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LOC129999962 ATAC-STARR-seq lymphoblastoid silent region 18973 [ Homo sapiens (human) ]

Gene ID: 129999962, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129999962
Gene description
ATAC-STARR-seq lymphoblastoid silent region 18973
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region that was validated as a silencer based on its ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC129999962 in Genome Data Viewer
Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (21897472..21897531)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (22171455..22171514)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (21754983..21755042)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986922 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:21507398-21507984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21550331-21550831 Neighboring gene GDNF family receptor alpha 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:21584471-21584972 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_102784 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_102790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21625596-21626586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:21639775-21640276 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:21683545-21684088 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:21683000-21683544 Neighboring gene olfactory receptor family 6 subfamily R member 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27067 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21761370-21762198 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27069 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18974 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:21802075-21802708 Neighboring gene uncharacterized LOC124901903 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21806752-21807252 Neighboring gene docking protein 2 Neighboring gene exportin 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_179408.1 

    Range
    101..160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    21897472..21897531
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    22171455..22171514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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