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LOC128897171 KLF11-I enhancer [ Homo sapiens (human) ]

Gene ID: 128897171, updated on 10-Oct-2023

Summary

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Gene symbol
LOC128897171
Gene description
KLF11-I enhancer
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was identified as a DNase I hypersensitive site (DHS) in erythroid cells. It was validated as an enhancer that can activate the KLF11 (KLF transcription factor 11) promoter by reporter assays in K562 erythroleukemia cells and HeLa cervical carcinoma cells. [provided by RefSeq, Mar 2023]
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Genomic context

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Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (10029107..10029431)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (10057856..10058180)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10080877-10081377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11145 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11146 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11147 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11148 Neighboring gene grainyhead like transcription factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11149 Neighboring gene uncharacterized LOC124905970 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:10151718-10152656 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:10152657-10153594 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:10155429-10156119 Neighboring gene uncharacterized LOC112268412 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:10170473-10170643 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10173619-10174119 Neighboring gene KLF11 promoter region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11151 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11153 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10185594-10186333 Neighboring gene KLF11 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10188595-10189095 Neighboring gene KLF transcription factor 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comprehensive characterization of erythroid-specific enhancers in the genomic regions of human Krüppel-like factors. Xiong Q, et al. BMC Genomics, 2013 Aug 28. PMID 23985037, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_149963.1 

    Range
    101..425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    10029107..10029431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    10057856..10058180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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