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SPMIP5 sperm microtubule inner protein 5 [ Homo sapiens (human) ]

Gene ID: 143379, updated on 5-Mar-2024

Summary

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Official Symbol
SPMIP5provided by HGNC
Official Full Name
sperm microtubule inner protein 5provided by HGNC
Primary source
HGNC:HGNC:28500
See related
Ensembl:ENSG00000165863 AllianceGenome:HGNC:28500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C10orf82
Expression
Biased expression in testis (RPKM 14.6), ovary (RPKM 2.0) and 1 other tissue See more
Orthologs
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Genomic context

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See SPMIP5 in Genome Data Viewer
Location:
10q25.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (116662211..116670282, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (117556531..117564614, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (118421722..118429793, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902510 Neighboring gene pancreatic lipase related protein 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:118393650-118394849 Neighboring gene pancreatic lipase related protein 2 (gene/pseudogene) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118405699-118406228 Neighboring gene HSPA12A antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 10762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118441833-118442334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118442335-118442834 Neighboring gene heat shock protein family A (Hsp70) member 12A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118450610-118451348 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118453631-118454602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118501942-118502646 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118502647-118503350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118526330-118526895 Neighboring gene ribosomal protein L5 pseudogene 27 Neighboring gene uncharacterized LOC105378498

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structural specializations of the sperm tail. Leung MR, et al. Cell, 2023 Jun 22. PMID 37327785, Free PMC Article
  2. Genome-scale RNAi screen for host factors required for HIV replication. Zhou H, et al. Cell Host Microbe, 2008 Nov 13. PMID 18976975
  3. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article
  5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of chromosome 10 open reading frame 82 (C10orf82) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ40268, MGC33547

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sperm-associated microtubule inner protein 5
Names
sperm associated microtubule inner protein 5
uncharacterized protein C10orf82

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330142.3 → NP_001317071.1  sperm-associated microtubule inner protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC016825, BC021737, BX117017, BX537582, HY204705
    Consensus CDS
    CCDS81510.1
    UniProtKB/Swiss-Prot
    B3KUM9, D3DRC3, K7EKP3, Q8WW14

  2. NM_001350930.2 → NP_001337859.1  sperm-associated microtubule inner protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC016825, AI218030, AI797771, BX106852, BX117017, BX537582, HY204705
    Consensus CDS
    CCDS81510.1
    UniProtKB/Swiss-Prot
    B3KUM9, D3DRC3, K7EKP3, Q8WW14

  3. NM_001350931.2 → NP_001337860.1  sperm-associated microtubule inner protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC021737, BX117017, BX537582, DB451139, HY204705
    Consensus CDS
    CCDS81510.1
    UniProtKB/Swiss-Prot
    B3KUM9, D3DRC3, K7EKP3, Q8WW14
    Related
    ENSP00000465712.1, ENST00000588184.2

  4. NM_144661.4 → NP_653262.1  sperm-associated microtubule inner protein 5 isoform 1

    See identical proteins and their annotated locations for NP_653262.1

    Status: VALIDATED

    Source sequence(s)
    BC021737
    Consensus CDS
    CCDS7596.1
    UniProtKB/Swiss-Prot
    Q8WW14
    Related
    ENSP00000358212.3, ENST00000369210.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    116662211..116670282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424663.1 → XP_047280619.1  sperm-associated microtubule inner protein 5 isoform X4

  2. XM_011539342.3 → XP_011537644.1  sperm-associated microtubule inner protein 5 isoform X2

    See identical proteins and their annotated locations for XP_011537644.1

  3. XM_011539341.2 → XP_011537643.1  sperm-associated microtubule inner protein 5 isoform X2

    See identical proteins and their annotated locations for XP_011537643.1

  4. XM_011539343.4 → XP_011537645.1  sperm-associated microtubule inner protein 5 isoform X3

  5. XM_011539340.4 → XP_011537642.1  sperm-associated microtubule inner protein 5 isoform X1

  6. XM_011539346.4 → XP_011537648.1  sperm-associated microtubule inner protein 5 isoform X5

    See identical proteins and their annotated locations for XP_011537648.1

  7. XM_011539347.4 → XP_011537649.1  sperm-associated microtubule inner protein 5 isoform X6

  8. XM_011539344.4 → XP_011537646.1  sperm-associated microtubule inner protein 5 isoform X5

    See identical proteins and their annotated locations for XP_011537646.1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791790.1 Reference GRCh38.p14 PATCHES

    Range
    73207..81278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333106.1 → XP_054189081.1  sperm-associated microtubule inner protein 5 isoform X4

  2. XM_054333104.1 → XP_054189079.1  sperm-associated microtubule inner protein 5 isoform X2

  3. XM_054333103.1 → XP_054189078.1  sperm-associated microtubule inner protein 5 isoform X2

  4. XM_054333102.1 → XP_054189077.1  sperm-associated microtubule inner protein 5 isoform X1

  5. XM_054333105.1 → XP_054189080.1  sperm-associated microtubule inner protein 5 isoform X3

  6. XM_054333107.1 → XP_054189082.1  sperm-associated microtubule inner protein 5 isoform X5

  7. XM_054333108.1 → XP_054189083.1  sperm-associated microtubule inner protein 5 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    117556531..117564614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364919.1 → XP_054220894.1  sperm-associated microtubule inner protein 5 isoform X4

  2. XM_054364917.1 → XP_054220892.1  sperm-associated microtubule inner protein 5 isoform X2

  3. XM_054364916.1 → XP_054220891.1  sperm-associated microtubule inner protein 5 isoform X2

  4. XM_054364915.1 → XP_054220890.1  sperm-associated microtubule inner protein 5 isoform X1

  5. XM_054364918.1 → XP_054220893.1  sperm-associated microtubule inner protein 5 isoform X3

  6. XM_054364921.1 → XP_054220896.1  sperm-associated microtubule inner protein 5 isoform X5

  7. XM_054364920.1 → XP_054220895.1  sperm-associated microtubule inner protein 5 isoform X5

  8. XM_054364922.1 → XP_054220897.1  sperm-associated microtubule inner protein 5 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WW14.3 GenPept UniProtKB/Swiss-Prot:Q8WW14

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