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ASB14 ankyrin repeat and SOCS box containing 14 [ Homo sapiens (human) ]

Gene ID: 142686, updated on 3-Apr-2024

Summary

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Official Symbol
ASB14provided by HGNC
Official Full Name
ankyrin repeat and SOCS box containing 14provided by HGNC
Primary source
HGNC:HGNC:19766
See related
Ensembl:ENSG00000239388 AllianceGenome:HGNC:19766
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2008]
Expression
Ubiquitous expression in heart (RPKM 1.8), bone marrow (RPKM 1.0) and 25 other tissues See more
Orthologs
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Genomic context

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See ASB14 in Genome Data Viewer
Location:
3p14.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (57268342..57292685, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (57308608..57332970, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (57302370..57326713, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene interleukin 17 receptor D Neighboring gene uncharacterized LOC105377101 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:57192947-57193632 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:57193633-57194316 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14479 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:57218732-57218927 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:57233699-57234296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19986 Neighboring gene HESX homeobox 1 Neighboring gene uncharacterized LOC105377102 Neighboring gene adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 Neighboring gene MPRA-validated peak4664 silencer Neighboring gene uncharacterized LOC124909384 Neighboring gene MPRA-validated peak4666 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:57358479-57359002 Neighboring gene dynein axonemal heavy chain 12 Neighboring gene NANOG hESC enhancer GRCh37_chr3:57372950-57373478 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:57402873-57403048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:57434949-57435862 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. Kohroki J, et al. FEBS Lett, 2005 Dec 19. PMID 16325183
  2. MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment. Kumar S, et al. Cell Rep, 2019 Feb 12. PMID 30759391, Free PMC Article
  3. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535
  4. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. Andresen CA, et al. J Biol Chem, 2014 Jan 24. PMID 24337577, Free PMC Article
  5. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Dias Neto E, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10737800, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp313L0121

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 14
Names
ankyrin repeat domain-containing SOCS box protein Asb-14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142733.3 → NP_001136205.2  ankyrin repeat and SOCS box protein 14 isoform 1

    See identical proteins and their annotated locations for NP_001136205.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC093928, AL832472
    Consensus CDS
    CCDS46856.2
    UniProtKB/Swiss-Prot
    A6NK59, C9JX97, Q8WXK2, Q92816
    Related
    ENSP00000419199.1, ENST00000487349.6
    Conserved Domains (4) summary
    cd00204
    Location:116 → 236
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03730
    Location:529 → 585
    SOCS_ASB14; SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
    sd00045
    Location:182 → 213
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:57 → 147
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_130387.5 → NP_569058.1  ankyrin repeat and SOCS box protein 14 isoform 2

    See identical proteins and their annotated locations for NP_569058.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF403032, AL832472, BE004392
    UniProtKB/Swiss-Prot
    A6NK59
    Conserved Domains (4) summary
    cd00204
    Location:29 → 156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03730
    Location:244 → 300
    SOCS_ASB14; SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
    pfam12796
    Location:34 → 129
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:31 → 68
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    57268342..57292685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005737.3 → XP_016861226.1  ankyrin repeat and SOCS box protein 14 isoform X1

    UniProtKB/Swiss-Prot
    A6NK59, C9JX97, Q8WXK2, Q92816
    Conserved Domains (4) summary
    cd00204
    Location:116 → 236
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03730
    Location:529 → 585
    SOCS_ASB14; SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
    sd00045
    Location:182 → 213
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:57 → 147
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_017005736.3 → XP_016861225.1  ankyrin repeat and SOCS box protein 14 isoform X1

    UniProtKB/Swiss-Prot
    A6NK59, C9JX97, Q8WXK2, Q92816
    Conserved Domains (4) summary
    cd00204
    Location:116 → 236
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03730
    Location:529 → 585
    SOCS_ASB14; SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
    sd00045
    Location:182 → 213
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:57 → 147
    Ank_2; Ankyrin repeats (3 copies)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    57308608..57332970 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345309.1 → XP_054201284.1  ankyrin repeat and SOCS box protein 14 isoform X1

  2. XM_054345308.1 → XP_054201283.1  ankyrin repeat and SOCS box protein 14 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NK59.2 GenPept UniProtKB/Swiss-Prot:A6NK59

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