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LOC128926657 STARR-seq mESC enhancer starr_29852 [ Mus musculus (house mouse) ]

Gene ID: 128926657, updated on 8-Feb-2024

Summary

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Gene symbol
LOC128926657
Gene description
STARR-seq mESC enhancer starr_29852
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rr369258
Summary
This genomic region includes an enhancer that was validated by the STARR-seq (self-transcribing active regulatory region sequencing) reporter assay in ground-state (2iL) and metastable (SL) mouse embryonic stem cells, where it was defined as a C1 class enhancer that overlaps an active chromatin signature. This locus also includes three candidate cis-regulatory modules (CRMs) that were identified in developing mouse thymocytes based on a combination of DNase I hypersensitivity and transcription factor binding. Those CRMs were validated as active enhancers by high-throughput CapStarr-seq reporter assays, with all three having weak activity in NIH3T3 fibroblasts, and one additionally had strong activity in P5424 T cells while another additionally had weak activity activity in P5424 T cells. This locus additionally includes two B cell regulatory elements that were identified by FAIRE-seq (formaldehyde-assisted isolation of regulatory elements sequencing), and which were validated as enhancers by STARR-seq in lipopolysaccharide-activated mouse splenic B cells. [provided by RefSeq, Oct 2023]
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Genomic context

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See LOC128926657 in Genome Data Viewer
Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69467343..69474076)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ephrin B3 Neighboring gene WD repeat containing, antisense to Trp53 Neighboring gene ribosomal protein S27, pseudogene 2 Neighboring gene transformation related protein 53 Neighboring gene STARR-seq mESC enhancer starr_29854 Neighboring gene ATPase, Na+/K+ transporting, beta 2 polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E10681 Neighboring gene sex hormone binding globulin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High-throughput and quantitative assessment of enhancer activity in mammals by CapStarr-seq. Vanhille L, et al. Nat Commun, 2015 Apr 15. PMID 25872643
  2. Gene regulatory networks STARR-ing B cells. Martínez de Paz A, et al. Nat Immunol, 2020 Feb. PMID 31873293, Free PMC Article
  3. Charting the cis-regulome of activated B cells by coupling structural and functional genomics. Chaudhri VK, et al. Nat Immunol, 2020 Feb. PMID 31873292
  4. STARR-seq identifies active, chromatin-masked, and dormant enhancers in pluripotent mouse embryonic stem cells. Peng T, et al. Genome Biol, 2020 Sep 10. PMID 32912294, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Other Names

  • CapStarr-seq enhancer MGSCv37_chr11:69392789-69392898
  • CapStarr-seq enhancer MGSCv37_chr11:69393731-69393914
  • CapStarr-seq enhancer MGSCv37_chr11:69394623-69394806
  • STARR-positive B cell enhancer ABC_E7005
  • STARR-positive B cell enhancer ABC_E9365
  • regulatory region 369258

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_152303.2 

    Range
    101..6834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69467343..69474076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version