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ADGRG4 adhesion G protein-coupled receptor G4 [ Homo sapiens (human) ]

Gene ID: 139378, updated on 28-Oct-2024

Summary

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Official Symbol
ADGRG4provided by HGNC
Official Full Name
adhesion G protein-coupled receptor G4provided by HGNC
Primary source
HGNC:HGNC:18992
See related
Ensembl:ENSG00000156920 MIM:301085; AllianceGenome:HGNC:18992
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR17; GPR112; RP1-299I16
Summary
This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010]
Expression
Biased expression in duodenum (RPKM 1.3), small intestine (RPKM 0.8) and 2 other tissues See more
Orthologs
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Genomic context

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See ADGRG4 in Genome Data Viewer
Location:
Xq26.3
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (136300963..136416890)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (134609302..134725270)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (135383122..135499049)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1893 Neighboring gene MAP7 domain containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21026 Neighboring gene serine/threonine kinase 24 pseudogene 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:135434931-135436130 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:135468612-135469811 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21027 Neighboring gene HIV-1 Tat specific factor 1 Neighboring gene bombesin receptor subtype 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Exome sequencing identifies ADGRG4 G-protein-coupled receptors gene as a novel cancer biomarker in ovarian cancer patients from North India. Sharma M, et al. J Biochem Mol Toxicol, 2024 Mar. PMID 38462741
  2. The dimerized pentraxin-like domain of the adhesion G protein-coupled receptor 112 (ADGRG4) suggests function in sensing mechanical forces. Kieslich B, et al. J Biol Chem, 2023 Dec. PMID 37863265, Free PMC Article
  3. Getting from A to B-exploring the activation motifs of the class B adhesion G protein-coupled receptor subfamily G member 4/GPR112. Peeters MC, et al. FASEB J, 2016 May. PMID 26823453
  4. Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas. Leja J, et al. Mod Pathol, 2009 Feb. PMID 18953328
  5. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. Fredriksson R, et al. FEBS Lett, 2002 Nov 20. PMID 12435584

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exome sequencing identifies ADGRG4 G-protein-coupled receptors gene as a novel cancer biomarker in ovarian cancer patients from North India.
    Title: Exome sequencing identifies ADGRG4 G-protein-coupled receptors gene as a novel cancer biomarker in ovarian cancer patients from North India.
  2. The dimerized pentraxin-like domain of the adhesion G protein-coupled receptor 112 (ADGRG4) suggests function in sensing mechanical forces.
    Title: The dimerized pentraxin-like domain of the adhesion G protein-coupled receptor 112 (ADGRG4) suggests function in sensing mechanical forces.
  3. This study described the structure-function relationship of adhesion G protein-coupled receptors (ADGRs) using ADGRGr as a model receptor.
    Title: Getting from A to B-exploring the activation motifs of the class B adhesion G protein-coupled receptor subfamily G member 4/GPR112.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp781E1948

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adhesion G-protein coupled receptor G4
Names
G protein-coupled receptor 112
probable G-protein coupled receptor 112

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021219.1 RefSeqGene

    Range
    5001..120928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_153834.4 → NP_722576.3  adhesion G-protein coupled receptor G4 precursor

    See identical proteins and their annotated locations for NP_722576.3

    Status: REVIEWED

    Source sequence(s)
    AL161778, AY140954, AY882585
    Consensus CDS
    CCDS35409.1
    UniProtKB/Swiss-Prot
    A2A2J1, A2A2J2, Q5EGP2, Q86SM6, Q8IZF6
    Related
    ENSP00000377699.1, ENST00000394143.6
    Conserved Domains (4) summary
    pfam00002
    Location:2743 → 2982
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:2684 → 2727
    GPS; GPCR proteolysis site, GPS, motif
    pfam09786
    Location:1668 → 1909
    CytochromB561_N; Cytochrome B561, N terminal
    cl22861
    Location:28 → 210
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    136300963..136416890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531269.3 → XP_011529571.1  adhesion G-protein coupled receptor G4 isoform X1

    See identical proteins and their annotated locations for XP_011529571.1

    UniProtKB/Swiss-Prot
    A2A2J1, A2A2J2, Q5EGP2, Q86SM6, Q8IZF6
    Related
    ENSP00000377697.1, ENST00000394141.1
    Conserved Domains (4) summary
    pfam00002
    Location:2743 → 2982
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:2684 → 2727
    GPS; GPCR proteolysis site, GPS, motif
    pfam09786
    Location:1668 → 1909
    CytochromB561_N; Cytochrome B561, N terminal
    cl22861
    Location:28 → 210
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

  2. XM_047441830.1 → XP_047297786.1  adhesion G-protein coupled receptor G4 isoform X2

  3. XM_047441831.1 → XP_047297787.1  adhesion G-protein coupled receptor G4 isoform X4

  4. XM_011531271.3 → XP_011529573.1  adhesion G-protein coupled receptor G4 isoform X3

    Conserved Domains (4) summary
    pfam00002
    Location:2680 → 2919
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:2621 → 2664
    GPS; GPCR proteolysis site, GPS, motif
    pfam09786
    Location:1605 → 1846
    CytochromB561_N; Cytochrome B561, N terminal
    cl22861
    Location:2 → 147
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    134609302..134725270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326479.1 → XP_054182454.1  adhesion G-protein coupled receptor G4 isoform X1

    UniProtKB/Swiss-Prot
    A2A2J1, A2A2J2, Q5EGP2, Q86SM6, Q8IZF6

  2. XM_054326480.1 → XP_054182455.1  adhesion G-protein coupled receptor G4 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IZF6.2 GenPept UniProtKB/Swiss-Prot:Q8IZF6

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