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Csn3 casein kappa [ Mus musculus (house mouse) ]

Gene ID: 12994, updated on 17-Aug-2024

Summary

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Official Symbol
Csn3provided by MGI
Official Full Name
casein kappaprovided by MGI
Primary source
MGI:MGI:107461
See related
Ensembl:ENSMUSG00000001622 AllianceGenome:MGI:107461
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Csnk; CSN10
Summary
Acts upstream of or within lactation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in central nervous system and retina. Orthologous to human CSN3 (casein kappa). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward mammary gland adult (RPKM 13.7) See more
Orthologs
human all
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Genomic context

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See Csn3 in Genome Data Viewer
Location:
5 E1; 5 43.56 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (88073438..88080409)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (87925579..87932550)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene odontogenic, ameloblast asssociated Neighboring gene RIKEN cDNA 1700066N21 gene Neighboring gene cDNA sequence BC037156 Neighboring gene cDNA sequence BC051076 Neighboring gene STARR-seq mESC enhancer starr_13565 Neighboring gene calcium binding protein, spermatid specific 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning of mouse mammary gland kappa-casein: comparison with rat kappa-casein and rat and human gamma-fibrinogen. Thompson MD, et al. DNA, 1985 Aug. PMID 4042811
  2. Thrombin-Par1 signaling axis disrupts COP9 signalosome subunit 3-mediated ABCA1 stabilization in inducing foam cell formation and atherogenesis. Boro M, et al. Cell Death Differ, 2021 Feb. PMID 32968199, Free PMC Article
  3. Evidence from milk casein genes that cetaceans are close relatives of hippopotamid artiodactyls. Gatesy J, et al. Mol Biol Evol, 1996 Sep. PMID 8752004
  4. Csn3 gene is regulated by all-trans retinoic acid during neural differentiation in mouse P19 cells. Komori R, et al. PLoS One, 2013. PMID 23613978, Free PMC Article
  5. Expression analysis of the individual bovine beta-, alpha s2- and kappa-casein genes in transgenic mice. Rijnkels M, et al. Biochem J, 1995 Nov 1. PMID 7487953, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thrombin-Par1 signaling axis disrupts COP9 signalosome subunit 3-mediated ABCA1 stabilization in inducing foam cell formation and atherogenesis.
    Title: Thrombin-Par1 signaling axis disrupts COP9 signalosome subunit 3-mediated ABCA1 stabilization in inducing foam cell formation and atherogenesis.
  2. the Csn3 expression is upregulated via all-trans retinoic acid-bound RARalpha.
    Title: Csn3 gene is regulated by all-trans retinoic acid during neural differentiation in mouse P19 cells.
  3. CSN3 and CSN5 are involved in oocyte meiosis by regulating degradation of Cyclin B1 and Securin via APC/C.
    Title: Function of COP9 signalosome in regulation of mouse oocytes meiosis by regulating MPF activity and securing degradation.
  4. kappa-casein has a role in mouse lactation
    Title: kappa-casein-deficient mice fail to lactate.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in lactation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lactation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lactation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kappa-casein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356570.1 → NP_001343499.1  kappa-casein isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC022298, AK164788
    Consensus CDS
    CCDS19396.1
    UniProtKB/Swiss-Prot
    P06796, Q9D1U2
    Related
    ENSMUSP00000001667.7, ENSMUST00000001667.13
    Conserved Domains (1) summary
    pfam00997
    Location:22 → 180
    Casein_kappa; Kappa casein

  2. NM_001356571.1 → NP_001343500.1  kappa-casein isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC022298
    Conserved Domains (1) summary
    pfam00997
    Location:20 → 170
    Casein_kappa; Kappa casein

  3. NM_007786.5 → NP_031812.2  kappa-casein isoform a precursor

    See identical proteins and their annotated locations for NP_031812.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC022298, AK142673
    Consensus CDS
    CCDS19396.1
    UniProtKB/Swiss-Prot
    P06796, Q9D1U2
    Related
    ENSMUSP00000108896.3, ENSMUST00000113271.3
    Conserved Domains (1) summary
    pfam00997
    Location:22 → 180
    Casein_kappa; Kappa casein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    88073438..88080409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06796.2 GenPept UniProtKB/Swiss-Prot:P06796

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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