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Cyp2j6 cytochrome P450, family 2, subfamily j, polypeptide 6 [ Mus musculus (house mouse) ]

Gene ID: 13110, updated on 2-Nov-2024

Summary

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Official Symbol
Cyp2j6provided by MGI
Official Full Name
cytochrome P450, family 2, subfamily j, polypeptide 6provided by MGI
Primary source
MGI:MGI:1270148
See related
Ensembl:ENSMUSG00000052914 AllianceGenome:MGI:1270148
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables arachidonate epoxygenase activity. Predicted to be involved in several processes, including negative regulation of collagen biosynthetic process; positive regulation of biosynthetic process; and unsaturated fatty acid metabolic process. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; integumental system; metanephros; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypertension (multiple); myocardial infarction; and renal fibrosis. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in duodenum adult (RPKM 4.6), large intestine adult (RPKM 2.5) and 22 other tissues See more
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Genomic context

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See Cyp2j6 in Genome Data Viewer
Location:
4 C5; 4 44.62 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (96404375..96449835, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (96516138..96564305, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily j, member 14, pseudogene Neighboring gene STARR-seq mESC enhancer starr_10825 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 8 Neighboring gene STARR-seq mESC enhancer starr_10826 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 9 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of mouse CYP2J6, an unstable cytochrome P450 isoform. Ma J, et al. Biochem Pharmacol, 2002 Nov 15. PMID 12417258
  2. Molecular cloning, enzymatic characterization, developmental expression, and cellular localization of a mouse cytochrome P450 highly expressed in kidney. Ma J, et al. J Biol Chem, 1999 Jun 18. PMID 10364221
  3. Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain. Sisignano M, et al. Proc Natl Acad Sci U S A, 2016 Nov 1. PMID 27791151, Free PMC Article
  4. Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway. Seubert J, et al. Circ Res, 2004 Sep 3. PMID 15256482
  5. Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase. Nayeem MA, et al. Am J Physiol Regul Integr Comp Physiol, 2010 Jul. PMID 20427718, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADPH-hemoprotein reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonate 11,12-epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonate 14,15-epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonate epoxygenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables arachidonate epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonate monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables linoleic acid epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in arachidonate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in epoxygenase P450 pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in icosanoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in linoleic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of peroxisome proliferator activated receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in retinoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytochrome P450 2J6
Names
CYPIIJ6
arachidonic acid epoxygenase
cytochrome P450, 2j6
NP_001407757.1
NP_034138.3
XP_006502785.1
XP_030109023.1
XP_036019523.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420828.1 → NP_001407757.1  cytochrome P450 2J6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL683816

  2. NM_010008.5 → NP_034138.3  cytochrome P450 2J6 isoform 1

    See identical proteins and their annotated locations for NP_034138.3

    Status: VALIDATED

    Source sequence(s)
    AL683816
    Consensus CDS
    CCDS18369.1
    UniProtKB/Swiss-Prot
    O54750, Q8BR78
    UniProtKB/TrEMBL
    Q8CC91
    Related
    ENSMUSP00000030303.5, ENSMUST00000030303.6
    Conserved Domains (1) summary
    pfam00067
    Location:44 → 496
    p450; Cytochrome P450

RNA

  1. NR_185201.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL683816

  2. NR_185202.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL683816

  3. NR_185203.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL683816

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    96404375..96449835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502722.5 → XP_006502785.1  cytochrome P450 2J6 isoform X4

    Conserved Domains (1) summary
    cl41757
    Location:1 → 259
    cytochrome_P450; cytochrome P450 (CYP) superfamily

  2. XM_036163630.1 → XP_036019523.1  cytochrome P450 2J6 isoform X4

    Conserved Domains (1) summary
    cl41757
    Location:1 → 259
    cytochrome_P450; cytochrome P450 (CYP) superfamily

  3. XM_030253163.2 → XP_030109023.1  cytochrome P450 2J6 isoform X5

    Conserved Domains (1) summary
    cl12078
    Location:44 → 229
    p450; Cytochrome P450
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54750.2 GenPept UniProtKB/Swiss-Prot:O54750

Gene LinkOut

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