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Elf1 E74 like ETS transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 13709, updated on 2-Nov-2024

Summary

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Official Symbol
Elf1provided by MGI
Official Full Name
E74 like ETS transcription factor 1provided by MGI
Primary source
MGI:MGI:107180
See related
Ensembl:ENSMUSG00000036461 AllianceGenome:MGI:107180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p70; Sts1; Elf-1; mElf-1
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of T cell receptor signaling pathway and regulation of cytokine production. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ELF1 (E74 like ETS transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 22.3), bladder adult (RPKM 13.4) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Elf1 in Genome Data Viewer
Location:
14 D3; 14 42.67 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (79718619..79819916)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (79481174..79582491)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene mitochondrial translational release factor 1 Neighboring gene kelch repeat and BTB (POZ) domain containing 7 Neighboring gene STARR-positive B cell enhancer ABC_E2429 Neighboring gene kelch repeat and BTB (POZ) domain containing 6 Neighboring gene WW domain binding protein 4 Neighboring gene nuclear encoded tRNA glutamic acid 4 (anticodon TTC) Neighboring gene claspin homolog pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr14:79915269-79915570 Neighboring gene STARR-positive B cell enhancer ABC_E9411 Neighboring gene STARR-positive B cell enhancer ABC_E9903 Neighboring gene STARR-seq mESC enhancer starr_37267 Neighboring gene STARR-positive B cell enhancer ABC_E2430 Neighboring gene SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) Neighboring gene chondromodulin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and expression of the murine Elf-1 cDNA. Davis JN, et al. Gene, 1996 Jun 1. PMID 8666284
  2. Expression pattern of the Ets-related transcription factor Elf-1. Bassuk AG, et al. Mol Med, 1998 Jun. PMID 10780882, Free PMC Article
  3. The 1.35 A resolution structure of the phosphatase domain of the suppressor of T-cell receptor signaling protein in complex with sulfate. Jakoncic J, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Jun 1. PMID 20516590, Free PMC Article
  4. E74-like factor 1 contributes to nerve trauma-induced nociceptive hypersensitivity through transcriptionally activating matrix metalloprotein-9 in dorsal root ganglion neurons. Zhang L, et al. Pain, 2023 Jan 1. PMID 35507368, Free PMC Article
  5. Identification of ETS domain proteins in murine T lymphocytes that interact with the Moloney murine leukemia virus enhancer. Gunther CV, et al. Mol Cell Biol, 1994 Nov. PMID 7935472, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation and motility in early pregnancy.
    Title: ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation and motility in early pregnancy.
  2. E74-like factor 1 contributes to nerve trauma-induced nociceptive hypersensitivity through transcriptionally activating matrix metalloprotein-9 in dorsal root ganglion neurons.
    Title: E74-like factor 1 contributes to nerve trauma-induced nociceptive hypersensitivity through transcriptionally activating matrix metalloprotein-9 in dorsal root ganglion neurons.
  3. Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression
    Title: Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression.
  4. Herein, the authors demonstrate that mice lacking Sts expression are significantly resistant to infection by the live vaccine strain of Francisella tularensis.
    Title: Increased Resistance to Intradermal Francisella tularensis LVS Infection by Inactivation of the Sts Phosphatases.
  5. Whereas the proportion of NK cells in Elf-1(-/-) mice was normal, the proportion of NKT cells was significantly reduced in the thymus and periphery of Elf-1(-/-) mice compared with wild-type mice.
    Title: Differential requirements for the Ets transcription factor Elf-1 in the development of NKT cells and NK cells.
  6. crystal structure of the phosphatase domain of Sts-1, Sts-1(PGM), was determined at pH 4.6.The asymmetric unit contains two independent molecules and each active site is occupied by a sulfate ion.
    Title: The 1.35 A resolution structure of the phosphatase domain of the suppressor of T-cell receptor signaling protein in complex with sulfate.
  7. The Sts-1,2 proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways.
    Title: The Sts proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways.
  8. These results suggest that several Ets factors, including Fli1 itself, are involved in the transcriptional regulation of Fli1 in lymphocytes.
    Title: Ets factors and a newly identified polymorphism regulate Fli1 promoter activity in lymphocytes.
  9. Results suggest that GATA-2, Fli-1 and Elf-1 are key components of an enhanceosome responsible for activating SCL transcription and establishing the transcriptional programme required for HSC formation.
    Title: Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of T cell receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cytokine production IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ETS-related transcription factor Elf-1
Names
E74-like factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286411.2 → NP_001273340.1  ETS-related transcription factor Elf-1 isoform 1

    See identical proteins and their annotated locations for NP_001273340.1

    Status: VALIDATED

    Source sequence(s)
    AC129216, AC151994
    Consensus CDS
    CCDS27301.1
    UniProtKB/Swiss-Prot
    Q60775
    UniProtKB/TrEMBL
    Q3U1B2, Q3V1H4
    Related
    ENSMUSP00000106459.2, ENSMUST00000110835.3
    Conserved Domains (2) summary
    smart00413
    Location:207 → 289
    ETS; erythroblast transformation specific domain
    pfam12310
    Location:2 → 111
    Elf-1_N; Transcription factor protein N terminal

  2. NM_001286412.2 → NP_001273341.1  ETS-related transcription factor Elf-1 isoform 2

    See identical proteins and their annotated locations for NP_001273341.1

    Status: VALIDATED

    Source sequence(s)
    AC129216, AC151994
    Consensus CDS
    CCDS88722.1
    UniProtKB/TrEMBL
    A0A2I3BPX9, Q3U1B2
    Related
    ENSMUSP00000153956.2, ENSMUST00000227192.2
    Conserved Domains (2) summary
    smart00413
    Location:170 → 252
    ETS; erythroblast transformation specific domain
    pfam12310
    Location:2 → 69
    Elf-1_N; Transcription factor protein N terminal

  3. NM_001422240.1 → NP_001409169.1  ETS-related transcription factor Elf-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC129216, AC151994
    UniProtKB/Swiss-Prot
    Q60775
    UniProtKB/TrEMBL
    Q3V1H4

  4. NM_001422241.1 → NP_001409170.1  ETS-related transcription factor Elf-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC129216, AC151994
    UniProtKB/Swiss-Prot
    Q60775
    UniProtKB/TrEMBL
    Q3V1H4

  5. NM_001422242.1 → NP_001409171.1  ETS-related transcription factor Elf-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC129216, AC151994
    UniProtKB/Swiss-Prot
    Q60775
    UniProtKB/TrEMBL
    Q3V1H4

  6. NM_001422243.1 → NP_001409172.1  ETS-related transcription factor Elf-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC129216, AC151994
    UniProtKB/TrEMBL
    A0A2I3BPX9

  7. NM_001422244.1 → NP_001409173.1  ETS-related transcription factor Elf-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC129216, AC151994

  8. NM_007920.5 → NP_031946.1  ETS-related transcription factor Elf-1 isoform 1

    See identical proteins and their annotated locations for NP_031946.1

    Status: VALIDATED

    Source sequence(s)
    AC129216, AC151994
    Consensus CDS
    CCDS27301.1
    UniProtKB/Swiss-Prot
    Q60775
    UniProtKB/TrEMBL
    Q3U1B2, Q3V1H4
    Related
    ENSMUSP00000046515.6, ENSMUST00000040131.13
    Conserved Domains (2) summary
    smart00413
    Location:207 → 289
    ETS; erythroblast transformation specific domain
    pfam12310
    Location:2 → 111
    Elf-1_N; Transcription factor protein N terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    79718619..79819916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60775.1 GenPept UniProtKB/Swiss-Prot:Q60775

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