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SPANXN3 SPANX family member N3 [ Homo sapiens (human) ]

Gene ID: 139067, updated on 5-Mar-2024

Summary

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Official Symbol
SPANXN3provided by HGNC
Official Full Name
SPANX family member N3provided by HGNC
Primary source
HGNC:HGNC:33176
See related
Ensembl:ENSG00000189252 MIM:300666; AllianceGenome:HGNC:33176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT11.8; SPANX-N3
Expression
Restricted expression toward testis (RPKM 9.9) See more
Orthologs
all
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Genomic context

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See SPANXN3 in Genome Data Viewer
Location:
Xq27.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (143508735..143517475, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (141818043..141826783, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (142596564..142605303, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MT-ND1 pseudogene 33 Neighboring gene MT-ND2 pseudogene 39 Neighboring gene MYCL pseudogene 3 Neighboring gene SLIT and NTRK like family member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. Westbrook VA, et al. Mol Hum Reprod, 2006 Nov. PMID 17012309
  2. The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids. Kouprina N, et al. Proc Natl Acad Sci U S A, 2004 Mar 2. PMID 14973187, Free PMC Article
  3. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Persaud A, et al. Mol Syst Biol, 2009. PMID 19953087, Free PMC Article
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049, Free PMC Article
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
sperm protein associated with the nucleus on the X chromosome N3
Names
cancer/testis antigen family 11, member 8
nuclear-associated protein SPAN-Xn3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009609.4 → NP_001009609.2  sperm protein associated with the nucleus on the X chromosome N3

    See identical proteins and their annotated locations for NP_001009609.2

    Status: VALIDATED

    Source sequence(s)
    BC062750, DQ336129
    Consensus CDS
    CCDS35418.1
    UniProtKB/Swiss-Prot
    Q0ZNK4, Q5MJ09
    Related
    ENSP00000359534.2, ENST00000370503.2
    Conserved Domains (1) summary
    pfam07458
    Location:1 → 95
    SPAN-X; Sperm protein associated with nucleus, mapped to X chromosome

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    143508735..143517475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029264.2 → XP_016884753.1  sperm protein associated with the nucleus on the X chromosome N3 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    141818043..141826783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326454.1 → XP_054182429.1  sperm protein associated with the nucleus on the X chromosome N3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5MJ09.2 GenPept UniProtKB/Swiss-Prot:Q5MJ09

Gene LinkOut

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