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GPAT4 glycerol-3-phosphate acyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 137964, updated on 3-Apr-2024

Summary

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Official Symbol
GPAT4provided by HGNC
Official Full Name
glycerol-3-phosphate acyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:20880
See related
Ensembl:ENSG00000158669 MIM:608143; AllianceGenome:HGNC:20880
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AGPAT6; LPAATZ; TSARG7; 1-AGPAT 6; LPAAT-zeta
Summary
Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]
Expression
Ubiquitous expression in endometrium (RPKM 10.2), adrenal (RPKM 10.1) and 25 other tissues See more
Orthologs
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Genomic context

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See GPAT4 in Genome Data Viewer
Location:
8p11.21
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (41578200..41625001)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (41851958..41898752)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (41435719..41482520)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27287 Neighboring gene GPAT4 and GINS4 antisense RNA 1 Neighboring gene uncharacterized LOC124901939 Neighboring gene GINS complex subunit 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:41424977-41425739 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:41430689-41430895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27289 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41451733-41452234 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41454165-41454665 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:41466108-41467307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27291 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19146 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:41510853-41511646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41513473-41514006 Neighboring gene NK6 homeobox 3 Neighboring gene microRNA 486-1 Neighboring gene microRNA 486-2 Neighboring gene ankyrin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes. Snogdal LS, et al. BMC Med Genet, 2013 Oct 25. PMID 24156295, Free PMC Article
  2. Molecular cloning and preliminary function study of a novel human gene, TSARG7, related to spermatogenesis. Tan XJ, et al. Yi Chuan Xue Bao, 2006 Apr. PMID 16625827
  3. Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family. Li D, et al. J Hum Genet, 2003. PMID 12938015
  4. Glycerol-3-phosphate Acyltransferase Isoform-4 (GPAT4) Limits Oxidation of Exogenous Fatty Acids in Brown Adipocytes. Cooper DE, et al. J Biol Chem, 2015 Jun 12. PMID 25918168, Free PMC Article
  5. GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis. Shan D, et al. J Lipid Res, 2010 Jul. PMID 20181984, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPAT4 activity requires CHP1 to be N-myristoylated, forming a key molecular interface between the two proteins, regulating glycerolipid metabolism.
    Title: CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4.
  2. None of the eleven AGPAT6 variants were robustly associated with type 2 diabetes in the Danish.
    Title: Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes.
  3. Results reveal a link between the lipogenic effects of insulin and microsomal GPAT3 and GPAT4, implying their importance in glycerolipid biosynthesis.
    Title: GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis.
  4. we have cloned a novel human gene and this gene may play an important role in human spermatogenesis and sexual maturation.
    Title: Molecular cloning and preliminary function study of a novel human gene, TSARG7, related to spermatogenesis.
  5. AGPAT6 is a microsomal GPAT, and we propose renaming this enzyme GPAT4.
    Title: AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp586M1819

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-acylglycerol-3-phosphate O-acyltransferase activity TAS
Traceable Author Statement
more info
  
enables glycerol-3-phosphate O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycerol-3-phosphate O-acyltransferase activity TAS
Traceable Author Statement
more info
  
enables sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in acyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in diacylglycerol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glandular epithelial cell maturation IEA
Inferred from Electronic Annotation
more info
  
involved_in lactation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in phosphatidylcholine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in triglyceride biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
glycerol-3-phosphate acyltransferase 4
Names
1-AGP acyltransferase 6
1-acyl-sn-glycerol-3-phosphate acyltransferase zeta
1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
glycerol-3-phosphate acyltransferase 6
lysophosphatidic acid acyltransferase zeta
testis spermatogenesis apoptosis-related protein 7
NP_001350126.1
NP_001350127.1
NP_848934.1
XP_047277326.1
XP_047277327.1
XP_047277328.1
XP_047277330.1
XP_054215737.1
XP_054215738.1
XP_054215739.1
XP_054215740.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363197.2 → NP_001350126.1  glycerol-3-phosphate acyltransferase 4 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC009630, AF406612, BU149203, BU620295, DB479618
    Consensus CDS
    CCDS6117.1
    UniProtKB/Swiss-Prot
    Q2TU73, Q86UL3, Q86V89
    Conserved Domains (1) summary
    cd07991
    Location:218 → 427
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

  2. NM_001363198.2 → NP_001350127.1  glycerol-3-phosphate acyltransferase 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009630, AF406612, BU149203, BU620295
    UniProtKB/TrEMBL
    Q8NDD3

  3. NM_178819.4 → NP_848934.1  glycerol-3-phosphate acyltransferase 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_848934.1

    Status: VALIDATED

    Source sequence(s)
    AC009630, AF406612, BU620295
    Consensus CDS
    CCDS6117.1
    UniProtKB/Swiss-Prot
    Q2TU73, Q86UL3, Q86V89
    Related
    ENSP00000380184.3, ENST00000396987.7
    Conserved Domains (1) summary
    cd07991
    Location:218 → 427
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    41578200..41625001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421370.1 → XP_047277326.1  glycerol-3-phosphate acyltransferase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q2TU73, Q86UL3, Q86V89

  2. XM_047421372.1 → XP_047277328.1  glycerol-3-phosphate acyltransferase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q2TU73, Q86UL3, Q86V89

  3. XM_047421371.1 → XP_047277327.1  glycerol-3-phosphate acyltransferase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q2TU73, Q86UL3, Q86V89

  4. XM_047421374.1 → XP_047277330.1  glycerol-3-phosphate acyltransferase 4 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    41851958..41898752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359762.1 → XP_054215737.1  glycerol-3-phosphate acyltransferase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q2TU73, Q86UL3, Q86V89

  2. XM_054359764.1 → XP_054215739.1  glycerol-3-phosphate acyltransferase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q2TU73, Q86UL3, Q86V89

  3. XM_054359763.1 → XP_054215738.1  glycerol-3-phosphate acyltransferase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q2TU73, Q86UL3, Q86V89

  4. XM_054359765.1 → XP_054215740.1  glycerol-3-phosphate acyltransferase 4 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86UL3.1 GenPept UniProtKB/Swiss-Prot:Q86UL3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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