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Cr1l complement C3b/C4b receptor 1 like [ Mus musculus (house mouse) ]

Gene ID: 12946, updated on 2-Nov-2024

Summary

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Official Symbol
Cr1lprovided by MGI
Official Full Name
complement C3b/C4b receptor 1 likeprovided by MGI
Primary source
MGI:MGI:88513
See related
Ensembl:ENSMUSG00000016481 AllianceGenome:MGI:88513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mcp; Crry; mCRY
Summary
Predicted to enable complement receptor activity and opsonin binding activity. Acts upstream of or within several processes, including cellular response to hypoxia; complement activation; and negative regulation of complement activation. Located in basolateral plasma membrane and external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Human ortholog(s) of this gene implicated in malaria. Orthologous to several human genes including CR1L (complement C3b/C4b receptor 1 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 23.9), placenta adult (RPKM 23.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cr1l in Genome Data Viewer
Location:
1 H6; 1 98.43 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (194781019..194813878, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (195098711..195131570, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A330023F24 gene Neighboring gene microRNA 29b-2 Neighboring gene STARR-seq mESC enhancer starr_03503 Neighboring gene microRNA 29c Neighboring gene CD46 antigen, complement regulatory protein Neighboring gene STARR-positive B cell enhancer ABC_E11117 Neighboring gene STARR-seq mESC enhancer starr_03504 Neighboring gene predicted gene, 32313 Neighboring gene complement receptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E11118 Neighboring gene predicted gene, 29726

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The murine complement regulator Crry: new insights into the immunobiology of complement regulation. Molina H. Cell Mol Life Sci, 2002 Feb. PMID 11915940, Free PMC Article
  2. Cutting edge: treatment of complement regulatory protein deficiency by retroviral in vivo gene therapy. Spitzer D, et al. J Immunol, 2006 Oct 15. PMID 17015675
  3. Astrocyte-specific expression of a soluble form of the murine complement control protein Crry confers demyelination protection in the cuprizone model. Briggs DT, et al. Glia, 2007 Nov 1. PMID 17674370
  4. Altered renal tubular expression of the complement inhibitor Crry permits complement activation after ischemia/reperfusion. Thurman JM, et al. J Clin Invest, 2006 Feb. PMID 16444293, Free PMC Article
  5. In vivo correction of complement regulatory protein deficiency with an inhibitor targeting the red blood cell membrane. Spitzer D, et al. J Immunol, 2005 Dec 1. PMID 16301687

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression dynamics of Crry at the implantation sites in normal pregnancy and response against miscarriage induction.
    Title: Expression dynamics of Crry at the implantation sites in normal pregnancy and response against miscarriage induction.
  2. Expression of a Crry/p65 is reduced in acute lung injury induced by extracellular histones.
    Title: Expression of a Crry/p65 is reduced in acute lung injury induced by extracellular histones.
  3. Our study uncovers a damaging effect of complement C3 or downstream complement activation in glaucoma, and it establishes AAV2.CR2-Crry as a viable therapeutic strategy to target pathogenic C3-mediated complement activation in the glaucomatous retina
    Title: Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma.
  4. CRRY role in the retinal epithelium and photoreceptor degeneration
    Title: Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease.
  5. Factor H and Crry are critical for regulating complement activation at distinct anatomic sites within the kidney.
    Title: Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury.
  6. this study has provided direct evidence for a role of Crry in controlling spontaneous alternative pathway complement activation on renal tubular epithelial cells.
    Title: Tissue-specific deletion of Crry from mouse proximal tubular epithelial cells increases susceptibility to renal ischemia-reperfusion injury.
  7. HBx can up-regulate CD59 and Crry expression in podocytes through activating the P38 pathway.
    Title: [Hepatitis B virus X protein upregulates the expression of CD59 and Crry in mouse podocytes].
  8. Crry costimulation enhanced the in vitro expansion of natural Treg cells while maintaining their phenotypic and suppressive properties. Crry-expanded Treg cells decreasing antigen-dependent secretion of cytokines.
    Title: Complement regulatory protein Crry/p65 costimulation expands natural treg cells with enhanced suppressive properties in proteoglycan-induced arthritis.
  9. Stmn2 and the chromosome 14 Rarb region, but not Cr1 or Clu or Picalm, have roles in prion disease.
    Title: The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse.
  10. There is a significant reduction in the numbers of both neutrophils and macrophages in cardiac isografts isolated from mice treated with either complement receptor 2-Crry or CR2-factor H.
    Title: Targeted complement inhibitors protect against posttransplant cardiac ischemia and reperfusion injury and reveal an important role for the alternative pathway of complement activation.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102484

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables complement component C3b binding ISO
Inferred from Sequence Orthology
more info
  
enables complement component C3b receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables complement component C4b binding ISO
Inferred from Sequence Orthology
more info
  
enables complement component C4b receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T cell mediated immunity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to hypoxia IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within complement activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of complement activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of complement activation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of complement activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of complement activation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within regulation of complement activation TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within regulation of complement-dependent cytotoxicity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
complement component receptor 1-like protein
Names
complement component (3b/4b) receptor 1-like
complement receptor related protein
complement regulatory protein Crry
protein p65

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355060.1 → NP_001341989.1  complement component receptor 1-like protein isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC139206, AK134226
    Consensus CDS
    CCDS87948.1
    UniProtKB/Swiss-Prot
    E9QL18, Q3TV30, Q58E68, Q61447, Q61449, Q64735, Q8CF59, Q8K328
    UniProtKB/TrEMBL
    A0A0A6YY75
    Related
    ENSMUSP00000142309.2, ENSMUST00000193094.6
    Conserved Domains (1) summary
    cl27761
    Location:42 → 295
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

  2. NM_001355061.1 → NP_001341990.1  complement component receptor 1-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC139206, AK160440
    Consensus CDS
    CCDS87947.1
    UniProtKB/TrEMBL
    A0A0A6YXN9
    Related
    ENSMUSP00000142069.2, ENSMUST00000194111.6
    Conserved Domains (1) summary
    cl27761
    Location:4 → 257
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

  3. NM_013499.2 → NP_038527.2  complement component receptor 1-like protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_038527.2

    Status: VALIDATED

    Source sequence(s)
    AI098173, AK004825, CA491482
    Consensus CDS
    CCDS15641.1
    UniProtKB/Swiss-Prot
    E9QL18, Q3TV30, Q58E68, Q61447, Q61449, Q64735, Q8CF59, Q8K328
    Related
    ENSMUSP00000074902.7, ENSMUST00000075451.12
    Conserved Domains (4) summary
    cd00033
    Location:165 → 232
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:237 → 293
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:42 → 295
    PHA02927; secreted complement-binding protein; Provisional
    pfam00084
    Location:42 → 98
    Sushi; Sushi repeat (SCR repeat)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    194781019..194813878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64735.1 GenPept UniProtKB/Swiss-Prot:Q64735

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