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LYZL4 lysozyme like 4 [ Homo sapiens (human) ]

Gene ID: 131375, updated on 2-Nov-2024

Summary

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Official Symbol
LYZL4provided by HGNC
Official Full Name
lysozyme like 4provided by HGNC
Primary source
HGNC:HGNC:28387
See related
Ensembl:ENSG00000157093 MIM:612750; AllianceGenome:HGNC:28387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LYC4; LYZA
Summary
Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL4 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr 2009]
Expression
Restricted expression toward testis (RPKM 6.7) See more
Orthologs
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Genomic context

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See LYZL4 in Genome Data Viewer
Location:
3p22.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (42360764..42410610, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (42378784..42445904, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (42438575..42452102, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene spalt like transcription factor 4 pseudogene 6 Neighboring gene eukaryotic translation initiation factor 4B pseudogene 4 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:42411131-42411759 Neighboring gene NANOG hESC enhancer GRCh37_chr3:42426849-42427356 Neighboring gene uncharacterized LOC124909371 Neighboring gene ribosomal protein L35a pseudogene 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19745 Neighboring gene uncharacterized LOC124909372 Neighboring gene vasoactive intestinal peptide receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family. Zhang K, et al. Biol Reprod, 2005 Nov. PMID 16014814
  2. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. McClay JL, et al. Neuropsychopharmacology, 2011 Feb. PMID 21107309, Free PMC Article
  3. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. Chen Y, et al. Mol Cell Proteomics, 2013 Oct. PMID 23824909, Free PMC Article
  4. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC26768, 1810009N24Rik

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lysozyme activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
NOT involved_in defense response to bacterium ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fertilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus HDA PubMed 
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
lysozyme-like protein 4
Names
lysozyme A
lysozyme-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304386.2 → NP_001291315.1  lysozyme-like protein 4 precursor

    See identical proteins and their annotated locations for NP_001291315.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC092048, BC016747, BX282166, HY037577
    Consensus CDS
    CCDS2697.1
    UniProtKB/Swiss-Prot
    Q96KX0
    UniProtKB/TrEMBL
    A0A080YUZ5
    Related
    ENSP00000387897.1, ENST00000441172.1
    Conserved Domains (1) summary
    cd16897
    Location:21 → 144
    LYZ_C; C-type lysozyme

  2. NM_144634.4 → NP_653235.1  lysozyme-like protein 4 precursor

    See identical proteins and their annotated locations for NP_653235.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC092048, BC016747, HY037577
    Consensus CDS
    CCDS2697.1
    UniProtKB/Swiss-Prot
    Q96KX0
    UniProtKB/TrEMBL
    A0A080YUZ5
    Related
    ENSP00000287748.3, ENST00000287748.8
    Conserved Domains (1) summary
    cd16897
    Location:21 → 144
    LYZ_C; C-type lysozyme

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    42360764..42410610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533355.4 → XP_011531657.1  lysozyme-like protein 4 isoform X1

    Conserved Domains (1) summary
    cd00119
    Location:20 → 123
    LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    42378784..42445904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345215.1 → XP_054201190.1  lysozyme-like protein 4 isoform X1

  2. XM_054345216.1 → XP_054201191.1  lysozyme-like protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q96KX0
    UniProtKB/TrEMBL
    A0A080YUZ5

  3. XM_054345214.1 → XP_054201189.1  lysozyme-like protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q96KX0
    UniProtKB/TrEMBL
    A0A080YUZ5

  4. XM_054345213.1 → XP_054201188.1  lysozyme-like protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q96KX0
    UniProtKB/TrEMBL
    A0A080YUZ5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96KX0.1 GenPept UniProtKB/Swiss-Prot:Q96KX0

Gene LinkOut

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