Foxd4 forkhead box D4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Foxd4provided by MGI
Official Full Name: forkhead box D4provided by MGI
Primary source: MGI:MGI:1347467
See related: Ensembl:ENSMUSG00000051490 AllianceGenome:MGI:1347467
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fkh2; FREAC5
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; embryo endoderm; embryo mesoderm; lung; and neural ectoderm. Orthologous to several human genes including FOXD4 (forkhead box D4). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human all
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Genomic context

Location:: 19 B; 19 19.86 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (24876307..24878380, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (24898943..24901016, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We demonstrate that mouse and human homologs of Foxd4l1 have similar functional domains compared to the frog protein, as well as conserved transcriptional activities when expressed in Xenopus embryos and blastomere explants.
Title: Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

Foxd4 (e-PCR), detects polymorphism
- UniSTS:143135

X86368 (e-PCR)
- UniSTS:160818

RH139093 (e-PCR)
- UniSTS:221179

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: forkhead box protein D4

Names: FREAC-5; forkhead homolog 2; forkhead-related protein FKHL9; forkhead-related transcription factor 5; transcription factor FKH-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008022.3 → NP_032048.1 forkhead box protein D4

See identical proteins and their annotated locations for NP_032048.1

Status: VALIDATED

Source sequence(s)

AC123930

Consensus CDS

CCDS29715.1

UniProtKB/Swiss-Prot

B2RRJ0, Q60688, Q61573

Related

ENSMUSP00000058575.3, ENSMUST00000058600.4

Conserved Domains (2) summary

PRK12323
Location:204 → 293

PRK12323; DNA polymerase III subunit gamma/tau

cd20048
Location:103 → 198

FH_FOXD4-like; Forkhead (FH) domain found in Forkhead box protein D4 (FOXD4) and similar proteins