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Ftl2-ps ferritin light polypeptide 2, pseudogene [ Mus musculus (house mouse) ]

Gene ID: 14337, updated on 18-Sep-2024

Summary

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Official Symbol
Ftl2-psprovided by MGI
Official Full Name
ferritin light polypeptide 2, pseudogeneprovided by MGI
Primary source
MGI:MGI:95590
See related
AllianceGenome:MGI:95590
Gene type
pseudo
RefSeq status
INFERRED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ftl; Ftl2; Ftl-2
Summary
Predicted to enable ferric iron binding activity and ferrous iron binding activity. Predicted to be involved in intracellular sequestering of iron ion. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in basal ganglia disease; hyperferritinemia-cataract syndrome; neurodegeneration with brain iron accumulation 3; and neurodegenerative disease. Orthologous to human FTL (ferritin light chain). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Ftl2-ps in Genome Data Viewer
Location:
4 D2.2; 4 58.94 cM
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (125397873..125398811)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (125504080..125505018)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40247 Neighboring gene STARR-seq mESC enhancer starr_11366 Neighboring gene predicted gene, 32756 Neighboring gene STARR-seq mESC enhancer starr_11372 Neighboring gene glutamate receptor, ionotropic, kainate 3 Neighboring gene microRNA 692-2 Neighboring gene STARR-seq mESC enhancer starr_11375 Neighboring gene predicted gene, 32807 Neighboring gene predicted gene, 54257

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A second ferritin L subunit is encoded by an intronless gene in the mouse. Renaudie F, et al. Mamm Genome, 1992. PMID 1543909
  2. Role of H and L subunits in mouse ferritin. Rucker P, et al. J Biol Chem, 1996 Dec 27. PMID 8969195
  3. Expression of H and L ferritin mRNAs in mouse small intestine. Gérard B, et al. Exp Cell Res, 1996 Oct 10. PMID 8892964
  4. Cellular distribution of iron, transferrin, and ferritin in the hypotransferrinemic (Hp) mouse brain. Dickinson TK, et al. J Comp Neurol, 1995 Apr 24. PMID 7636015
  5. Brain and retinal ferroportin 1 dysregulation in polycythaemia mice. Iacovelli J, et al. Brain Res, 2009 Sep 15. PMID 19596281, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Other Names

  • ferritin L subunit 2
  • ferritin light chain 2, pseudogene
  • ferritin subunit LG

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ferric iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferric iron binding IEA
Inferred from Electronic Annotation
more info
  
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
  
enables iron ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in intracellular iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in autolysosome IEA
Inferred from Electronic Annotation
more info
  
located_in autophagosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
part_of ferritin complex ISO
Inferred from Sequence Orthology
more info
  
part_of ferritin complex ISS
Inferred from Sequence or Structural Similarity
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029382.1 

    Range
    101..1039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    125397873..125398811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_008049.2: Suppressed sequence

    Description
    NM_008049.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49945.2 GenPept UniProtKB/Swiss-Prot:P49945

Gene LinkOut

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