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UBXN2B UBX domain protein 2B [ Homo sapiens (human) ]

Gene ID: 137886, updated on 2-Nov-2024

Summary

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Official Symbol
UBXN2Bprovided by HGNC
Official Full Name
UBX domain protein 2Bprovided by HGNC
Primary source
HGNC:HGNC:27035
See related
Ensembl:ENSG00000215114 MIM:610686; AllianceGenome:HGNC:27035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p37
Summary
Predicted to enable ubiquitin binding activity. Involved in establishment of mitotic spindle orientation; negative regulation of protein localization to centrosome; and positive regulation of mitotic centrosome separation. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and spindle pole centrosome. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 9.6), thyroid (RPKM 8.2) and 25 other tissues See more
Orthologs
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Genomic context

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See UBXN2B in Genome Data Viewer
Location:
8q12.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (58411361..58451501)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (58832480..58872635)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (59323920..59364060)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986945 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:59108481-59109680 Neighboring gene VISTA enhancer hs1364 Neighboring gene long intergenic non-protein coding RNA 3133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27407 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:59282662-59283206 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:59304090-59304590 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:59304591-59305091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:59308925-59309426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:59309427-59309926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:59350272-59350772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:59350773-59351273 Neighboring gene PTPN11 pseudogene 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:59404317-59405516 Neighboring gene CYP7A1 5' regulatory region Neighboring gene cytochrome P450 family 7 subfamily A member 1 Neighboring gene peptidylprolyl isomerase A pseudogene 85

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Phosphorylation of p37 is important for Golgi disassembly at mitosis. Kaneko Y, et al. Biochem Biophys Res Commun, 2010 Nov 5. PMID 20875789
  2. In silico prediction, characterization, docking studies and molecular dynamics simulation of human p97 in complex with p37 cofactor. Mirzadeh A, et al. BMC Mol Cell Biol, 2022 Sep 10. PMID 36088301, Free PMC Article
  3. Structural basis of ubiquitin-independent PP1 complex disassembly by p97. van den Boom J, et al. EMBO J, 2023 Jul 17. PMID 37264685, Free PMC Article
  4. Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study. Luca G, et al. J Sleep Res, 2013 Oct. PMID 23496005
  5. Altered cofactor regulation with disease-associated p97/VCP mutations. Zhang X, et al. Proc Natl Acad Sci U S A, 2015 Apr 7. PMID 25775548, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In silico prediction, characterization, docking studies and molecular dynamics simulation of human p97 in complex with p37 cofactor.
    Title: In silico prediction, characterization, docking studies and molecular dynamics simulation of human p97 in complex with p37 cofactor.
  2. human p37/p47 and their C. elegans orthologue UBXN-2 regulate centrosome function in prophase by limiting the recruitment of Aurora A
    Title: The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A.
  3. these results demonstrate that p37 phosphorylation on Serine-56 and Threonine-59 is important for Golgi disassembly at mitosis.
    Title: Phosphorylation of p37 is important for Golgi disassembly at mitosis.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of mitotic spindle orientation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in membrane fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein localization to centrosome IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nuclear membrane reassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitotic centrosome separation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole centrosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UBX domain-containing protein 2B
Names
NSFL1 cofactor p37
p97 cofactor p37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077619.2 → NP_001071087.1  UBX domain-containing protein 2B isoform 1

    See identical proteins and their annotated locations for NP_001071087.1

    Status: VALIDATED

    Source sequence(s)
    AK126300, BC113645, U79282
    Consensus CDS
    CCDS43741.1
    UniProtKB/Swiss-Prot
    B3KWZ3, Q14CS0
    Related
    ENSP00000382507.2, ENST00000399598.7
    Conserved Domains (2) summary
    cd01770
    Location:253 → 331
    p47_UBX; p47-like ubiquitin domain
    smart00553
    Location:140 → 232
    SEP; Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47

  2. NM_001330535.2 → NP_001317464.1  UBX domain-containing protein 2B isoform 2

    Status: VALIDATED

    Source sequence(s)
    BE502216, DA185219, DA242203
    Consensus CDS
    CCDS83297.1
    UniProtKB/TrEMBL
    E5RJ36
    Related
    ENSP00000428314.1, ENST00000523409.5
    Conserved Domains (1) summary
    cl02662
    Location:146 → 178
    SEP; SEP domain

  3. NM_001363181.1 → NP_001350110.1  UBX domain-containing protein 2B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK126300, BC113645, U79282
    Conserved Domains (2) summary
    cd01770
    Location:207 → 285
    p47_UBX; p47-like ubiquitin domain
    cl02662
    Location:146 → 182
    SEP; SEP domain

RNA

  1. NR_156456.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK126300, BC113645, DB337840, U79282

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    58411361..58451501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    58832480..58872635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14CS0.1 GenPept UniProtKB/Swiss-Prot:Q14CS0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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