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Ewsr1 Ewing sarcoma breakpoint region 1 [ Mus musculus (house mouse) ]

Gene ID: 14030, updated on 2-Nov-2024

Summary

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Official Symbol
Ewsr1provided by MGI
Official Full Name
Ewing sarcoma breakpoint region 1provided by MGI
Primary source
MGI:MGI:99960
See related
Ensembl:ENSMUSG00000009079 AllianceGenome:MGI:99960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ews; Ewsh
Summary
Predicted to enable RNA binding activity; identical protein binding activity; and transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in Ewing sarcoma. Orthologous to human EWSR1 (EWS RNA binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 109.2), thymus adult (RPKM 93.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ewsr1 in Genome Data Viewer
Location:
11 A1; 11 3.22 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (5019687..5049314, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (5069687..5099107, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene adaptor protein complex AP-1, beta 1 subunit Neighboring gene predicted gene, 24958 Neighboring gene growth arrest-specific 2 like 1 Neighboring gene RAS-like, family 10, member A Neighboring gene STARR-positive B cell enhancer ABC_E8383 Neighboring gene STARR-positive B cell enhancer ABC_E11468 Neighboring gene rhomboid domain containing 3 Neighboring gene EMI domain containing 1 Neighboring gene predicted gene, 46266 Neighboring gene predicted gene, 39572

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In-depth proteome analysis of brain tissue from Ewsr1 knockout mouse by multiplexed isobaric tandem mass tag labeling. Jung JW, et al. Sci Rep, 2023 Sep 14. PMID 37709831, Free PMC Article
  2. Cloning and chromosome localization of the mouse Ews gene. Plougastel B, et al. Genomics, 1994 Sep 1. PMID 7829090
  3. The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells. Codrington R, et al. PLoS Biol, 2005 Aug. PMID 15974803, Free PMC Article
  4. Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development. Li H, et al. J Clin Invest, 2007 May. PMID 17415412, Free PMC Article
  5. A multifunctional protein EWS regulates the expression of Drosha and microRNAs. Kim KY, et al. Cell Death Differ, 2014 Jan. PMID 24185621, Free PMC Article

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In-depth proteome analysis of brain tissue from Ewsr1 knockout mouse by multiplexed isobaric tandem mass tag labeling.
    Title: In-depth proteome analysis of brain tissue from Ewsr1 knockout mouse by multiplexed isobaric tandem mass tag labeling.
  2. Gammaherpesvirus-mediated repression reveals EWSR1 to be a negative regulator of B cell responses.
    Title: Gammaherpesvirus-mediated repression reveals EWSR1 to be a negative regulator of B cell responses.
  3. Expression of the EWSR1-FLI1 fusion oncogene in pancreas cells drives pancreatic atrophy and lipomatosis.
    Title: Expression of the EWSR1-FLI1 fusion oncogene in pancreas cells drives pancreatic atrophy and lipomatosis.
  4. EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8.
    Title: EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8.
  5. Mouse EWSR1 is crucial for spermatid post-meiotic transcription and spermiogenesis.
    Title: Mouse EWSR1 is crucial for spermatid post-meiotic transcription and spermiogenesis.
  6. we show that loss of Stag2 cooperates with EWS-FLI1 and p53 mutation to promote sarcomagenesis in murine MSCs
    Title: Loss of Stag2 cooperates with EWS-FLI1 to transform murine Mesenchymal stem cells.
  7. the Fox transcription factor binding motif was frequently observed within EWS-FLI1 peaks and Foxq1 was identified as the cooperative partner that interacts with the EWS portion of EWS-FLI1.
    Title: EWS-FLI1 regulates a transcriptional program in cooperation with Foxq1 in mouse Ewing sarcoma.
  8. Authors found that FUS, EWS and TAF15 expression is differentially regulated during brain development, both in time and in space. In particular, this study identifies a fine-tuned regulation of FUS and EWS during neuronal differentiation.
    Title: Post-transcriptional regulation of FUS and EWS protein expression by miR-141 during neural differentiation.
  9. Gnai1 function is impaired in the spinal cord of Ews/Ewsr1 KO mice
    Title: Integrated analysis of omics data using microRNA-target mRNA network and PPI network reveals regulation of Gnai1 function in the spinal cord of Ews/Ewsr1 KO mice.
  10. EWS is normally O-GlcNAc glycosylated in the brain.
    Title: O-GlcNAc glycosylation stoichiometry of the FET protein family: only EWS is glycosylated with a high stoichiometry.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (9)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RNA-binding protein EWS
Names
Ewing sarcoma homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001283061.2 → NP_001269990.1  RNA-binding protein EWS isoform 1

    See identical proteins and their annotated locations for NP_001269990.1

    Status: VALIDATED

    Source sequence(s)
    AI852718, AK046434, BC068226, BY272748, CB205713
    UniProtKB/TrEMBL
    Q3UI30, Q6NVA3
    Conserved Domains (4) summary
    COG0724
    Location:354 → 455
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12533
    Location:361 → 444
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:522 → 543
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:518 → 547
    zf-RanBP; Zn-finger in Ran binding protein and others

  2. NM_001283062.2 → NP_001269991.1  RNA-binding protein EWS isoform 3

    Status: VALIDATED

    Source sequence(s)
    AI852718, AK046434, AK049743, AL645845, BY272748
    Consensus CDS
    CCDS70131.1
    UniProtKB/TrEMBL
    Q3UI30, Q5SUT0
    Related
    ENSMUSP00000073034.5, ENSMUST00000073308.11
    Conserved Domains (4) summary
    COG0724
    Location:316 → 417
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12533
    Location:323 → 406
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:484 → 505
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:480 → 509
    zf-RanBP; Zn-finger in Ran binding protein and others

  3. NM_001283063.2 → NP_001269992.1  RNA-binding protein EWS isoform 4

    See identical proteins and their annotated locations for NP_001269992.1

    Status: VALIDATED

    Source sequence(s)
    AK046434, AK147909, BY272748
    UniProtKB/TrEMBL
    Q3UGI7

  4. NM_001362612.1 → NP_001349541.1  RNA-binding protein EWS isoform 5

    Status: VALIDATED

    Source sequence(s)
    AI852718, AL645845
    UniProtKB/TrEMBL
    Q3UI30
    Conserved Domains (4) summary
    cd12533
    Location:367 → 450
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:528 → 549
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:524 → 553
    zf-RanBP; Zn-finger in Ran binding protein and others
    cl27818
    Location:52 → 159
    COG1615; Uncharacterized membrane protein, UPF0182 family [Function unknown]

  5. NM_001362613.1 → NP_001349542.1  RNA-binding protein EWS isoform 6

    Status: VALIDATED

    Source sequence(s)
    AI852718, AL645845
    UniProtKB/TrEMBL
    Q3UI30
    Conserved Domains (4) summary
    cd12533
    Location:367 → 450
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:528 → 549
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:524 → 553
    zf-RanBP; Zn-finger in Ran binding protein and others
    cl27818
    Location:53 → 160
    COG1615; Uncharacterized membrane protein, UPF0182 family [Function unknown]

  6. NM_001362614.1 → NP_001349543.1  RNA-binding protein EWS isoform 7

    Status: VALIDATED

    Source sequence(s)
    AI852718, AL645845
    Consensus CDS
    CCDS88124.1
    UniProtKB/TrEMBL
    Q3UI30, Q5SUS9
    Related
    ENSMUSP00000099994.4, ENSMUST00000102930.10
    Conserved Domains (4) summary
    cd12533
    Location:366 → 449
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:527 → 548
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:523 → 552
    zf-RanBP; Zn-finger in Ran binding protein and others
    cl27818
    Location:52 → 159
    COG1615; Uncharacterized membrane protein, UPF0182 family [Function unknown]

  7. NM_001362615.1 → NP_001349544.1  RNA-binding protein EWS isoform 8

    Status: VALIDATED

    Source sequence(s)
    AI852718, AL645845
    UniProtKB/TrEMBL
    Q3UI30
    Conserved Domains (4) summary
    cd12533
    Location:365 → 448
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:526 → 547
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:522 → 551
    zf-RanBP; Zn-finger in Ran binding protein and others
    cl26247
    Location:10 → 140
    DNA_pol3_delta2; DNA polymerase III, delta subunit

  8. NM_001362616.1 → NP_001349545.1  RNA-binding protein EWS isoform 9

    Status: VALIDATED

    Source sequence(s)
    AI852718, AL645845
    UniProtKB/TrEMBL
    Q3UI30
    Conserved Domains (4) summary
    cd12533
    Location:329 → 412
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:490 → 511
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:486 → 515
    zf-RanBP; Zn-finger in Ran binding protein and others
    cl27818
    Location:52 → 159
    COG1615; Uncharacterized membrane protein, UPF0182 family [Function unknown]

  9. NM_001362617.1 → NP_001349546.1  RNA-binding protein EWS isoform 10

    Status: VALIDATED

    Source sequence(s)
    AI852718, AL645845
    UniProtKB/TrEMBL
    Q3UI30
    Conserved Domains (2) summary
    cd12533
    Location:360 → 443
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    cl26247
    Location:10 → 135
    DNA_pol3_delta2; DNA polymerase III, delta subunit

  10. NM_001362618.1 → NP_001349547.1  RNA-binding protein EWS isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL645845

  11. NM_001362620.1 → NP_001349549.1  RNA-binding protein EWS isoform 12

    Status: VALIDATED

    Source sequence(s)
    AI852718, AL645845
    UniProtKB/TrEMBL
    Q9CRS5
    Conserved Domains (3) summary
    sd00025
    Location:183 → 204
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:179 → 208
    zf-RanBP; Zn-finger in Ran binding protein and others
    cd12533
    Location:22 → 105
    RRM_EWS; RNA recognition motif (RRM) found in vertebrate Ewing Sarcoma Protein (EWS)

  12. NM_001430960.1 → NP_001417889.1  RNA-binding protein EWS isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL645845

  13. NM_001430961.1 → NP_001417890.1  RNA-binding protein EWS isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL645845

  14. NM_007968.4 → NP_031994.2  RNA-binding protein EWS isoform 2

    See identical proteins and their annotated locations for NP_031994.2

    Status: VALIDATED

    Source sequence(s)
    AI852718, AK046434, AK151625, BY272748, CB205713
    Consensus CDS
    CCDS24396.1
    UniProtKB/Swiss-Prot
    Q61545, Q9D2P0
    UniProtKB/TrEMBL
    Q3UI30
    Related
    ENSMUSP00000078867.7, ENSMUST00000079949.13
    Conserved Domains (4) summary
    COG0724
    Location:353 → 454
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12533
    Location:360 → 443
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:521 → 542
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:517 → 546
    zf-RanBP; Zn-finger in Ran binding protein and others

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    5019687..5049314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514510.4 → XP_006514573.1  RNA-binding protein EWS isoform X3

    Conserved Domains (4) summary
    PRK14949
    Location:10 → 135
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    cd12533
    Location:361 → 444
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:522 → 543
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:519 → 547
    zf-RanBP; Zn-finger in Ran binding protein and others

  2. XM_017314255.3 → XP_017169744.1  RNA-binding protein EWS isoform X4

    Conserved Domains (4) summary
    PRK14949
    Location:10 → 135
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    cd12533
    Location:360 → 443
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:521 → 542
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:518 → 546
    zf-RanBP; Zn-finger in Ran binding protein and others

  3. XM_006514509.2 → XP_006514572.1  RNA-binding protein EWS isoform X2

    UniProtKB/TrEMBL
    Q3UI30
    Conserved Domains (4) summary
    PRK12438
    Location:52 → 159
    PRK12438; hypothetical protein; Provisional
    cd12533
    Location:366 → 449
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:527 → 548
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:524 → 552
    zf-RanBP; Zn-finger in Ran binding protein and others

  4. XM_006514508.2 → XP_006514571.1  RNA-binding protein EWS isoform X1

    UniProtKB/TrEMBL
    Q3UI30
    Conserved Domains (4) summary
    PRK12438
    Location:52 → 159
    PRK12438; hypothetical protein; Provisional
    cd12533
    Location:367 → 450
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:528 → 549
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:525 → 553
    zf-RanBP; Zn-finger in Ran binding protein and others

  5. XM_030245550.2 → XP_030101410.1  RNA-binding protein EWS isoform X5

    UniProtKB/TrEMBL
    Q5SUS8
    Related
    ENSMUSP00000091057.6, ENSMUST00000093365.12

RNA

  1. XR_001779874.1 RNA Sequence

  2. XR_003949296.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61545.2 GenPept UniProtKB/Swiss-Prot:Q61545

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