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mzt1 putative mitotic spindle organizing protein Mzt1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 14218023, updated on 10-Oct-2024

Summary

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Official Symbol
mzt1
Official Full Name
putative mitotic spindle organizing protein Mzt1
Primary source
PomBase:SPAC9G1.15c
Locus tag
SPOM_SPAC9G1.15C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
tam4
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Genomic context

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See mzt1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (1985350..1985608, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Schizosaccharomyces specific protein Neighboring gene phospholipase Neighboring gene ncRNA Neighboring gene PAK-like GC kinase Sid1 Neighboring gene inositol polyphosphate phosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reconstitution of Microtubule Nucleation In Vitro Reveals Novel Roles for Mzt1. Leong SL, et al. Curr Biol, 2019 Jul 8. PMID 31287970, Free PMC Article
  2. Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3(Alp6). Dhani DK, et al. Mol Biol Cell, 2013 Nov. PMID 24006493, Free PMC Article
  3. Fission yeast MOZART1/Mzt1 is an essential γ-tubulin complex component required for complex recruitment to the microtubule organizing center, but not its assembly. Masuda H, et al. Mol Biol Cell, 2013 Sep. PMID 23885124, Free PMC Article
  4. Synergistic role of fission yeast Alp16GCP6 and Mzt1MOZART1 in γ-tubulin complex recruitment to mitotic spindle pole bodies and spindle assembly. Masuda H, et al. Mol Biol Cell, 2016 Jun 1. PMID 27053664, Free PMC Article
  5. Molecular model of fission yeast centrosome assembly determined by superresolution imaging. Bestul AJ, et al. J Cell Biol, 2017 Aug 7. PMID 28619713, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mzt1 is critical to stabilize Alp6, the S. pombe homolog of human gamma-TuSC protein GCP3, in an "interaction-competent" form within the gamma-TuSC. This is essential for the 34-40S ring-like "MGM" holocomplex to become a functional nucleator.
    Title: Reconstitution of Microtubule Nucleation In Vitro Reveals Novel Roles for Mzt1.
  2. Mzt1 therefore plays a unique role within the gamma-tubulin complex components in attachment of this complex to the major microtubule organizing center site.
    Title: Fission yeast MOZART1/Mzt1 is an essential γ-tubulin complex component required for complex recruitment to the microtubule organizing center, but not its assembly.
  3. Data suggest that Mzt1/Tam4 contributes to the microtubule-organizing centers (MTOCs) function through regulation of GCP3(Alp6).
    Title: Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3(Alp6).
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables spindle pole body anchor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule nucleation by interphase microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation by interphase microtubule organizing center IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule nucleation by spindle pole body IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in equatorial microtubule organizing center IDA
Inferred from Direct Assay
more info
 PubMed 
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma-tubulin ring complex ISO
Inferred from Sequence Orthology
more info
  
part_of gamma-tubulin small complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of gamma-tubulin small complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in inner plaque of mitotic spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in interphase microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in interphase microtubule organizing center IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle pole body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle pole body IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative mitotic spindle organizing protein Mzt1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1985350..1985608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001356041.2 → NP_001343106.2  putative mitotic spindle organizing protein Mzt1 [Schizosaccharomyces pombe]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    G2TRK7, P0CF96
    UniProtKB/TrEMBL
    A0AAN2L0G5
Nucleotide Protein
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