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Dcn decorin [ Mus musculus (house mouse) ]

Gene ID: 13179, updated on 2-Nov-2024

Summary

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Official Symbol
Dcnprovided by MGI
Official Full Name
decorinprovided by MGI
Primary source
MGI:MGI:94872
See related
Ensembl:ENSMUSG00000019929 AllianceGenome:MGI:94872
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DC; PG40; PGII; PGS2; DSPG2; SLRR1B
Summary
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate a mature protein product, which is secreted into the extracellular space to regulate collagen fibril assembly. Homozygous knockout mice for this gene exhibit enhanced tumorigenesis in a liver cancer model, and defects in collagen fibrils, leading to weakened skin and tendons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Expression
Biased expression in bladder adult (RPKM 1095.0), subcutaneous fat pad adult (RPKM 305.9) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Dcn in Genome Data Viewer
Location:
10 C3; 10 50.27 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (97315362..97354025)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (97479500..97518163)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene CWC15 homolog pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8867 Neighboring gene STARR-seq mESC enhancer starr_27689 Neighboring gene STARR-positive B cell enhancer ABC_E6912 Neighboring gene predicted gene, 34114 Neighboring gene microRNA 3966 Neighboring gene STARR-seq mESC enhancer starr_27690 Neighboring gene STARR-seq mESC enhancer starr_27691 Neighboring gene RIKEN cDNA 4930473O22 gene Neighboring gene lumican

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Decorin modulates collagen matrix assembly and mineralization. Mochida Y, et al. Matrix Biol, 2009 Jan. PMID 19049867, Free PMC Article
  2. Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation. Bi X, et al. Carcinogenesis, 2008 Jul. PMID 18550571, Free PMC Article
  3. Decorin deficiency promotes hepatic carcinogenesis. Horváth Z, et al. Matrix Biol, 2014 Apr. PMID 24361483, Free PMC Article
  4. Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction. Schaefer L, et al. Am J Pathol, 2002 Mar. PMID 11891213, Free PMC Article
  5. Pathophysiological mechanisms of autosomal dominant congenital stromal corneal dystrophy: C-terminal-truncated decorin results in abnormal matrix assembly and altered expression of small leucine-rich proteoglycans. Chen S, et al. Am J Pathol, 2011 Nov. PMID 21893019, Free PMC Article

See all (231) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Decorin in the spatial control of collagen mineralization.
    Title: Decorin in the spatial control of collagen mineralization.
  2. A role for decorin in improving motor deficits after traumatic brain injury.
    Title: A role for decorin in improving motor deficits after traumatic brain injury.
  3. Neonatal Achilles Tendon Microstructure is Negatively Impacted by Decorin and Biglycan Knockdown After Injury and During Development.
    Title: Neonatal Achilles Tendon Microstructure is Negatively Impacted by Decorin and Biglycan Knockdown After Injury and During Development.
  4. Investigating the temporal roles of decorin and biglycan in tendon healing.
    Title: Investigating the temporal roles of decorin and biglycan in tendon healing.
  5. The aberrant levels of decorin induce damages of human salivary gland epithelial cells and polarization of macrophages.
    Title: The aberrant levels of decorin induce damages of human salivary gland epithelial cells and polarization of macrophages.
  6. [Effect of up-regulation of Decorin on expression of EGFR, C-Myc and p21 in nude mice with oral squamous cell carcinoma].
    Title: [Effect of up-regulation of Decorin on expression of EGFR, C-Myc and p21 in nude mice with oral squamous cell carcinoma].
  7. Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss.
    Title: Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss.
  8. Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's Abeta amyloidosis.
    Title: Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's Aβ amyloidosis.
  9. Decorin Induces Cardiac Hypertrophy by Regulating the CaMKII/MEF-2 Signaling Pathway In Vivo.
    Title: Decorin Induces Cardiac Hypertrophy by Regulating the CaMKII/MEF-2 Signaling Pathway In Vivo.
  10. Transcriptomic profiling of fetal membranes of mice deficient in biglycan and decorin as a model of preterm birthdagger.
    Title: Transcriptomic profiling of fetal membranes of mice deficient in biglycan and decorin as a model of preterm birth†.
Submit: New GeneRIF Correction See all GeneRIFs (92)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding ISO
Inferred from Sequence Orthology
more info
  
enables extracellular matrix binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables extracellular matrix structural constituent conferring compression resistance RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables glycosaminoglycan binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of collagen type VI trimer ISO
Inferred from Sequence Orthology
more info
  
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
decorin
Names
bone proteoglycan II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190451.2 → NP_001177380.1  decorin preproprotein

    See identical proteins and their annotated locations for NP_001177380.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC159710, AK145905, BG088078, BM114383
    Consensus CDS
    CCDS24141.1
    UniProtKB/Swiss-Prot
    P28654
    UniProtKB/TrEMBL
    Q3TSV1, Q3UKR1
    Related
    ENSMUSP00000100924.4, ENSMUST00000105287.11
    Conserved Domains (4) summary
    smart00013
    Location:48 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:79 → 285
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:57 → 77
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:79 → 136
    LRR_8; Leucine rich repeat

  2. NM_007833.6 → NP_031859.1  decorin preproprotein

    See identical proteins and their annotated locations for NP_031859.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA881173, AC159710, BB575065, BM114383, CK623125, DV056002, W62675
    Consensus CDS
    CCDS24141.1
    UniProtKB/Swiss-Prot
    P28654
    UniProtKB/TrEMBL
    Q3TSV1, Q3UKR1
    Related
    ENSMUSP00000131431.3, ENSMUST00000163448.4
    Conserved Domains (4) summary
    smart00013
    Location:48 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:79 → 285
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:57 → 77
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:79 → 136
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    97315362..97354025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28654.1 GenPept UniProtKB/Swiss-Prot:P28654

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