U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Eef2k eukaryotic elongation factor-2 kinase [ Mus musculus (house mouse) ]

Gene ID: 13631, updated on 14-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Eef2kprovided by MGI
Official Full Name
eukaryotic elongation factor-2 kinaseprovided by MGI
Primary source
MGI:MGI:1195261
See related
Ensembl:ENSMUSG00000035064 AllianceGenome:MGI:1195261
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
eEF-2K
Summary
Enables calmodulin binding activity and elongation factor-2 kinase activity. Involved in regulation of protein autophosphorylation. Predicted to be located in dendritic spine. Predicted to be active in glutamatergic synapse and postsynaptic density. Is expressed in liver; lung; nervous system; and olfactory epithelium. Orthologous to human EEF2K (eukaryotic elongation factor 2 kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 19.4), colon adult (RPKM 10.7) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Eef2k in Genome Data Viewer
Location:
7 F2; 7 64.95 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (120442080..120506441)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (120842642..120907219)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene short chain dehydrogenase/reductase family 42E, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E6592 Neighboring gene STARR-positive B cell enhancer ABC_E1360 Neighboring gene STARR-positive B cell enhancer ABC_E10469 Neighboring gene nuclear encoded tRNA leucine 1 (anticodon TAG) Neighboring gene predicted gene, 36449 Neighboring gene predicted gene 15774 Neighboring gene STARR-positive B cell enhancer ABC_E2845 Neighboring gene STARR-positive B cell enhancer ABC_E6593 Neighboring gene nuclear encoded tRNA leucine 4 (anticodon AAG) Neighboring gene polymerase (RNA) III (DNA directed) polypeptide E

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Impairing eukaryotic elongation factor 2 kinase activity decreases atherosclerotic plaque formation. Zhang P, et al. Can J Cardiol, 2014 Dec. PMID 25475470, Free PMC Article
  2. Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine. Gschwendt M, et al. FEBS Lett, 1994 Jan 24. PMID 8307162
  3. Resveratrol regulates pathologic angiogenesis by a eukaryotic elongation factor-2 kinase-regulated pathway. Khan AA, et al. Am J Pathol, 2010 Jul. PMID 20472894, Free PMC Article
  4. Impaired associative taste learning and abnormal brain activation in kinase-defective eEF2K mice. Gildish I, et al. Learn Mem, 2012 Feb 24. PMID 22366775, Free PMC Article
  5. Germline quality control: eEF2K stands guard to eliminate defective oocytes. Chu HP, et al. Dev Cell, 2014 Mar 10. PMID 24582807, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Enhanced NK cell activation via eEF2K-mediated potentiation of the cGAS-STING pathway in hepatocellular carcinoma.
    Title: Enhanced NK cell activation via eEF2K-mediated potentiation of the cGAS-STING pathway in hepatocellular carcinoma.
  2. Control of CD4[+] T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase.
    Title: Control of CD4(+) T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase.
  3. Eukaryotic Elongation Factor 2 Kinase Activity Is Required for the Phenotypes of the Rpl24[Bst] Mouse.
    Title: Eukaryotic Elongation Factor 2 Kinase Activity Is Required for the Phenotypes of the Rpl24(Bst) Mouse.
  4. eEF2K promotes PD-L1 stabilization through inactivating GSK3beta in melanoma.
    Title: eEF2K promotes PD-L1 stabilization through inactivating GSK3β in melanoma.
  5. miRNA-193b-5p Suppresses Pancreatic Cancer Cell Proliferation, Invasion, Epithelial Mesenchymal Transition, and Tumor Growth by Inhibiting eEF2K.
    Title: miRNA-193b-5p Suppresses Pancreatic Cancer Cell Proliferation, Invasion, Epithelial Mesenchymal Transition, and Tumor Growth by Inhibiting eEF2K.
  6. [Effects of GSK3beta/eEF2K signaling pathway on pulmonary fibrosis in mice].
    Title: [Effects of GSK3β/eEF2K signaling pathway on pulmonary fibrosis in mice].
  7. Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic elongation factor 2 kinase (eEF2K).
    Title: Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic elongation factor 2 kinase (eEF2K).
  8. Elongation factor-2 kinase is a critical determinant of the fate and antitumor immunity of CD8(+) T cells.
    Title: Elongation factor-2 kinase is a critical determinant of the fate and antitumor immunity of CD8(+) T cells.
  9. Eukaryotic elongation factor 2 kinase regulates foam cell formation via translation of CD36.
    Title: Eukaryotic elongation factor 2 kinase regulates foam cell formation via translation of CD36.
  10. Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
    Title: Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (4)  1 citation

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
enables elongation factor-2 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables elongation factor-2 kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables elongation factor-2 kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables translation factor activity, RNA binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to anoxia IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to brain-derived neurotrophic factor stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to cAMP IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to calcium ion IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in myosin II filament disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of translation at postsynapse IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translation at postsynapse ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ischemia IEA
Inferred from Electronic Annotation
more info
  
involved_in response to prolactin IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
eukaryotic elongation factor 2 kinase
Names
calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase
eEF-2 kinase
eukaroytic elongation factor 2 kinase
NP_001254639.1
NP_001254640.1
NP_001399257.1
NP_001399258.1
NP_001399259.1
NP_001399260.1
NP_001399261.1
NP_001399262.1
NP_001399263.1
NP_031934.1
XP_036008548.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267710.2 → NP_001254639.1  eukaryotic elongation factor 2 kinase isoform a

    See identical proteins and their annotated locations for NP_001254639.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AC122214, AC122248
    Consensus CDS
    CCDS21796.1
    UniProtKB/Swiss-Prot
    O08796
    UniProtKB/TrEMBL
    Q7TPC7, Q8BNP6, Q8CEC8
    Related
    ENSMUSP00000102098.2, ENSMUST00000106489.9
    Conserved Domains (3) summary
    COG0790
    Location:492 → 688
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:502 → 535
    SLR; SLR repeat [structural motif]
    cd16967
    Location:102 → 317
    Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase

  2. NM_001267711.2 → NP_001254640.1  eukaryotic elongation factor 2 kinase isoform a

    See identical proteins and their annotated locations for NP_001254640.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AC122214, AC122248
    Consensus CDS
    CCDS21796.1
    UniProtKB/Swiss-Prot
    O08796
    UniProtKB/TrEMBL
    Q7TPC7, Q8BNP6, Q8CEC8
    Related
    ENSMUSP00000102097.2, ENSMUST00000106488.3
    Conserved Domains (3) summary
    COG0790
    Location:492 → 688
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:502 → 535
    SLR; SLR repeat [structural motif]
    cd16967
    Location:102 → 317
    Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase

  3. NM_001412328.1 → NP_001399257.1  eukaryotic elongation factor 2 kinase isoform a

    Status: VALIDATED

    Source sequence(s)
    AC122214, AC122248
    UniProtKB/Swiss-Prot
    O08796

  4. NM_001412329.1 → NP_001399258.1  eukaryotic elongation factor 2 kinase isoform a

    Status: VALIDATED

    Source sequence(s)
    AC122214, AC122248
    UniProtKB/Swiss-Prot
    O08796

  5. NM_001412330.1 → NP_001399259.1  eukaryotic elongation factor 2 kinase isoform a

    Status: VALIDATED

    Source sequence(s)
    AC122214, AC122248
    UniProtKB/Swiss-Prot
    O08796

  6. NM_001412331.1 → NP_001399260.1  eukaryotic elongation factor 2 kinase isoform b

    Status: VALIDATED

    Source sequence(s)
    AC122214, AC122248

  7. NM_001412332.1 → NP_001399261.1  eukaryotic elongation factor 2 kinase isoform c

    Status: VALIDATED

    Source sequence(s)
    AC122214, AC122248

  8. NM_001412333.1 → NP_001399262.1  eukaryotic elongation factor 2 kinase isoform c

    Status: VALIDATED

    Source sequence(s)
    AC122214, AC122248

  9. NM_001412334.1 → NP_001399263.1  eukaryotic elongation factor 2 kinase isoform d

    Status: VALIDATED

    Source sequence(s)
    AC122248

  10. NM_007908.5 → NP_031934.1  eukaryotic elongation factor 2 kinase isoform a

    See identical proteins and their annotated locations for NP_031934.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AC122214, AC122248
    Consensus CDS
    CCDS21796.1
    UniProtKB/Swiss-Prot
    O08796
    UniProtKB/TrEMBL
    Q7TPC7, Q8BNP6, Q8CEC8
    Related
    ENSMUSP00000046595.9, ENSMUST00000047875.16
    Conserved Domains (3) summary
    COG0790
    Location:492 → 688
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:502 → 535
    SLR; SLR repeat [structural motif]
    cd16967
    Location:102 → 317
    Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase

RNA

  1. NR_178189.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122214, AC122248

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    120442080..120506441
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152655.1 → XP_036008548.1  eukaryotic elongation factor 2 kinase isoform X4

    UniProtKB/TrEMBL
    Q8BNP6
    Conserved Domains (3) summary
    COG0790
    Location:351 → 547
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:361 → 394
    SLR; SLR repeat [structural motif]
    cd16967
    Location:1 → 176
    Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08796.1 GenPept UniProtKB/Swiss-Prot:O08796

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous