

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See HNRNPA1L2 in Genome Data Viewer
Location:
13q14.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (52617525..52643773)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (51832997..51859241)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (53191660..53217908)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene cytoskeleton associated protein 2 Neighboring gene long intergenic non-protein coding RNA 345 Neighboring gene TPTE2 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 15313 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7793 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7794 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:53226721-53227222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7795 Neighboring gene SUGT1 divergent transcript Neighboring gene SGT1 homolog, MIS12 kinetochore complex assembly cochaperone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. H3.3-G34W in giant cell tumor of bone functionally aligns with the exon choice repressor hnRNPA1L2. Lee E, et al. Cancer Gene Ther, 2024 Aug. PMID 38811797, Free PMC Article
  2. HTR1A Inhibits the Progression of Triple-Negative Breast Cancer via TGF-β Canonical and Noncanonical Pathways. Liu Q, et al. Adv Sci (Weinh), 2022 Apr. PMID 35199941, Free PMC Article
  3. SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243. Murai Y, et al. Cancer Res, 2021 Jun 1. PMID 33863777, Free PMC Article
  4. Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2. Miluzio A, et al. EBioMedicine, 2023 Jan. PMID 36584595, Free PMC Article
  5. Disruption of the lamin A and matrin-3 interaction by myopathic LMNA mutations. Depreux FF, et al. Hum Mol Genet, 2015 Aug 1. PMID 25948554, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. H3.3-G34W in giant cell tumor of bone functionally aligns with the exon choice repressor hnRNPA1L2.
    Title: H3.3-G34W in giant cell tumor of bone functionally aligns with the exon choice repressor hnRNPA1L2.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102957

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein A1-like 2
Names
hnRNP A1-like 2
hnRNP core protein A1-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011724.3 → NP_001011724.1  heterogeneous nuclear ribonucleoprotein A1-like 2

    See identical proteins and their annotated locations for NP_001011724.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK094423, AL137058, BX477483, CD523364
    Consensus CDS
    CCDS31980.1
    UniProtKB/Swiss-Prot
    Q32P51, Q5TBS2
    UniProtKB/TrEMBL
    Q0VAC0
    Conserved Domains (3) summary
    pfam11627
    Location:255 → 292
    HnRNPA1; Nuclear factor hnRNPA1
    cd12761
    Location:12 → 92
    RRM1_hnRNPA1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins
    cl17169
    Location:105 → 184
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_001011725.3 → NP_001011725.1  heterogeneous nuclear ribonucleoprotein A1-like 2

    See identical proteins and their annotated locations for NP_001011725.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL137058, BQ425201, BX477483
    Consensus CDS
    CCDS31980.1
    UniProtKB/Swiss-Prot
    Q32P51, Q5TBS2
    UniProtKB/TrEMBL
    Q0VAC0
    Conserved Domains (3) summary
    pfam11627
    Location:255 → 292
    HnRNPA1; Nuclear factor hnRNPA1
    cd12761
    Location:12 → 92
    RRM1_hnRNPA1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins
    cl17169
    Location:105 → 184
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_001389320.1 → NP_001376249.1  heterogeneous nuclear ribonucleoprotein A1-like 2

    Status: VALIDATED

    Source sequence(s)
    AL137058, BC108266
    Consensus CDS
    CCDS31980.1
    UniProtKB/Swiss-Prot
    Q32P51, Q5TBS2
    UniProtKB/TrEMBL
    Q0VAC0
    Related
    ENSP00000350090.2, ENST00000357495.5
    Conserved Domains (3) summary
    pfam11627
    Location:255 → 292
    HnRNPA1; Nuclear factor hnRNPA1
    cd12761
    Location:12 → 92
    RRM1_hnRNPA1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins
    cl17169
    Location:105 → 184
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    52617525..52643773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    51832997..51859241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32P51.2 GenPept UniProtKB/Swiss-Prot:Q32P51

Gene LinkOut

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Chemical Information
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