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ptk2ab protein tyrosine kinase 2ab [ Danio rerio (zebrafish) ]

Gene ID: 142986, updated on 2-Nov-2024

Summary

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Official Symbol
ptk2abprovided by ZNC
Official Full Name
protein tyrosine kinase 2abprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020114-1
See related
Ensembl:ENSDARG00000004672 AllianceGenome:ZFIN:ZDB-GENE-020114-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fak; ptk2; fak1a; ptk2a; ptk2.1; zgc:66114; wu:fa18c04
Summary
Predicted to enable ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in regulation of convergent extension involved in gastrulation. Acts upstream of or within with a positive effect on midbrain-hindbrain boundary morphogenesis. Acts upstream of or within lens fiber cell morphogenesis and regulation of protein localization. Predicted to be located in several cellular components, including cytoskeleton; focal adhesion; and plasma membrane. Is expressed in eye; notochord; segmental plate; somite; and vertical myoseptum. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See ptk2ab in Genome Data Viewer
Location:
chromosome: 16
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (30737278..30869732, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (30779351..30911845, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 210 member Ab Neighboring gene low density lipoprotein receptor class A domain containing 4b Neighboring gene DENN/MADD domain containing 3b Neighboring gene solute carrier family 45 member 4b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Basal constriction during midbrain-hindbrain boundary morphogenesis is mediated by Wnt5b and focal adhesion kinase. Gutzman JH, et al. Biol Open, 2018 Nov 13. PMID 30305282, Free PMC Article
  2. Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart. Hirth S, et al. PLoS One, 2016. PMID 26954676, Free PMC Article
  3. Mutations in laminin alpha 1 result in complex, lens-independent ocular phenotypes in zebrafish. Semina EV, et al. Dev Biol, 2006 Nov 1. PMID 16973147
  4. Retinotopic mapping requires focal adhesion kinase-mediated regulation of growth cone adhesion. Woo S, et al. J Neurosci, 2009 Nov 4. PMID 19890008, Free PMC Article
  5. Activity and distribution of paxillin, focal adhesion kinase, and cadherin indicate cooperative roles during zebrafish morphogenesis. Crawford BD, et al. Mol Biol Cell, 2003 Aug. PMID 12925747, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data support a crucial role for miR-27 in promoting chondrogenic differentiation in the pharyngeal arches through regulation of FAK.
    Title: miR-27 regulates chondrogenesis by suppressing focal adhesion kinase during pharyngeal arch development.
  2. findings highlight an essential role of Paxillin and FAK in controlling cardiac contractility via the recruitment of Vinculin to mechano-sensitive sites in cardiomyocytes.
    Title: Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart.
  3. Data indicate that focal adhesion kinase (FAK) activity may be a mediator of the integrin alpha5/Fn1 interaction during zebrafish lens fiber morphogenesis.
    Title: Integrin α5/fibronectin1 and focal adhesion kinase are required for lens fiber morphogenesis in zebrafish.
  4. Focal adhesion kinase (FAK) mediates regulation of growth cone adhesion in the optic tectum of zebrafish.
    Title: Retinotopic mapping requires focal adhesion kinase-mediated regulation of growth cone adhesion.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC66114

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lens fiber cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within_positive_effect midbrain-hindbrain boundary morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within_positive_effect midbrain-hindbrain boundary morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cellular component organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of convergent extension involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein localization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal complex assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
focal adhesion kinase 1
Names
faka
focal adhesion kinase
protein tyrosine kinase 2.1
protein tyrosine kinase 2a
NP_571871.1
XP_005158222.1
XP_009290686.1
XP_068069970.1
XP_068069971.1
XP_068069972.1
XP_068069973.1
XP_068069974.1
XP_068069975.1
XP_068069976.1
XP_068069977.1
XP_068069978.1
XP_068069979.1
XP_068069980.1
XP_068069981.1
XP_068069982.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131796.1 → NP_571871.1  focal adhesion kinase 1

    See identical proteins and their annotated locations for NP_571871.1

    Status: PROVISIONAL

    Source sequence(s)
    AF348085
    UniProtKB/TrEMBL
    Q98SN4
    Related
    ENSDARP00000042715.7, ENSDART00000042716.9
    Conserved Domains (6) summary
    cd05056
    Location:417 → 686
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 358
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:143 → 248
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:914 → 1042
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:424 → 678
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    30737278..30869732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068213876.1 → XP_068069977.1  focal adhesion kinase 1 isoform X9

    Related
    ENSDARP00000156652.1, ENSDART00000190168.1

  2. XM_068213871.1 → XP_068069972.1  focal adhesion kinase 1 isoform X3

    Related
    ENSDARP00000155999.1, ENSDART00000190444.1

  3. XM_005158165.5 → XP_005158222.1  focal adhesion kinase 1 isoform X12

    UniProtKB/TrEMBL
    A0A8M2B4I9
    Conserved Domains (6) summary
    cd05056
    Location:455 → 724
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:74 → 296
    B41; Band 4.1 homologues
    cd13190
    Location:292 → 396
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:181 → 286
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:952 → 1080
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:462 → 716
    Pkinase_Tyr; Protein tyrosine kinase

  4. XM_068213874.1 → XP_068069975.1  focal adhesion kinase 1 isoform X6

  5. XM_068213877.1 → XP_068069978.1  focal adhesion kinase 1 isoform X10

    Related
    ENSDARP00000109075.3, ENSDART00000128158.4

  6. XM_068213872.1 → XP_068069973.1  focal adhesion kinase 1 isoform X4

  7. XM_068213878.1 → XP_068069979.1  focal adhesion kinase 1 isoform X11

  8. XM_068213873.1 → XP_068069974.1  focal adhesion kinase 1 isoform X5

  9. XM_009292411.4 → XP_009290686.1  focal adhesion kinase 1 isoform X8

    UniProtKB/TrEMBL
    A0A2R8RR02, A0A8M3B1R9
    Related
    ENSDARP00000150959.1, ENSDART00000191106.1
    Conserved Domains (6) summary
    cd05056
    Location:468 → 737
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:74 → 296
    B41; Band 4.1 homologues
    cd13190
    Location:292 → 396
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:181 → 286
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:965 → 1093
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:475 → 729
    Pkinase_Tyr; Protein tyrosine kinase

  10. XM_068213875.1 → XP_068069976.1  focal adhesion kinase 1 isoform X7

  11. XM_068213869.1 → XP_068069970.1  focal adhesion kinase 1 isoform X1

  12. XM_068213870.1 → XP_068069971.1  focal adhesion kinase 1 isoform X2

    Related
    ENSDARP00000149861.1, ENSDART00000191321.1

  13. XM_068213880.1 → XP_068069981.1  focal adhesion kinase 1 isoform X14

  14. XM_068213879.1 → XP_068069980.1  focal adhesion kinase 1 isoform X13

  15. XM_068213881.1 → XP_068069982.1  focal adhesion kinase 1 isoform X15

Nucleotide Protein Strain
Heading Accession and Version

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