U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ADPRH ADP-ribosylarginine hydrolase [ Homo sapiens (human) ]

Gene ID: 141, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
ADPRHprovided by HGNC
Official Full Name
ADP-ribosylarginine hydrolaseprovided by HGNC
Primary source
HGNC:HGNC:269
See related
Ensembl:ENSG00000144843 MIM:603081; AllianceGenome:HGNC:269
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARH1; hARH1
Summary
The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, May 2014]
Expression
Ubiquitous expression in lung (RPKM 7.2), spleen (RPKM 6.0) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ADPRH in Genome Data Viewer
Location:
3q13.33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (119579492..119589945)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (122299217..122309670)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (119298339..119308792)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene CD80 molecule Neighboring gene CSRP2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20305 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20306 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20308 Neighboring gene Sharpr-MPRA regulatory region 12076 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20309 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20311 Neighboring gene uncharacterized LOC107986118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:119287249-119287750 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:119297943-119298444 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20314 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:119300593-119301792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20317 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:119319749-119320248 Neighboring gene phospholipase A1 member A Neighboring gene ReSE screen-validated silencer GRCh37_chr3:119331548-119331710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20318 Neighboring gene ribosomal protein L10 pseudogene 7

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Silencing of the maternally imprinted tumor suppressor ARHI contributes to follicular thyroid carcinogenesis. Weber F, et al. J Clin Endocrinol Metab, 2005 Feb. PMID 15546898
  2. The alpha 7 integrin as a target protein for cell surface mono-ADP-ribosylation in muscle cells. Zolkiewska A, et al. Adv Exp Med Biol, 1997. PMID 9193669
  3. Cloning, expression, purification and crystallization as well as X-ray fluorescence and preliminary X-ray diffraction analyses of human ADP-ribosylhydrolase 1. Kernstock S, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009 May 1. PMID 19407395, Free PMC Article
  4. (ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition. Rack JGM, et al. Cell Chem Biol, 2018 Dec 20. PMID 30472116, Free PMC Article
  5. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. Glowacki G, et al. Protein Sci, 2002 Jul. PMID 12070318, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. prerequisite for obtaining well diffracting crystals was the performance of X-ray fluorescence analysis on poorly diffracting apo hARH1 crystals, which revealed the presence of trace amounts of K(+) in the crystal
    Title: Cloning, expression, purification and crystallization as well as X-ray fluorescence and preliminary X-ray diffraction analyses of human ADP-ribosylhydrolase 1.
  2. Silencing of the putative maternally imprinted tumor suppressor gene ARHI serves as a key early event in follicular thyroid carcinogenesis.
    Title: Silencing of the maternally imprinted tumor suppressor ARHI contributes to follicular thyroid carcinogenesis.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP-ribosylarginine hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ADP-ribosylarginine hydrolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein de-ADP-ribosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein modification process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ADP-ribosylarginine hydrolase
Names
ADP-ribose-L-arginine cleaving enzyme
ADP-ribosylhydrolase ARH1
[Protein ADP-ribosylarginine] hydrolase
NP_001116.1
NP_001278878.1
NP_001278879.1
NP_001358021.1
NP_001378921.1
XP_047303432.1
XP_054201282.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001125.4 → NP_001116.1  ADP-ribosylarginine hydrolase isoform 1

    See identical proteins and their annotated locations for NP_001116.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein. Variants 1, 2 and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC073352, BC063883, BC074769
    Consensus CDS
    CCDS2990.1
    UniProtKB/Swiss-Prot
    B2R8H1, D3DN83, P54922
    UniProtKB/TrEMBL
    A8K6X2
    Related
    ENSP00000349496.3, ENST00000357003.8
    Conserved Domains (1) summary
    pfam03747
    Location:6 → 323
    ADP_ribosyl_GH; ADP-ribosylglycohydrolase

  2. NM_001291949.2 → NP_001278878.1  ADP-ribosylarginine hydrolase isoform 1

    See identical proteins and their annotated locations for NP_001278878.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC073352, AK291787, BC063883, BC074769
    Consensus CDS
    CCDS2990.1
    UniProtKB/Swiss-Prot
    B2R8H1, D3DN83, P54922
    UniProtKB/TrEMBL
    A8K6X2
    Related
    ENSP00000417528.1, ENST00000478927.5
    Conserved Domains (1) summary
    pfam03747
    Location:6 → 323
    ADP_ribosyl_GH; ADP-ribosylglycohydrolase

  3. NM_001291950.2 → NP_001278879.1  ADP-ribosylarginine hydrolase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two exons, differs in the 5' UTR, and initiates translation at a downstream start codon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC073352, AK304560, BC063883
    UniProtKB/Swiss-Prot
    P54922
    UniProtKB/TrEMBL
    B4E341
    Conserved Domains (1) summary
    pfam03747
    Location:25 → 216
    ADP_ribosyl_GH; ADP-ribosylglycohydrolase

  4. NM_001371092.1 → NP_001358021.1  ADP-ribosylarginine hydrolase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs from variant 1 in the 5' UTR. Variants 1, 2 and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC073352
    Consensus CDS
    CCDS2990.1
    UniProtKB/Swiss-Prot
    B2R8H1, D3DN83, P54922
    UniProtKB/TrEMBL
    A8K6X2
    Conserved Domains (1) summary
    pfam03747
    Location:6 → 323
    ADP_ribosyl_GH; ADP-ribosylglycohydrolase

  5. NM_001391992.1 → NP_001378921.1  ADP-ribosylarginine hydrolase isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC073352
    Consensus CDS
    CCDS2990.1
    UniProtKB/Swiss-Prot
    B2R8H1, D3DN83, P54922
    UniProtKB/TrEMBL
    A8K6X2
    Related
    ENSP00000420200.1, ENST00000478399.5
    Conserved Domains (1) summary
    pfam03747
    Location:6 → 323
    ADP_ribosyl_GH; ADP-ribosylglycohydrolase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    119579492..119589945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447476.1 → XP_047303432.1  ADP-ribosylarginine hydrolase isoform X1

    UniProtKB/Swiss-Prot
    B2R8H1, D3DN83, P54922

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    122299217..122309670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345307.1 → XP_054201282.1  ADP-ribosylarginine hydrolase isoform X1

    UniProtKB/Swiss-Prot
    B2R8H1, D3DN83, P54922
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54922.1 GenPept UniProtKB/Swiss-Prot:P54922

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous