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Ganab alpha glucosidase 2 alpha neutral subunit [ Mus musculus (house mouse) ]

Gene ID: 14376, updated on 2-Nov-2024

Summary

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Official Symbol
Ganabprovided by MGI
Official Full Name
alpha glucosidase 2 alpha neutral subunitprovided by MGI
Primary source
MGI:MGI:1097667
See related
Ensembl:ENSMUSG00000071650 AllianceGenome:MGI:1097667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G2an; GluII; mKIAA0088
Summary
Enables glucan 1,3-alpha-glucosidase activity. Involved in N-glycan processing. Part of glucosidase II complex. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in polycystic kidney disease; polycystic kidney disease 3; and polycystic liver disease. Orthologous to human GANAB (glucosidase II alpha subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 61.9), placenta adult (RPKM 49.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ganab in Genome Data Viewer
Location:
19 A; 19 5.96 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8875440..8894098)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8898057..8916742)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1810009A15 gene Neighboring gene STARR-positive B cell enhancer ABC_E11017 Neighboring gene LBH domain containing 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:8967434-8967543 Neighboring gene STARR-positive B cell enhancer ABC_E4265 Neighboring gene integrator complex subunit 5 Neighboring gene STARR-seq mESC enhancer starr_45501 Neighboring gene predicted gene, 36629 Neighboring gene beta-1,3-glucuronyltransferase 3 Neighboring gene echinoderm microtubule associated protein like 3 Neighboring gene rod outer segment membrane protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ganab Haploinsufficiency Does Not Cause Polycystic Kidney Disease or Polycystic Liver Disease in Mice.
    Title: Ganab Haploinsufficiency Does Not Cause Polycystic Kidney Disease or Polycystic Liver Disease in Mice.
  2. progression of neuropathologic and Behavioral abnormalities in a Pompe disease mouse model (6neo/6neo) that displays many features of the human disease
    Title: Temporal neuropathologic and behavioral phenotype of 6neo/6neo Pompe disease mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4)  1 citation
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC144011, MGC144012

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Glc2Man9GlcNAc2 oligosaccharide glucosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-glucosidase activity ISO
Inferred from Sequence Orthology
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables glucan 1,3-alpha-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucan 1,3-alpha-glucosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucan 1,3-alpha-glucosidase activity ISO
Inferred from Sequence Orthology
more info
  
enables glucan 1,3-alpha-glucosidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glucosidase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-glycan processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in N-glycan processing ISO
Inferred from Sequence Orthology
more info
  
involved_in N-glycan processing ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within N-glycan processing TAS
Traceable Author Statement
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
 PubMed 
part_of glucosidase II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glucosidase II complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of glucosidase II complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of glucosidase II complex ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in melanosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neutral alpha-glucosidase AB
Names
alpha-glucosidase 2
carbohydrate processing enzyme of the endoplasmic reticulum
glucosidase II alpha-subunit
glucosidase II subunit alpha
NP_001280550.1
NP_001397240.1
NP_032086.1
XP_006526740.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293621.2 → NP_001280550.1  neutral alpha-glucosidase AB isoform 2 precursor

    See identical proteins and their annotated locations for NP_001280550.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC129217
    Consensus CDS
    CCDS89335.1
    UniProtKB/Swiss-Prot
    O08794, Q149A6, Q80U81, Q8BHN3, Q9CS53
    Related
    ENSMUSP00000158122.2, ENSMUST00000235274.2
    Conserved Domains (3) summary
    cd06603
    Location:384 → 851
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:242 → 384
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam01055
    Location:365 → 810
    Glyco_hydro_31; Glycosyl hydrolases family 31

  2. NM_001410311.1 → NP_001397240.1  neutral alpha-glucosidase AB isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC129217

  3. NM_008060.3 → NP_032086.1  neutral alpha-glucosidase AB isoform 1 precursor

    See identical proteins and their annotated locations for NP_032086.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC129217
    Consensus CDS
    CCDS29557.1
    UniProtKB/TrEMBL
    A1A4T2
    Related
    ENSMUSP00000093965.4, ENSMUST00000096246.5
    Conserved Domains (3) summary
    cd06603
    Location:406 → 873
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:264 → 406
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam01055
    Location:387 → 832
    Glyco_hydro_31; Glycosyl hydrolases family 31

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    8875440..8894098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526677.2 → XP_006526740.1  neutral alpha-glucosidase AB isoform X1

    Conserved Domains (2) summary
    cd06603
    Location:309 → 776
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:167 → 309
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHN3.1 GenPept UniProtKB/Swiss-Prot:Q8BHN3

Gene LinkOut

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