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LOC129390094 MPRA-validated peak7293 silencer [ Homo sapiens (human) ]

Gene ID: 129390094, updated on 14-Oct-2023

Summary

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Gene symbol
LOC129390094
Gene description
MPRA-validated peak7293 silencer
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was identified as an uncharacterized cis-regulatory element (CRE) that lacked a promoter, enhancer or CTCF-bound insulator chromatin signature. It was validated as a silencer that could repress activity of a super core promoter (SCP1) by STARR-seq massively parallel reporter assays (MPRAs) in K562 erythroleukemia cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129390094 in Genome Data Viewer
Location:
chromosome: 9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (92754393..92754593)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (104920955..104921155)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987095 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28598 Neighboring gene Sharpr-MPRA regulatory region 2132 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_109781 Neighboring gene ribosomal protein L21 pseudogene 86 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_109803 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_109806 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28599 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95486509-95487365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95487366-95488221 Neighboring gene BICD cargo adaptor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95490871-95491710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95497030-95497629 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28601 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95509749-95510500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:95511252-95511934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28603 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20032 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20033 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95560348-95560848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95560849-95561349 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28604 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:95563131-95563631 Neighboring gene uncharacterized LOC101929748 Neighboring gene translation initiation factor IF-2-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:95569982-95570872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20034 Neighboring gene ankyrin repeat domain 19, pseudogene Neighboring gene RNA, U6 small nuclear 714, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Candidate silencer elements for the human and mouse genomes. Doni Jayavelu N, et al. Nat Commun, 2020 Feb 26. PMID 32103011, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_155724.1 

    Range
    101..301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    92754393..92754593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    104920955..104921155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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