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Fbrs fibrosin [ Mus musculus (house mouse) ]

Gene ID: 14123, updated on 2-Nov-2024

Summary

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Official Symbol
Fbrsprovided by MGI
Official Full Name
fibrosinprovided by MGI
Primary source
MGI:MGI:104648
See related
Ensembl:ENSMUSG00000042423 AllianceGenome:MGI:104648
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbs; Fbs1
Summary
Enables growth factor activity. Acts upstream of or within positive regulation of fibroblast proliferation. Located in extracellular space. Orthologous to human FBRS (fibrosin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 21.0), spleen adult (RPKM 15.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fbrs in Genome Data Viewer
Location:
7 F3; 7 69.55 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127075925..127090685)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127478415..127491513)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20181 Neighboring gene zinc finger protein 688 Neighboring gene RIKEN cDNA B130055M24 gene Neighboring gene STARR-positive B cell enhancer ABC_E1095 Neighboring gene zinc finger protein 689 Neighboring gene STARR-seq mESC enhancer starr_20182 Neighboring gene STARR-seq mESC enhancer starr_20183 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134614302-134614485 Neighboring gene STARR-positive B cell enhancer ABC_E1742 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134621461-134621644 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134621862-134622045 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134623956-134624143 Neighboring gene proline rich 14 Neighboring gene microRNA 7060 Neighboring gene RIKEN cDNA 1700008J07 gene Neighboring gene STARR-seq mESC enhancer starr_20184 Neighboring gene STARR-seq mESC enhancer starr_20185 Neighboring gene Snf2-related CREBBP activator protein Neighboring gene small nucleolar RNA, H/ACA box 30

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and analysis of murine cDNA that encodes a fibrogenic lymphokine, fibrosin. Prakash S, et al. Proc Natl Acad Sci U S A, 1995 Mar 14. PMID 7892239, Free PMC Article
  2. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
  3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables growth factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
probable fibrosin-1
Names
fibrosin-1
probable fibrosin-1 long transcript protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010183.2 → NP_034313.2  probable fibrosin-1

    Status: VALIDATED

    Source sequence(s)
    AC136146
    Consensus CDS
    CCDS52408.2
    UniProtKB/TrEMBL
    A0A1N9PTV1
    Related
    ENSMUSP00000145783.3, ENSMUST00000205432.3
    Conserved Domains (1) summary
    pfam15336
    Location:602 → 782
    Auts2; Autism susceptibility gene 2 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    127075925..127090685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507348.5 → XP_006507411.1  probable fibrosin-1 isoform X1

    Conserved Domains (1) summary
    pfam15336
    Location:581 → 781
    Auts2; Autism susceptibility gene 2 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R089.2 GenPept UniProtKB/Swiss-Prot:Q8R089

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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