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LOC129389453 MPRA-validated peak5682 silencer [ Homo sapiens (human) ]

Gene ID: 129389453, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129389453
Gene description
MPRA-validated peak5682 silencer
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was identified as an uncharacterized cis-regulatory element (CRE) that lacked a promoter, enhancer or CTCF-bound insulator chromatin signature. It was validated as a silencer that could repress activity of a super core promoter (SCP1) by STARR-seq massively parallel reporter assays (MPRAs) in K562 erythroleukemia cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129389453 in Genome Data Viewer
Location:
chromosome: 6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (15583284..15583484)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (15456472..15456672)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (15583515..15583715)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374947 Neighboring gene MPRA-validated peak5680 silencer Neighboring gene dystrobrevin binding protein 1 Neighboring gene Sharpr-MPRA regulatory region 14615 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:15551965-15552513 Neighboring gene DTNBP1 antisense RNA 1 Neighboring gene MPRA-validated peak5681 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24086 Neighboring gene MPRA-validated peak5684 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr6:15641694-15641884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24087 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16953 Neighboring gene MPRA-validated peak5686 silencer Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:15725723-15726536 Neighboring gene uncharacterized LOC102724520 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:15745025-15745698 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:15745699-15746372 Neighboring gene MPRA-validated peak5688 silencer Neighboring gene MPRA-validated peak5689 silencer Neighboring gene uncharacterized LOC105374948

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Candidate silencer elements for the human and mouse genomes. Doni Jayavelu N, et al. Nat Commun, 2020 Feb 26. PMID 32103011, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_155083.1 

    Range
    101..301
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    15583284..15583484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    15456472..15456672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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