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C6orf141 chromosome 6 open reading frame 141 [ Homo sapiens (human) ]

Gene ID: 135398, updated on 5-Mar-2024

Summary

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Official Symbol
C6orf141provided by HGNC
Official Full Name
chromosome 6 open reading frame 141provided by HGNC
Primary source
HGNC:HGNC:21351
See related
Ensembl:ENSG00000197261 AllianceGenome:HGNC:21351
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in blastocyst hatching. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in gall bladder (RPKM 5.1), duodenum (RPKM 3.8) and 17 other tissues See more
Orthologs
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Genomic context

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See C6orf141 in Genome Data Viewer
Location:
6p12.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (49550668..49561916)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (49392796..49404015)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (49518381..49529629)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:49431050-49431949 Neighboring gene centromere protein Q Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:49450846-49451350 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:49451351-49451854 Neighboring gene glycine-N-acyltransferase like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24664 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:49519182-49519701 Neighboring gene Sharpr-MPRA regulatory region 6456 Neighboring gene cytochrome P450 family 2 subfamily AC member 1, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr6:49553494-49553995 Neighboring gene MPRA-validated peak5837 silencer Neighboring gene Rh associated glycoprotein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Low C6orf141 Expression is Significantly Associated with a Poor Prognosis in Patients with Oral Cancer. Yang CM, et al. Sci Rep, 2019 Mar 14. PMID 30872783, Free PMC Article
  2. Phospho-tyrosine dependent protein-protein interaction network. Grossmann A, et al. Mol Syst Biol, 2015 Mar 26. PMID 25814554, Free PMC Article
  3. The DNA sequence and analysis of human chromosome 6. Mungall AJ, et al. Nature, 2003 Oct 23. PMID 14574404
  4. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Low C6orf141 Expression is Significantly Associated with a Poor Prognosis in Patients with Oral Cancer.
    Title: Low C6orf141 Expression is Significantly Associated with a Poor Prognosis in Patients with Oral Cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC46457

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein C6orf141

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145652.2 → NP_001139124.2  uncharacterized protein C6orf141

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AL590244
    Consensus CDS
    CCDS55018.1
    UniProtKB/Swiss-Prot
    A8K1H4, Q5SZD1, Q8N400, Q96NQ1
    Related
    ENSP00000434602.2, ENST00000529246.4

RNA

  1. NR_146853.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  2. NR_146854.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  3. NR_146855.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  4. NR_146856.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  5. NR_146857.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  6. NR_146858.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  7. NR_146859.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  8. NR_146860.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  9. NR_146861.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  10. NR_146862.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  11. NR_146863.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  12. NR_146864.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  13. NR_170563.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  14. NR_170564.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  15. NR_170565.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  16. NR_170566.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  17. NR_170567.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  18. NR_170568.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  19. NR_170569.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  20. NR_170570.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  21. NR_170571.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  22. NR_170572.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  23. NR_170573.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  24. NR_170574.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  25. NR_170575.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  26. NR_170576.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  27. NR_170577.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  28. NR_170578.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  29. NR_170579.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  30. NR_170580.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  31. NR_170581.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  32. NR_170582.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  33. NR_170583.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  34. NR_170584.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  35. NR_170585.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  36. NR_170586.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  37. NR_170587.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  38. NR_170588.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  39. NR_170589.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  40. NR_170590.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  41. NR_170591.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  42. NR_170592.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

  43. NR_170593.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590244

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    49550668..49561916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418229.1 → XP_047274185.1  uncharacterized protein C6orf141 isoform X1

    UniProtKB/Swiss-Prot
    A8K1H4, Q5SZD1, Q8N400, Q96NQ1

  2. XM_047418226.1 → XP_047274182.1  uncharacterized protein C6orf141 isoform X1

    UniProtKB/Swiss-Prot
    A8K1H4, Q5SZD1, Q8N400, Q96NQ1

  3. XM_047418230.1 → XP_047274186.1  uncharacterized protein C6orf141 isoform X1

    UniProtKB/Swiss-Prot
    A8K1H4, Q5SZD1, Q8N400, Q96NQ1
    Related
    ENSP00000436754.1, ENST00000414696.5

  4. XM_047418225.1 → XP_047274181.1  uncharacterized protein C6orf141 isoform X1

    UniProtKB/Swiss-Prot
    A8K1H4, Q5SZD1, Q8N400, Q96NQ1

  5. XM_005248850.4 → XP_005248907.1  uncharacterized protein C6orf141 isoform X1

    See identical proteins and their annotated locations for XP_005248907.1

    UniProtKB/Swiss-Prot
    A8K1H4, Q5SZD1, Q8N400, Q96NQ1

  6. XM_047418227.1 → XP_047274183.1  uncharacterized protein C6orf141 isoform X1

    UniProtKB/Swiss-Prot
    A8K1H4, Q5SZD1, Q8N400, Q96NQ1

  7. XM_047418231.1 → XP_047274187.1  uncharacterized protein C6orf141 isoform X1

    UniProtKB/Swiss-Prot
    A8K1H4, Q5SZD1, Q8N400, Q96NQ1

  8. XM_006714997.3 → XP_006715060.1  uncharacterized protein C6orf141 isoform X1

    See identical proteins and their annotated locations for XP_006715060.1

    UniProtKB/Swiss-Prot
    A8K1H4, Q5SZD1, Q8N400, Q96NQ1

  9. XM_047418228.1 → XP_047274184.1  uncharacterized protein C6orf141 isoform X1

    UniProtKB/Swiss-Prot
    A8K1H4, Q5SZD1, Q8N400, Q96NQ1
    Related
    ENSP00000431184.1, ENST00000371194.7

  10. XM_005248853.3 → XP_005248910.1  uncharacterized protein C6orf141 isoform X1

    See identical proteins and their annotated locations for XP_005248910.1

    UniProtKB/Swiss-Prot
    A8K1H4, Q5SZD1, Q8N400, Q96NQ1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    49392796..49404015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354322.1 → XP_054210297.1  uncharacterized protein C6orf141 isoform X1

  2. XM_054354324.1 → XP_054210299.1  uncharacterized protein C6orf141 isoform X1

  3. XM_054354327.1 → XP_054210302.1  uncharacterized protein C6orf141 isoform X1

  4. XM_054354321.1 → XP_054210296.1  uncharacterized protein C6orf141 isoform X1

  5. XM_054354319.1 → XP_054210294.1  uncharacterized protein C6orf141 isoform X1

  6. XM_054354326.1 → XP_054210301.1  uncharacterized protein C6orf141 isoform X1

  7. XM_054354325.1 → XP_054210300.1  uncharacterized protein C6orf141 isoform X1

  8. XM_054354318.1 → XP_054210293.1  uncharacterized protein C6orf141 isoform X1

  9. XM_054354316.1 → XP_054210291.1  uncharacterized protein C6orf141 isoform X1

  10. XM_054354317.1 → XP_054210292.1  uncharacterized protein C6orf141 isoform X1

  11. XM_054354320.1 → XP_054210295.1  uncharacterized protein C6orf141 isoform X1

  12. XM_054354323.1 → XP_054210298.1  uncharacterized protein C6orf141 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153344.1: Suppressed sequence

    Description
    NM_153344.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SZD1.3 GenPept UniProtKB/Swiss-Prot:Q5SZD1

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