GPR119 G protein-coupled receptor 119 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPR119provided by HGNC
Official Full Name: G protein-coupled receptor 119provided by HGNC
Primary source: HGNC:HGNC:19060
See related: Ensembl:ENSG00000147262 MIM:300513; AllianceGenome:HGNC:19060
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GPCR2
Summary: This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010]
Orthologs: mouse all
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Genomic context

Location:: Xq26.1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (130379449..130385674, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (128698231..128704458, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (129513423..129519648, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPR116 overexpression correlates with poor prognosis in gastric cancer.
Title: GPR116 overexpression correlates with poor prognosis in gastric cancer.
Screening for bacterial enzymes synthesizing GPR119 agonist in cAMP-responsive cells.
Title: Screening for bacterial enzymes synthesizing GPR119 agonist in cAMP-responsive cells.
GPR119 Is a Potent Regulator of Human Sebocyte Biology.
Title: GPR119 Is a Potent Regulator of Human Sebocyte Biology.
GPR119 is the oleoyl-lysophosphatidylinositol receptor that is required for GLP-1 secretion in enteroendocrine cells.
Title: Oleoyl-lysophosphatidylinositol enhances glucagon-like peptide-1 secretion from enteroendocrine L-cells through GPR119.
Angelica dahurica extract-treated cells showed significant increases in GPR119 activation, intracellular cAMP levels, GLP-1 levels and glucose-stimulated insulin secretion as compared with controls
Title: Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119.
Describe novel small-molecule GPR119 agonists with high receptor selectivity and capacity to induce glucose-stimulated insulin secretion.
Title: Discovery and characterization of novel small molecule agonists of G protein-coupled receptor 119.
The GPR119 agonist, HD0471042 increased intracellular cAMP levels in stably human GPR119 expressing CHO cells.
Title: Novel GPR119 agonist HD0471042 attenuated type 2 diabetes mellitus.
Oxidized-LDL significantly induces lincRNA-DYNLRB2-2 expression, which promotes ABCA1-mediated cholesterol efflux and inhibits inflammation through GPR119 in THP-1 cells.
Title: A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis.
Replacement of the three methyl groups in 1 with metabolically stable moieties led to the identification of compound 34, a potent and efficacious GPR119 agonist with improved pharmacokinetic (PK) properties.
Title: Discovery and optimization of arylsulfonyl 3-(pyridin-2-yloxy)anilines as novel GPR119 agonists.
transfection of GLUTag cells with recombinant human GPR119 results in a constitutive and apparently ligand-independent increase of proglucagon gene promoter activity and proglucagon mRNA content.
Title: Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:482989

GPR119_2585 (e-PCR)
- UniSTS:468444

NoName (e-PCR)
- UniSTS:490481

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glucose-dependent insulinotropic receptor

Names: G-protein coupled receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016404.1 RefSeqGene

Range

5001..6193

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_178471.3 → NP_848566.1 glucose-dependent insulinotropic receptor

See identical proteins and their annotated locations for NP_848566.1

Status: REVIEWED

Source sequence(s)

AL035423

Consensus CDS

CCDS14625.1

UniProtKB/Swiss-Prot

Q495H7, Q4VBN3, Q8TDV5

Related

ENSP00000508182.1, ENST00000682440.1

Conserved Domains (1) summary

cd15104
Location:6 → 290

7tmA_GPR119_R_insulinotropic_receptor; G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors