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Drp2 dystrophin related protein 2 [ Mus musculus (house mouse) ]

Gene ID: 13497, updated on 6-Jun-2024

Summary

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Official Symbol
Drp2provided by MGI
Official Full Name
dystrophin related protein 2provided by MGI
Primary source
MGI:MGI:107432
See related
Ensembl:ENSMUSG00000000223 AllianceGenome:MGI:107432
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DRP-2
Summary
Predicted to enable zinc ion binding activity. Predicted to be involved in synapse organization and synaptic signaling. Located in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and hemolymphoid system gland. Orthologous to human DRP2 (dystrophin related protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 10.1), cortex adult (RPKM 10.1) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Drp2 in Genome Data Viewer
Location:
X E3; X 56.18 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (133304868..133357323)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (134404124..134456574)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene transmembrane protein 35A Neighboring gene centromere protein I Neighboring gene STARR-seq mESC enhancer starr_47958 Neighboring gene STARR-seq mESC enhancer starr_47959 Neighboring gene TATA-box binding protein associated factor 7 like Neighboring gene STAT3-interacting protein as a repressor pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of DRP2, a novel human dystrophin homologue. Roberts RG, et al. Nat Genet, 1996 Jun. PMID 8640231
  2. Drp2 and periaxin form Cajal bands with dystroglycan but have distinct roles in Schwann cell growth. Sherman DL, et al. J Neurosci, 2012 Jul 4. PMID 22764250, Free PMC Article
  3. Expression of the dystrophin-related protein 2 (Drp2) transcript in the mouse. Dixon AK, et al. J Mol Biol, 1997 Jul 25. PMID 9245586
  4. gamma-Syntrophin scaffolding is spatially and functionally distinct from that of the alpha/beta syntrophins. Alessi A, et al. Exp Cell Res, 2006 Oct 1. PMID 16857187
  5. Specific disruption of a schwann cell dystrophin-related protein complex in a demyelinating neuropathy. Sherman DL, et al. Neuron, 2001 Jun. PMID 11430802

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cajal band appositions contain a dystroglycan complex that includes periaxin and dystrophin-related protein (Drp)2.
    Title: Drp2 and periaxin form Cajal bands with dystroglycan but have distinct roles in Schwann cell growth.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC159048, MGC159050

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in synapse organization ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dystrophin-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411867.1 → NP_001398796.1  dystrophin-related protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672064
    UniProtKB/TrEMBL
    Q3TZ53

  2. NM_001411868.1 → NP_001398797.1  dystrophin-related protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672064
    UniProtKB/TrEMBL
    B1AV35, Q3TZ53
    Related
    ENSMUSP00000108850.3, ENSMUST00000113224.9

  3. NM_001411869.1 → NP_001398798.1  dystrophin-related protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL672064
    UniProtKB/Swiss-Prot
    Q05AA6, Q61095, Q8C4R1
    UniProtKB/TrEMBL
    Q3TZ53

  4. NM_001411870.1 → NP_001398799.1  dystrophin-related protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL672064
    UniProtKB/Swiss-Prot
    Q05AA6, Q61095, Q8C4R1
    UniProtKB/TrEMBL
    Q3TZ53

  5. NM_001411871.1 → NP_001398800.1  dystrophin-related protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL672064
    UniProtKB/TrEMBL
    Q3TZ53

  6. NM_001411872.1 → NP_001398801.1  dystrophin-related protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL672064
    UniProtKB/Swiss-Prot
    Q05AA6, Q61095, Q8C4R1
    UniProtKB/TrEMBL
    Q3TZ53

  7. NM_010078.4 → NP_034208.2  dystrophin-related protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL672064
    Consensus CDS
    CCDS30394.1
    UniProtKB/Swiss-Prot
    Q05AA6, Q61095, Q8C4R1
    UniProtKB/TrEMBL
    Q3TZ53
    Related
    ENSMUSP00000115246.2, ENSMUST00000153424.8
    Conserved Domains (4) summary
    cd00176
    Location:111 → 339
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd00201
    Location:357 → 385
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd02334
    Location:608 → 656
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16248
    Location:422 → 583
    EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    133304868..133357323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251218.2 → XP_030107078.1  dystrophin-related protein 2 isoform X5

    UniProtKB/TrEMBL
    Q3TZ53
    Conserved Domains (4) summary
    cd00176
    Location:84 → 194
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd00201
    Location:209 → 237
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd02334
    Location:460 → 508
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16248
    Location:274 → 435
    EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

  2. XM_036161807.1 → XP_036017700.1  dystrophin-related protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q05AA6, Q61095, Q8C4R1
    UniProtKB/TrEMBL
    Q3TZ53
    Related
    ENSMUSP00000108854.2, ENSMUST00000113228.8
    Conserved Domains (4) summary
    cd00176
    Location:111 → 339
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd00201
    Location:357 → 385
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd02334
    Location:608 → 656
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16248
    Location:422 → 583
    EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

  3. XM_011247730.1 → XP_011246032.1  dystrophin-related protein 2 isoform X1

    UniProtKB/TrEMBL
    Q3TZ53
    Conserved Domains (4) summary
    cd00176
    Location:33 → 261
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd00201
    Location:279 → 307
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd02334
    Location:515 → 563
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16248
    Location:344 → 490
    EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

  4. XM_030251220.1 → XP_030107080.1  dystrophin-related protein 2 isoform X5

    UniProtKB/TrEMBL
    Q3TZ53
    Conserved Domains (4) summary
    cd00176
    Location:84 → 194
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd00201
    Location:209 → 237
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd02334
    Location:460 → 508
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16248
    Location:274 → 435
    EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

RNA

  1. XR_003952997.2 RNA Sequence

  2. XR_001782733.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05AA6.1 GenPept UniProtKB/Swiss-Prot:Q05AA6

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