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NOL4L nucleolar protein 4 like [ Homo sapiens (human) ]

Gene ID: 140688, updated on 5-Mar-2024

Summary

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Official Symbol
NOL4Lprovided by HGNC
Official Full Name
nucleolar protein 4 likeprovided by HGNC
Primary source
HGNC:HGNC:16106
See related
Ensembl:ENSG00000197183 MIM:618893; AllianceGenome:HGNC:16106
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf112; C20orf113
Summary
Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 8.2), small intestine (RPKM 6.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
20q11.21
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (32443059..32585333, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (34167910..34310868, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (31030862..31173135, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30865306-30865816 Neighboring gene kinesin family member 3B Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:30914131-30915330 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12783 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17716 Neighboring gene ASXL transcriptional regulator 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31033225-31033886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31035799-31036300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31044389-31045304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31045305-31046220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31046221-31047136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31062343-31063114 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31064659-31065430 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12789 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12790 Neighboring gene uncharacterized LOC124904886 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31084748-31085264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31093704-31094386 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31094387-31095068 Neighboring gene uncharacterized LOC101929698 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:31098781-31099176 Neighboring gene VISTA enhancer hs2225 Neighboring gene Sharpr-MPRA regulatory region 5058 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12791 Neighboring gene uncharacterized LOC105372592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31124544-31125515 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31126487-31127458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31128887-31129392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31129393-31129898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31149672-31150323 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31151241-31151782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31158183-31158907 Neighboring gene Sharpr-MPRA regulatory region 4335 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31164325-31165278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31168247-31168946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12799 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12797 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12795 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12800 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17718 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31184984-31185484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31185485-31185985 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31186003-31186504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31189553-31190054 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12803 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31193059-31193558 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:31193901-31194067 Neighboring gene NOL4L divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31198315-31198930 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31198931-31199544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31206902-31207402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31211056-31211606 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12804 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:31226322-31226509 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31226763-31227262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31235460-31235960 Neighboring gene chromosome 20 open reading frame 203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31235961-31236461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17719 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12805 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31252264-31252832 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31252833-31253400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31254622-31255122 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31259991-31260490

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NOL4L, a novel nuclear protein, promotes cell proliferation and metastasis by enhancing the PI3K/AKT pathway in ovarian cancer. Lin F, et al. Biochem Biophys Res Commun, 2021 Jun 25. PMID 33940382
  2. Dominant-negative mechanism of leukemogenic PAX5 fusions. Kawamata N, et al. Oncogene, 2012 Feb 23. PMID 21765475, Free PMC Article
  3. LncRNA double homeobox A pseudogene 8 (DUXAP8) facilitates the progression of neuroblastoma and activates Wnt/β-catenin pathway via microRNA-29/nucleolar protein 4 like (NOL4L) axis. Nie L, et al. Brain Res, 2020 Nov 1. PMID 32522628
  4. CBFA2T2 and C20orf112: two novel fusion partners of RUNX1 in acute myeloid leukemia. Guastadisegni MC, et al. Leukemia, 2010 Aug. PMID 20520637
  5. Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex. Spruijt CG, et al. FEBS J, 2021 May. PMID 33283408, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA double homeobox A pseudogene 8 (DUXAP8) facilitates the progression of neuroblastoma and activates Wnt/beta-catenin pathway via microRNA-29/nucleolar protein 4 like (NOL4L) axis.
    Title: LncRNA double homeobox A pseudogene 8 (DUXAP8) facilitates the progression of neuroblastoma and activates Wnt/β-catenin pathway via microRNA-29/nucleolar protein 4 like (NOL4L) axis.
  2. NOL4L, a novel nuclear protein, promotes cell proliferation and metastasis by enhancing the PI3K/AKT pathway in ovarian cancer.
    Title: NOL4L, a novel nuclear protein, promotes cell proliferation and metastasis by enhancing the PI3K/AKT pathway in ovarian cancer.
  3. the leukemogenic PAX5-C20S fusion protein is a tetramer, which interacts extraordinarily stably with chromatin as determined by Fluorescence Recovery After Photobleaching in living cells
    Title: Dominant-negative mechanism of leukemogenic PAX5 fusions.
  4. report characterization of two chimeric transcripts identified in AML translocation cases involving CBFA2T2 and C20orf112
    Title: CBFA2T2 and C20orf112: two novel fusion partners of RUNX1 in acute myeloid leukemia.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • dJ1184F4.2, dJ1184F4.4, DKFZp566G1424

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
nucleolar protein 4-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256798.2 → NP_001243727.1  nucleolar protein 4-like isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1).
    Source sequence(s)
    AK056286, AL122043, AL133343, AL834520, BC023657, BC065370, BQ067609, BX281715
    Consensus CDS
    CCDS74718.1
    UniProtKB/TrEMBL
    A0A087X0N3
    Related
    ENSP00000483523.1, ENST00000621426.7
    Conserved Domains (1) summary
    pfam17921
    Location:131 → 185
    Integrase_H2C2; Integrase zinc binding domain

  2. NM_001351680.2 → NP_001338609.1  nucleolar protein 4-like isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL034550

  3. NM_080616.6 → NP_542183.2  nucleolar protein 4-like isoform 2

    See identical proteins and their annotated locations for NP_542183.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1. This results in translation initiation from an in-frame, downstream AUG, and an isofom (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK056286, AL122043, AL834520, BC038088, BC065370, BX281715
    Consensus CDS
    CCDS13202.1
    UniProtKB/Swiss-Prot
    Q5JYB7, Q6P0Y4, Q96MY1, Q9BR34, Q9NQF6
    Related
    ENSP00000352704.5, ENST00000359676.9

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    32443059..32585333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    34167910..34310868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96MY1.2 GenPept UniProtKB/Swiss-Prot:Q96MY1

Gene LinkOut

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