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LOC128924531 CapStarr-seq enhancer MGSCv37_chr2:38499471-38499654 [ Mus musculus (house mouse) ]

Gene ID: 128924531, updated on 8-Feb-2024

Summary

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Gene symbol
LOC128924531
Gene description
CapStarr-seq enhancer MGSCv37_chr2:38499471-38499654
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rr367189
Summary
This locus includes a subregion that was identified as a candidate cis-regulatory module (CRM) in developing mouse thymocytes based on a combination of DNase I hypersensitivity and transcription factor binding. That CRM was validated as an active enhancer by high-throughput CapStarr-seq reporter assays showing weak activity in P5424 T cells and NIH3T3 fibroblasts. This locus also includes a B cell regulatory element that was identified by FAIRE-seq (formaldehyde-assisted isolation of regulatory elements sequencing), and which was validated as an enhancer by STARR-seq (self-transcribing active regulatory region sequencing) in lipopolysaccharide-activated mouse splenic B cells. [provided by RefSeq, Oct 2023]
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Genomic context

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See LOC128924531 in Genome Data Viewer
Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (38533808..38534146)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 6 Neighboring gene predicted gene, 35808 Neighboring gene STARR-seq mESC enhancer starr_04330 Neighboring gene STARR-seq mESC enhancer starr_04333 Neighboring gene STARR-positive B cell enhancer mm9_chr2:38471578-38471879 Neighboring gene proteasome (prosome, macropain) subunit, beta type 7 Neighboring gene STARR-positive B cell enhancer ABC_E4445 Neighboring gene STARR-seq mESC enhancer starr_04335 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene STARR-seq mESC enhancer starr_04336 Neighboring gene adhesion G protein-coupled receptor D2, pseudogene Neighboring gene predicted gene, 36744 Neighboring gene Nr5a1 enhancer region in intron 6 Neighboring gene Nr5a1 enhancer in intron 4 Neighboring gene Nr5a1 5' regulatory region Neighboring gene nuclear receptor subfamily 5, group A, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High-throughput and quantitative assessment of enhancer activity in mammals by CapStarr-seq. Vanhille L, et al. Nat Commun, 2015 Apr 15. PMID 25872643

GeneRIFs: Gene References Into Functions

General gene information

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Other Names

  • STARR-positive B cell enhancer ABC_E4446
  • regulatory region 367189

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_152600.2 

    Range
    101..439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    38533808..38534146
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version