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OTUD6A OTU deubiquitinase 6A [ Homo sapiens (human) ]

Gene ID: 139562, updated on 16-Apr-2024

Summary

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Official Symbol
OTUD6Aprovided by HGNC
Official Full Name
OTU deubiquitinase 6Aprovided by HGNC
Primary source
HGNC:HGNC:32312
See related
Ensembl:ENSG00000189401 MIM:300714; AllianceGenome:HGNC:32312
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DUBA2; HSHIN6
Summary
Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA2 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]
Orthologs
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Genomic context

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Location:
Xq13.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (70062457..70064179)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (68495808..68497530)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (69282307..69284029)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ectodysplasin A Neighboring gene microRNA 676 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:69306192-69306426 Neighboring gene acyl-CoA wax alcohol acyltransferase 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:69330633-69331832 Neighboring gene MT-CYB pseudogene 31 Neighboring gene MT-ND6 pseudogene 31

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ovarian tumor deubiquitinase 6A regulates cell proliferation via deubiquitination of nucleolin and caspase‑7. Kim SH, et al. Int J Oncol, 2022 Oct. PMID 36082810
  2. Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission. Shi L, et al. Mol Oncol, 2020 Dec. PMID 33070427, Free PMC Article
  3. OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR. Fu X, et al. Commun Biol, 2022 Mar 1. PMID 35233061, Free PMC Article
  4. Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc. Peng Y, et al. Cell Death Differ, 2022 Sep. PMID 35217790, Free PMC Article
  5. Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy. Zhao Y, et al. Cell Death Differ, 2022 Dec. PMID 35768646, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deubiquitinase OTUD6a drives cardiac inflammation and hypertrophy by deubiquitination of STING.
    Title: Deubiquitinase OTUD6a drives cardiac inflammation and hypertrophy by deubiquitination of STING.
  2. OTUD6A in tubular epithelial cells mediates angiotensin II-induced kidney injury by targeting STAT3.
    Title: OTUD6A in tubular epithelial cells mediates angiotensin II-induced kidney injury by targeting STAT3.
  3. Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy.
    Title: Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy.
  4. Ovarian tumor deubiquitinase 6A regulates cell proliferation via deubiquitination of nucleolin and caspase7.
    Title: Ovarian tumor deubiquitinase 6A regulates cell proliferation via deubiquitination of nucleolin and caspase‑7.
  5. Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc.
    Title: Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc.
  6. OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR.
    Title: OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR.
  7. Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission.
    Title: Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission.
  8. OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase.
    Title: OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25831

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein K11-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K27-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K27-linked deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K29-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K29-linked deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K33-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K33-linked deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
OTU domain-containing protein 6A
Names
HIN-6 protease
NP_997203.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207320.3 → NP_997203.1  OTU domain-containing protein 6A

    See identical proteins and their annotated locations for NP_997203.1

    Status: VALIDATED

    Source sequence(s)
    AK098697, AL158141
    Consensus CDS
    CCDS14395.1
    UniProtKB/Swiss-Prot
    B2RPB7, Q7L8S5
    Related
    ENSP00000339389.2, ENST00000338352.3
    Conserved Domains (2) summary
    COG5539
    Location:5 → 271
    COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
    pfam02338
    Location:147 → 269
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    70062457..70064179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    68495808..68497530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7L8S5.1 GenPept UniProtKB/Swiss-Prot:Q7L8S5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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