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Dok1 docking protein 1 [ Mus musculus (house mouse) ]

Gene ID: 13448, updated on 14-Nov-2024

Summary

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Official Symbol
Dok1provided by MGI
Official Full Name
docking protein 1provided by MGI
Primary source
MGI:MGI:893587
See related
Ensembl:ENSMUSG00000068335 AllianceGenome:MGI:893587
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p62DOK
Summary
Acts upstream of or within Ras protein signal transduction; cell surface receptor protein tyrosine kinase signaling pathway; and macrophage colony-stimulating factor signaling pathway. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human DOK1 (docking protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E14.5 (RPKM 9.9), spleen adult (RPKM 9.8) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Dok1 in Genome Data Viewer
Location:
6 C3; 6 35.94 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83007915..83010448, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83030932..83033495, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene meiosis 1 associated protein Neighboring gene predicted gene, 53290 Neighboring gene predicted gene, 32644 Neighboring gene STARR-seq mESC enhancer starr_16455 Neighboring gene STARR-positive B cell enhancer ABC_E2791 Neighboring gene lysyl oxidase-like 3 Neighboring gene STARR-positive B cell enhancer ABC_E9275 Neighboring gene microRNA 7040 Neighboring gene HtrA serine peptidase 2 Neighboring gene ancient ubiquitous protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells. Tamir I, et al. Immunity, 2000 Mar. PMID 10755621
  2. Expression, crystallization and preliminary X-ray studies of the recombinant PTB domain of mouse dok1 protein. Shi N, et al. Acta Crystallogr D Biol Crystallogr, 2004 Feb. PMID 14747716
  3. Dok-1 tyrosine residues at 336 and 340 are essential for the negative regulation of Ras-Erk signalling, but dispensable for rasGAP-binding. Shinohara H, et al. Genes Cells, 2004 Jun. PMID 15189452
  4. A nuclear export signal and phosphorylation regulate Dok1 subcellular localization and functions. Niu Y, et al. Mol Cell Biol, 2006 Jun. PMID 16705178, Free PMC Article
  5. Downstream of tyrosine kinases-1 and Src homology 2-containing inositol 5'-phosphatase are required for regulation of CD4+CD25+ T cell development. Kashiwada M, et al. J Immunol, 2006 Apr 1. PMID 16547230

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DOK1 and DOK2 regulate CD8 T cell signaling and memory formation without affecting tumor cell killing.
    Title: DOK1 and DOK2 regulate CD8 T cell signaling and memory formation without affecting tumor cell killing.
  2. findings demonstrate that Dok-3 and Dok-1/-2 play distinctive but cooperative roles in osteoclastogenesis and protect mice from osteopenia, providing physiological and pathophysiological insight into bone homeostasis.
    Title: Dok-3 and Dok-1/-2 adaptors play distinctive roles in cell fusion and proliferation during osteoclastogenesis and cooperatively protect mice from osteopenia.
  3. Platelets from Dok-1-/- mice displayed normal aggregation, activation of integrin alphaIIbbeta3, P-selectin surface expression, and soluble fibrinogen binding. These findings indicate that Dok-1 does not affect "inside-out" platelet signalling.
    Title: Dok-1 negatively regulates platelet integrin αIIbβ3 outside-in signalling and inhibits thrombosis in mice.
  4. in the absence of PAG, Csk becomes more associated with alternative partners; i.e., phosphatase PTPN22 and Dok adaptors. Combining PAG deficiency with PTPN22 or Dok adaptor deficiency further enhances effector T cell responses. Unlike PAG, Cbl ubiquitin ligases inhibit the activation of naive, but not of effector, T cells.
    Title: The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors.
  5. These results reveal the critical involvement of Dok-1 and Dok-2 in a negative-feedback loop that prevents overactivation of CD8(+) T cells and promotes memory formation.
    Title: Dok-1 and Dok-2 Regulate the Formation of Memory CD8+ T Cells.
  6. Thus, Dok-1 and Dok-2 promote survival of glycoprotein B-specific CD8(+) T cells in trigeminal ganglia latently infected with herpes simplex virus 1.
    Title: Dok-1 and Dok-2 Are Required To Maintain Herpes Simplex Virus 1-Specific CD8(+) T Cells in a Murine Model of Ocular Infection.
  7. this study shows that Dok1 and Dok2 proteins are involved in the control of hematopoietic stem cell cycle regulation
    Title: Dok1 and Dok2 Proteins Regulate Cell Cycle in Hematopoietic Stem and Progenitor Cells.
  8. Taken together, our results demonstrate that Dok-1 and Dok-2 negatively regulate intestinal inflammation, apparently through the induction of IL-17A and IL-22 expression.
    Title: Loss of Dok-1 and Dok-2 in mice causes severe experimental colitis accompanied by reduced expression of IL-17A and IL-22.
  9. Dok1 knockdown attenuated TLR2-induced NF-kappaB activation and IL-6 production in microglia.
    Title: Differential role of Dok1 and Dok2 in TLR2-induced inflammatory signaling in glia.
  10. Triple Dok1 Doc2 Doc3 knockout leads to spontaneous pulmonary inflammation with hallmarks of asthma.
    Title: Dok adaptors play anti-inflammatory roles in pulmonary homeostasis.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Ras protein signal transduction IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within intracellular signal transduction IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within macrophage colony-stimulating factor signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of MAPK cascade TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
docking protein 1
Names
downstream of tyrosine kinase 1
p62(dok)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409625.1 → NP_001396554.1  docking protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC104324, AC158652

  2. NM_001409626.1 → NP_001396555.1  docking protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC104324, AC158652

  3. NM_010070.5 → NP_034200.4  docking protein 1 isoform 1

    See identical proteins and their annotated locations for NP_034200.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC104324, AC158652
    Consensus CDS
    CCDS20265.1
    UniProtKB/Swiss-Prot
    P97465, Q9R213
    UniProtKB/TrEMBL
    Q3UWF9
    Related
    ENSMUSP00000087079.6, ENSMUST00000089651.6
    Conserved Domains (3) summary
    cd01203
    Location:151 → 253
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    pfam00169
    Location:5 → 116
    PH; PH domain
    cl17171
    Location:6 → 119
    PH-like; Pleckstrin homology-like domain

RNA

  1. NR_176878.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104324, AC158652
    Related
    ENSMUST00000149918.2

  2. NR_176879.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104324, AC158652

  3. NR_176880.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104324, AC158652

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    83007915..83010448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97465.2 GenPept UniProtKB/Swiss-Prot:P97465

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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