U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cacng7 calcium voltage-gated channel auxiliary subunit gamma 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 140728, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
Cacng7provided by RGD
Official Full Name
calcium voltage-gated channel auxiliary subunit gamma 7provided by RGD
Primary source
RGD:628807
See related
EnsemblRapid:ENSRNOG00000056257 AllianceGenome:RGD:628807
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium channel regulator activity and voltage-gated calcium channel activity. Involved in positive regulation of dendrite extension; regulation of AMPA receptor activity; and regulation of mRNA stability. Located in cerebellar mossy fiber; early endosome; and neuronal cell body. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Orthologous to human CACNG7 (calcium voltage-gated channel auxiliary subunit gamma 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 67.8), Muscle (RPKM 6.6) and 2 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cacng7 in Genome Data Viewer
Location:
1q12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (74715483..74746669, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (65800059..65831246, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (64374547..64405380, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 6 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 8 Neighboring gene microRNA 935 Neighboring gene uncharacterized LOC103691003 Neighboring gene protein kinase C, gamma Neighboring gene myeloid-associated differentiation marker

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Stargazin-related protein γ₇ is associated with signalling endosomes in superior cervical ganglion neurons and modulates neurite outgrowth. Waithe D, et al. J Cell Sci, 2011 Jun 15. PMID 21610096, Free PMC Article
  2. The stargazin-related protein gamma 7 interacts with the mRNA-binding protein heterogeneous nuclear ribonucleoprotein A2 and regulates the stability of specific mRNAs, including CaV2.2. Ferron L, et al. J Neurosci, 2008 Oct 15. PMID 18923037, Free PMC Article
  3. TARP γ-7 selectively enhances synaptic expression of calcium-permeable AMPARs. Studniarczyk D, et al. Nat Neurosci, 2013 Sep. PMID 23872597, Free PMC Article
  4. Distribution of transmembrane AMPA receptor regulatory protein (TARP) isoforms in the rat spinal cord. Larsson M, et al. Neuroscience, 2013 Sep 17. PMID 23751177
  5. New transmembrane AMPA receptor regulatory protein isoform, gamma-7, differentially regulates AMPA receptors. Kato AS, et al. J Neurosci, 2007 May 2. PMID 17475805, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neurotransmitter receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in neurotransmitter receptor transport, postsynaptic endosome to lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of dendrite extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in postsynaptic neurotransmitter receptor diffusion trapping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of AMPA receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of AMPA receptor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of AMPA receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mRNA stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in transmission of nerve impulse IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AMPA glutamate receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of L-type voltage-gated calcium channel complex ISO
Inferred from Sequence Orthology
more info
  
part_of L-type voltage-gated calcium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cerebellar mossy fiber IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
voltage-dependent calcium channel gamma-7 subunit
Names
TARP gamma-7
calcium channel, voltage-dependent, gamma subunit 7
neuronal voltage-gated calcium channel gamma-7 subunit
transmembrane AMPAR regulatory protein gamma-7

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080695.2 → NP_542426.1  voltage-dependent calcium channel gamma-7 subunit

    See identical proteins and their annotated locations for NP_542426.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P62957
    UniProtKB/TrEMBL
    A6KS40
    Related
    ENSRNOP00000069074.1, ENSRNOT00000089944.3
    Conserved Domains (1) summary
    cl21598
    Location:16 → 195
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    74715483..74746669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082037.2 → XP_038937965.1  voltage-dependent calcium channel gamma-7 subunit isoform X1

    Conserved Domains (1) summary
    cl21598
    Location:18 → 142
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62957.1 GenPept UniProtKB/Swiss-Prot:P62957

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous