Ctsw cathepsin W [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctswprovided by MGI
Official Full Name: cathepsin Wprovided by MGI
Primary source: MGI:MGI:1338045
See related: Ensembl:ENSMUSG00000024910 AllianceGenome:MGI:1338045
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: lymphopain
Summary: This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate a mature protein product. Expression of the encoded protein is upregulated following lymphocyte activation. Data from a human cell line suggests that the encoded enzyme may be important for viral entry into host cells. [provided by RefSeq, Aug 2015]
Expression: Biased expression in thymus adult (RPKM 6.4), spleen adult (RPKM 5.8) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.33 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (5515071..5518558, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (5465043..5468628, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proteomic Identification of Potential Target Proteins of Cathepsin W for Its Development as a Drug Target for Influenza.
Title: Proteomic Identification of Potential Target Proteins of Cathepsin W for Its Development as a Drug Target for Influenza.
mCtsW does not have a unique role in target cell apoptosis or cytotoxic cell survival in vitro.
Title: Characterization of murine cathepsin W and its role in cell-mediated cytotoxicity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cathepsin W

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009985.5 → NP_034115.2 cathepsin W preproprotein

See identical proteins and their annotated locations for NP_034115.2

Status: REVIEWED

Source sequence(s)

AC122861, BB850740, BE447240

Consensus CDS

CCDS29465.1

UniProtKB/Swiss-Prot

P56203

UniProtKB/TrEMBL

A0A494BA69, Q8C2M0

Related

ENSMUSP00000025844.5, ENSMUST00000025844.6

Conserved Domains (2) summary

smart00848
Location:40 → 96

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

pfam00112
Location:126 → 356

Peptidase_C1; Papain family cysteine protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

5515071..5518558 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006531661.5 → XP_006531724.1 cathepsin W isoform X1

Conserved Domains (2) summary

PTZ00203
Location:39 → 204

PTZ00203; cathepsin L protease; Provisional

cl23744
Location:126 → 204

Peptidase_C1; C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some ...