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Fkbp2 FK506 binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 14227, updated on 28-Oct-2024

Summary

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Official Symbol
Fkbp2provided by MGI
Official Full Name
FK506 binding protein 2provided by MGI
Primary source
MGI:MGI:95542
See related
Ensembl:ENSMUSG00000056629 AllianceGenome:MGI:95542
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mFKBP2; mFKBP13
Summary
Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding and protein peptidyl-prolyl isomerization. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in central nervous system and retina. Orthologous to human FKBP2 (FKBP prolyl isomerase 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 24.7), placenta adult (RPKM 23.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fkbp2 in Genome Data Viewer
Location:
19 A; 19 5.12 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6955105..6957832, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6977737..6980464, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene phospholipase C, beta 3 Neighboring gene predicted gene, 52400 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7050464-7050926 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 14B Neighboring gene predicted gene, 51400 Neighboring gene predicted gene, 54053 Neighboring gene vascular endothelial growth factor B Neighboring gene DnaJ heat shock protein family (Hsp40) member C4 Neighboring gene STARR-positive B cell enhancer ABC_E1971

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rapamycin inhibits vascular smooth muscle cell migration. Poon M, et al. J Clin Invest, 1996 Nov 15. PMID 8941644, Free PMC Article
  2. Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1. Hendrickson BA, et al. Gene, 1993 Dec 8. PMID 7505249
  3. The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1. Walensky LD, et al. J Cell Biol, 1998 Apr 6. PMID 9531554, Free PMC Article
  4. Vti1b promotes TRPV1 sensitization during inflammatory pain. Sondermann JR, et al. Pain, 2019 Feb. PMID 30335684
  5. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP2
Names
13 kDa FK506-binding protein
13 kDa FKBP
PPIase FKBP2
immunophilin FKBP13
rotamase
NP_001159840.1
NP_001347215.1
NP_001347217.1
NP_032046.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166368.2 → NP_001159840.1  peptidyl-prolyl cis-trans isomerase FKBP2 precursor

    See identical proteins and their annotated locations for NP_001159840.1

    Status: VALIDATED

    Source sequence(s)
    AC120557, CF949699, DV655383
    Consensus CDS
    CCDS29515.1
    UniProtKB/Swiss-Prot
    P45878
    UniProtKB/TrEMBL
    Q3TND1, Q3UND3
    Related
    ENSMUSP00000136438.2, ENSMUST00000177752.9
    Conserved Domains (1) summary
    pfam00254
    Location:40 → 132
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  2. NM_001360286.1 → NP_001347215.1  peptidyl-prolyl cis-trans isomerase FKBP2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC120557, CF728525
    Consensus CDS
    CCDS29515.1
    UniProtKB/Swiss-Prot
    P45878
    UniProtKB/TrEMBL
    Q3TND1, Q3UND3
    Conserved Domains (1) summary
    pfam00254
    Location:40 → 132
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  3. NM_001360288.1 → NP_001347217.1  peptidyl-prolyl cis-trans isomerase FKBP2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC120557
    Consensus CDS
    CCDS29515.1
    UniProtKB/Swiss-Prot
    P45878
    UniProtKB/TrEMBL
    Q3TND1, Q3UND3
    Conserved Domains (1) summary
    pfam00254
    Location:40 → 132
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  4. NM_008020.4 → NP_032046.1  peptidyl-prolyl cis-trans isomerase FKBP2 precursor

    See identical proteins and their annotated locations for NP_032046.1

    Status: VALIDATED

    Source sequence(s)
    AC120557, AK144284, CF949699
    Consensus CDS
    CCDS29515.1
    UniProtKB/Swiss-Prot
    P45878
    UniProtKB/TrEMBL
    Q3TND1, Q3UND3
    Related
    ENSMUSP00000066839.9, ENSMUST00000070878.9
    Conserved Domains (1) summary
    pfam00254
    Location:40 → 132
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6955105..6957832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P45878.1 GenPept UniProtKB/Swiss-Prot:P45878

Gene LinkOut

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